TRIM69 - tripartite motif containing 69 Gene

中文名称：含三方基序 69

种属: Homo sapiens

同用名: Trif; HSD34; RNF36; HSD-34

关于 TRIM69

功能概要

该基因编码 RING-B-box-coiled-coil (RBCC) 家族的成员，并编码具有 N-末端 RING 指基序、PRY 结构域和 C-末端 SPRY 结构域的蛋白质。该基因的小鼠直系同源物在精子发生过程中的圆形精子细胞阶段在生殖细胞中特异性表达，当过度表达时，会诱导细胞凋亡。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces Apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]