PRMT2 - protein arginine methyltransferase 2 Gene

中文名称：蛋白质精氨酸甲基转移酶 2

种属: Homo sapiens

同用名: HRMT1L1

基因 ID: 3275 | 基因类型: protein coding

关于 PRMT2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:46,635,674-46,665,124 (from NCBI)

This gene has 15 transcripts (splice variants), 159 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 11.6), spleen (RPKM 8.9) and 25 other tissues.

功能概要

启用多种功能，包括核受体结合活性；过氧化物酶体增殖物激活受体结合活性；和蛋白质同二聚化活性。参与多个过程，包括组蛋白甲基化；调节雄激素受体信号通路；和转录调控，DNA 模板化。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein homodimerization activity. Involved in several processes, including histone methylation; regulation of Androgen Receptor signaling pathway; and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PRMT2 基因产物(8)

mRNA	Protein	Name
NM_001242864.3	NP_001229793.1	protein arginine N-methyltransferase 2 isoform 2
NM_001242865.3	NP_001229794.1	protein arginine N-methyltransferase 2 isoform 3
NM_001242866.3	NP_001229795.1	protein arginine N-methyltransferase 2 isoform 4
NM_001286676.2	NP_001273605.1	protein arginine N-methyltransferase 2 isoform 5
NM_001286677.2	NP_001273606.1	protein arginine N-methyltransferase 2 isoform 6
NM_001286678.2	NP_001273607.1	protein arginine N-methyltransferase 2 isoform 7
NM_001535.5	NP_001526.2	protein arginine N-methyltransferase 2 isoform 1
NM_206962.4	NP_996845.1	protein arginine N-methyltransferase 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables histone methyltransferase activity	IDA IDA: 通过直接分析推断	19405910	GOA
enables nuclear androgen receptor binding	IPI IPI: 通过物理相互作用推断	17587566	GOA
enables nuclear estrogen receptor binding	IDA IDA: 通过直接分析推断	17587566	GOA
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	12039952	GOA
enables nuclear progesterone receptor binding	IPI IPI: 通过物理相互作用推断	12039952	GOA
enables nuclear retinoic acid receptor binding	IPI IPI: 通过物理相互作用推断	12039952	GOA
enables nuclear thyroid hormone receptor binding	IPI IPI: 通过物理相互作用推断	12039952	GOA
enables peroxisome proliferator activated receptor binding	IPI IPI: 通过物理相互作用推断	12039952	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11513728	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	12039952	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	12039952	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	16648481	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	16648481	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12039952	GOA
involved in positive regulation of apoptotic process	IGI IGI: 通过遗传相互作用推断	16648481	GOA
involved in regulation of androgen receptor signaling pathway	IDA IDA: 通过直接分析推断	17587566	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11513728	GOA
located in cytosol	IDA IDA: 通过直接分析推断	17587566	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11513728	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRMT2 蛋白结构

SH3_9

PRMT5

0
100
200
300
400
433 a.a.

蛋白主名

其他名称

protein arginine N-methyltransferase 2

HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1

PRMT2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRMT2	P55345	SHANK3	Homo sapiens	Q9BYB0	Y2H Pooling	21653829
种属内	PRMT2	P55345	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	33961781
种属内	PRMT2	P55345	SHANK3	Homo sapiens	Q9BYB0	Anti Tag CoIP	28514442
种属内	PRMT2	P55345	RBM12	Homo sapiens	Q9NTZ6	Validated Y2H	26871637
种属内	PRMT2	P55345	RBM12	Homo sapiens	Q9NTZ6	Y2H Prey Pooling	26871637
种属内	PRMT2	P55345	RBM12	Homo sapiens	Q9NTZ6	Y2H Array	26871637
种属内	PRMT2	P55345	HTT	Homo sapiens	P42858	Anti Tag CoIP	28514442
种属内	PRMT2	P55345	HTT	Homo sapiens	P42858	Y2H	17500595
种属内	PRMT2	P55345	HTT	Homo sapiens	P42858	Anti Tag CoIP	33961781
种属内	PRMT2	P55345	RB1	Homo sapiens	P06400	Anti Bait CoIP	16616919
种属内	PRMT2	P55345	CBLB	Homo sapiens	Q13191	Y2H Prey Pooling	26871637
种属内	PRMT2	P55345	CBLB	Homo sapiens	Q13191	Validated Y2H	26871637
种属内	PRMT2	P55345	CBLB	Homo sapiens	Q13191	Y2H Array	26871637
种属内	PRMT2	P55345	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11170	PRMT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRMT2	MGD	MGI:1316652
Bos taurus	PRMT2	VGNC	VGNC:33348
Felis catus	PRMT2	VGNC	VGNC:67651
Rattus norvegicus	PRMT2	RGD	RGD:1565519
Canis familiaris	PRMT2	VGNC	VGNC:44996
Macaca mulatta	PRMT2	VGNC	VGNC:76359
Others	PRMT2	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRMT2 - protein arginine methyltransferase 2 Gene

关于 PRMT2

功能概要

PRMT2 基因产物(8)

PRMT2 蛋白结构

PRMT2 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PRMT2 - protein arginine methyltransferase 2 Gene

关于 PRMT2

功能概要

PRMT2 基因产物(8)

PRMT2 蛋白结构

PRMT2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z