HNRNPAB - heterogeneous nuclear ribonucleoprotein A/B Gene

中文名称：异质核核糖核蛋白 A/B

种属: Homo sapiens

同用名: ABBP1; HNRPAB

关于 HNRNPAB

功能概要

该基因属于普遍表达的异质核核糖核蛋白 (hnRNP) 亚家族。 hnRNPs 由 RNA 聚合酶 II 产生，是异质核 RNA (hnRNA) 复合物的组成部分。它们与细胞核中的前体 mRNA 相关，并且似乎影响前体 mRNA 加工以及 mRNA 代谢和运输的其他方面。虽然所有的 hnRNP 都存在于细胞核中，但有些似乎在细胞核和细胞质之间穿梭。 hnRNP 蛋白具有独特的核酸结合特性。由该基因编码的蛋白质与多蛋白编辑体复合物的一种成分结合，具有两个重复的与 RNA 结合的准 RRM (RNA 识别基序) 结构域。已针对该基因描述了编码不同同种型的两种可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]