1. Gene
  2. KRT17 - keratin 17 Gene

KRT17 - keratin 17 Gene

中文名称:角蛋白 17

种属: Homo sapiens

同用名: PC; K17; PC2; 39.1; CK-17; PCHC1

基因 ID: 3872 | 基因类型: protein coding

关于 KRT17

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,619,442-41,624,575 (from NCBI)

This gene has 8 transcripts (splice variants), 80 orthologues, 68 paralogues and is associated with 6 phenotypes. Biased expression in urinary bladder (RPKM 147.9), skin (RPKM 53.6) and 3 other tissues.

功能概要

该基因编码 I 型中间丝链角蛋白 17,在甲床、毛囊、皮脂腺和其他表皮附属物中表达。该基因的突变导致 Jackson-Lawler 型先天性厚甲症和多发性脂肪囊肿。[RefSeq 提供,2008 年 8 月]

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

KRT17 基因产物(1)

mRNA Protein Name
NM_000422.3 NP_000413.1 keratin, type I cytoskeletal 17
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KRT17 蛋白结构

Filament

Filament: Intermediate filament protein (84 - 393)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
蛋白主名 其他名称

keratin, type I cytoskeletal 17

cytokeratin-17

KRT17 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KRT17 Q04695 EEF1G Homo sapiens P26641
Anti Bait CoIP
17906640
Intra KRT17 Q04695 CCDC85B Homo sapiens Q15834
Y2H Pooling
16189514
Intra KRT17 Q04695 CCDC85B Homo sapiens Q15834
Pull Down
16189514
Intra KRT17 Q04695 TRIM69 Homo sapiens Q86WT6
Y2H Array
25416956
Intra KRT17 Q04695 TRIM69 Homo sapiens Q86WT6
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Steatocystoma Multiplex

Sebocystomatosis

Multiple Sebaceous Cysts

Multiplex Steatocystoma

Sebaceous Cysts, Multiple

SM

Pachyonychia Congenita 2

Pachyonychia Congenita, Type 2

PC2

Pachyonychia Congenita, Jackson-Lawler Type, Formerly

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2

Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita

Anonychia

Hyponychia Congenita

NDNC4

Anonychia/Hyponychia Congenita

Nonsyndromic Congenital Nail Disorder 4

Isolated Congenital Anonychia

Anonychia Congenita Totalis

Anonychia Totalis

Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4

Congenital Anonychia

Nonsyndromic Congenital Nail Disorder, 4

Absent Nails

Aplastic Nails

Congenital Absence Of Nails

Isolated Anonychia

Nail Disorder, Non-Syndromic Congenital, 4

Nail Disorder, Nonsyndromic, Congenital, Type 4

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Pili Torti, Early-Onset

Pili Torti

Twisted Hair

Pili Torti, Ronchese Type

Coarse, Dry, Lusterless Hair Which Breaks Off Easily

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa

Cervical Intraepithelial Neoplasia

CIN

Palmoplantar Keratoderma, Nonepidermolytic

Nonepidermolytic Palmoplantar Keratoderma

NEPPK

Tylosis

Unna-Thost Syndrome

Keratoderma, Palmoplantar, Diffuse

Ppkne

Keratoderma, Nonepidermolytic Palmoplantar

Diffuse Nonepidermolytic Palmomplantar Keratoderma

Thost-Unna Syndrome

Non-Epidermolytic Palmoplantar Keratoderma

Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type

Diffuse Palmoplantar Keratoderma, Bothnian Type

Krt1-Related Diffuse Nonepidermolytic Keratoderma

Krt1-Related Diffuse Neppk

Keratoderma, Palmoplantar, Non-Epidermolytic

Nonepidermolytic Unna-Thost Disease

Non-Epidermolytic Unna-Thost Disease

Keratoderma, Palmoplantar, Nonepidermolytic

Hyperkeratosis

Psoriasis
Cervical Adenoid Basal Carcinoma
Clear Cell Basal Cell Carcinoma

Skin Clear Cell Basal Cell Carcinoma

Epidermoid Cysts

Epidermoid Cyst

Sebaceous Cyst

Epidermal Inclusion Cyst

Epidermal Cyst

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma

Bullous Ichthyosiform Erythroderma

EHK

Bullous Erythroderma Ichthyosiformis Congenita Of Brocq

Bcie

Bie

Epidermolytic Ichthyosis

Ichthyosis Bullosa Of Siemens

Superficial Epidermolytic Ichthyosis

Hyperkeratosis, Epidermolytic

Congenital Bullous Ichthyosiform Erythroderma

Bullous Type Ichthyosis

Epidermolytic Palmoplantar Hyperkeratosis

Bullous Ichthyosiform Erythroderma Congenita

Bullous Erythroderma Ichthyosiforme

Sei

Epidermolytic Hyperkeratosis Late-Onset

Epidermolytic Hyperkeratosis, Late-Onset

Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis

Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal

Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

Monilethrix

Beaded Hair

MNLIX

Nodose Hair

Moniliform Hair Syndrome

Acrokeratosis Verruciformis

Acrokeratosis Verruciformis Of Hopf

Hopf Disease

AKV

Akv Of Hopf

Inverted Follicular Keratosis

Inverted Folicular Keratosis

Seborrheic Keratosis

Palmoplantar Keratosis

Palmoplantar Keratoderma

Keratosis Palmaris Et Plantaris

Palmo-Plantar Keratodermas

Keratoderma, Palmoplantar

Keratoderma Palmoplantar

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis Of Palms And Soles

Palmoplantar Hyperkeratosis

Follicular Infundibulum Tumor

Tumor Of Follicular Infundibulum

Follicular Infundibulum Tumour

Neoplasm Of The Follicular Infundibulum

Tumour Of Follicular Infundibulum

Large Cell Acanthoma
Focal Palmoplantar Keratoderma

Focal Ppk

Focal Keratosis Palmoplantaris

Focal Palmoplantar Hyperkeratosis

Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Epidermolysis Bullosa

Acantholysis Bullosa

Eb

Eccrine Papillary Adenoma

Papillary Eccrine Adenoma

Eccrine Papillary Adenoma Of Skin

Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Gall Duct

Ca Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Biliary Passages

Intrahepatic Bile Duct Carcinoma

Extrahepatic Bile Duct Adenocarcinoma

Adenocarcinoma Of The Extrahepatic Bile Duct

Adenocarcinoma Of Extrahepatic Bile Duct

Morpheaform Basal Cell Carcinoma

Basal Cell Carcinoma, Morphea

Cicatricial Basal-Cell Carcinoma

Morphea-Type Basal Cell Carcinoma

Morpheic Basal Cell Carcinoma

Keratosis

Actinic Keratosis

Hyperkeratosis

Ampulla Of Vater Cancer

Ampulla Of Vater Carcinoma

Ampullary Carcinoma

Malignant Tumour Of Ampulla Of Vater

Carcinoma Of Ampulla Of Vater

Carcinoma Of The Ampulla Of Vater

Ampulloma

Glossitis

Inflammation Of Tongue

Tongue Inflammation

Glazed Tongue

Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD

Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma

Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering

Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse

Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Uterus Carcinoma In Situ
Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix

Carcinoma In Situ Of Uterine Cervix

Cervical Intraepithelial Neoplasia

Carcinoma Of Cervix Stage 0

Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

Cervix Ca In Situ

Cin Iii

Cin Iii - Carcinoma In Situ Of Cervix

Cin Iii - Severe Dyskaryosis

Severe Dysplasia Of Cervix

Severe Dysplasia Of The Cervix Uteri

Squamous Intraepithelial Neoplasia, Grade Iii

Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Polycystic Liver Disease 1 With Or Without Kidney Cysts

Polycystic Liver Disease 1

PCLD1

Cyst

Liver Disease, Polycystic, Type 1

Polycystic Liver Disease

Infiltrative Basal Cell Carcinoma

Skin Infiltrating Basal Cell Carcinoma

Basaloid Squamous Cell Carcinoma

Basaloid Carcinoma

Malignant Syringoma

Microcystic Adnexal Carcinoma

Microcystic Adnexal Carcinoma Of Skin

Syringomatous Carcinoma

Eccrine Epithelioma

Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder

Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour

Corneal Dystrophy
Cribriform Carcinoma

Ductal Carcinoma, Cribriform Type

Carcinoma Cribriform

Carcinoma, Cribriform

Synchronous Bilateral Breast Carcinoma
Sebaceous Gland Disease

Sebaceous Gland Anomaly

Sebaceous Gland Diseases

Borst-Jadassohn Intraepidermal Carcinoma

Intraepidermal Epithelioma Of Jadassohn

Bowen'S Disease, Clonal

Keratosis, Seborrheic

Seborrheic Keratosis

Keratosis, Seborrheic, Somatic

Basal Cell Papilloma

Keratosis Seborrheica

KERSEB

Pilomatrixoma

Pilomatricoma

PTR

Epithelioma Calcificans Of Malherbe

Benign Pilomatricoma

Calcifying Epithelioma Of Malherbe

Pilomatricoma, Somatic

Benign Pilomatrixoma

Malherbe Calcifying Epithelioma

Epidermolysis Bullosa Simplex Localized Type

Epidermolysis Bullosa Simplex, Weber-Cockayne Type

Weber-Cockayne Syndrome

Ebs-Loc

Epidermolysis Bullosa Simplex Of Palms And Soles

Epidermolysis Bullosa Simplex Weber-Cockayne Type

Epidermolysis Bullosa Simplex, Localized

Epidermolysis Bullosa Of Hands And Feet

Weber-Cockayne Type Epidermolysis Bullosa Simplex

Localized Epidermolysis Bullosa Simplex

Localized Ebs

Pre-Malignant Neoplasm
In Situ Carcinoma

Carcinoma In Situ

Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus KRT17 VGNC VGNC:108193
Rattus norvegicus KRT17 RGD RGD:1303181
Canis familiaris KRT17 VGNC VGNC:55622
Mus musculus KRT17 MGD MGI:96691
Bos taurus KRT17 VGNC VGNC:50398