2. Gene
  3. ASNS - asparagine synthetase (glutamine-hydrolyzing) Gene

ASNS - asparagine synthetase (glutamine-hydrolyzing) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：天冬酰胺合成酶 (谷氨酰胺水解)

种属: Homo sapiens

同用名: TS11; ASNSD

基因 ID: 440 | 基因类型: protein coding

关于 ASNS

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:97,851,677-97,928,441 (from NCBI)

This gene has 17 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 19.6), testis (RPKM 14.4) and 24 other tissues.

功能概要

该基因编码的蛋白质参与天冬酰胺的合成。该基因补充了温度敏感的仓鼠突变体 ts11 中的突变，后者在非允许温度下阻止细胞周期的 G1 期进展。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

ASNS 基因产物(7)

mRNA Protein Name
NM_001178075.2 NP_001171546.1 asparagine synthetase [glutamine-hydrolyzing] isoform b
NM_001178076.2 NP_001171547.1 asparagine synthetase [glutamine-hydrolyzing] isoform c
NM_001178077.1 NP_001171548.1 asparagine synthetase [glutamine-hydrolyzing] isoform c
NM_001352496.2 NP_001339425.1 asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_001673.5 NP_001664.3 asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_133436.3 NP_597680.2 asparagine synthetase [glutamine-hydrolyzing] isoform a
NM_183356.4 NP_899199.2 asparagine synthetase [glutamine-hydrolyzing] isoform a

ASNS 蛋白结构

GATase_7

GATase_7: Glutamine amidotransferase domain (49 - 164)

Asn_synthase

Asn_synthase: Asparagine synthase (235 - 467)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 561 a.a.
蛋白主名 其他名称

asparagine synthetase [glutamine-hydrolyzing]

TS11 cell cycle control protein

ASNS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ASNS P08243 TRIM69 Homo sapiens Q86WT6-2
Validated Y2H
32296183
Intra ASNS P08243 TRIM69 Homo sapiens Q86WT6-2
Y2H Array
32296183
Intra ASNS P08243 TRIM69 Homo sapiens Q86WT6-2
Y2H Prey Pooling
32296183
Intra ASNS P08243 TRIM69 Homo sapiens Q86WT6
Y2H Prey Pooling
25416956
Intra ASNS P08243 TRIM69 Homo sapiens Q86WT6
Y2H Array
25416956
Intra ASNS P08243 WDR27 Homo sapiens A2RRH5
Validated Y2H
25416956
Intra ASNS P08243 WDR27 Homo sapiens A2RRH5
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Asparagine Synthetase Deficiency

Asns Deficiency

ASNSD

Congenital Microcephaly-Severe Encephalopathy-Progressive Cerebral Atrophy Syndrome

Disorder Of Asparagine Metabolism

Congenital Microcephaly - Severe Encephalopathy - Progressive Cerebral Atrophy Syndrome
Neuronal Migration Disorders

Abnormality Of Neuronal Migration

Malformations Of Cortical Development, Group Ii

Neuronal Dysmigration Syndromes
Childhood Acute Lymphocytic Leukemia

Childhood Acute Lymphoblastic Leukemia

Childhood All

Pediatric Acute Lymphoblastic Leukemia

Lymphoblastic Leukemia Acute Childhood
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia
Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma

Adult Hepatoma

Adult Hcc
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

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生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14874 Topiroxostat Inhibitor 99.63% 否
HY-123319 Antofloxacin hydrochloride Inhibitor / 否
HY-123319A Antofloxacin Inhibitor / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-P0069 D-JNKI-1 Inhibitor 98.47% Phase 3
HY-103018 Gusacitinib Inhibitor 99.41% Phase 2
HY-103018A Gusacitinib hydrochloride Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (72)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128946 CL2A-SN-38 99.07% 否
HY-136579 ASN007 Inhibitor 99.70% 否
HY-128923 SKF-34288 hydrochloride Inhibitor 96.35% 否
HY-136626 Z-Ala-Ala-Asn-AMC 99.47% 否
HY-112205A RR-11a analog Inhibitor 99.12% 否
HY-108625 SHA 68 Antagonist 99.84% 否
HY-139147 iHCK-37 Inhibitor 99.52% 否
HY-114174 Fmoc-Ala-Glu-Asn-Lys-NH2 99.62% 否
HY-156586 ASN90 Inhibitor 99.63% 否
HY-W002327 Fmoc-Asn(Trt)-OH 99.96% 否
HY-P1043A NGR peptide Trifluoroacetate 98.06% 否
HY-P4385 (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Antagonist 98.56% 否
HY-136579A ASN007 benzenesulfonate Inhibitor 98.06% 否
HY-111323 ASN06917370 99.23% 否
HY-128111 ASN02563583 99.21% 否
HY-150242A Cbz-Ala-Ala-Asn TFA 99.54% 否
HY-N9446 H-Asn(glcnac-beta-D)-OH 98.65% 否
HY-113667 ASN04885796 99.61% 否
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% 否
HY-W010378 D-Asparagine ≥98.0% 否
HY-125028 Hck-IN-1 Inhibitor 98.53% 否
HY-128128 ASN04421891 Modulator 99.00% 否
HY-141464 Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH 95.03% 否
HY-162238 OSM-S-106 Inhibitor 99.34% 否
HY-B1803A Tracazolate hydrochloride Modulator 99.03% 否
HY-E70068 Endo-β-N-acetylglucosaminidase (Endo S) / 否
HY-W009085 Fmoc-Asn-OH 99.17% 否
HY-129360A Ala-Ala-Asn-PAB TFA / 否
HY-P3882 Fmoc-Ala-Glu-Gln-Lys-NH2 99.90% 否
HY-W008233 Z-Asn-OH 98.30% 否
HY-150787 BMS-986339 / 否
HY-113761 ASN03576800 Inhibitor 99.61% 否
HY-122179 NUCC-555 Antagonist / 否
HY-128947 CL2 Linker / 否
HY-129360 Ala-Ala-Asn-PAB / 否
HY-129361 Fmoc-Ala-Ala-Asn-PABC-PNP / 否
HY-130933 Fmoc-Ala-Ala-Asn(Trt)-OH 99.80% 否
HY-131092 H-Asn-Arg-OH / 否
HY-136733 Ac-DNLD-CHO Inhibitor / 否
HY-139245 MC-Ala-Ala-Asn-PAB / 否
HY-141149 Fmoc-PEG4-Ala-Ala-Asn-PAB / 否
HY-141150 Azido-PEG5-Ala-Ala-Asn-PAB / 否
HY-141151 Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB / 否
HY-144628 Fmoc-Asn-Pro-Val-PABC-PNP / 否
HY-144629 Asn-Pro-Val-PABC-MMAE TFA / 否
HY-144630 diSPhMC-Asn-Pro-Val-PABC-MMAE / 否
HY-148031 MC-Ala-Ala-Asn-PAB-PNP / 否
HY-148392 Neu5Gcα(2-6) N-Glycan-Asn / 否
HY-148393 G0 N-glycan-Asn / 否
HY-149360 P-gb-IN-1 Inhibitor / 否
HY-151146 (1R,3S)-THCCA-Asn Inhibitor / 否
HY-156314 ASN 07115873 / 否
HY-164457 ASN-001 Inhibitor / 否
HY-P1962 β-Secretase inhibitor Inhibitor / 否
HY-P2212 Angiotensin amide / 否
HY-P2397 Fmoc-Asn(Trt)-Thr(psi(Me,Me)pro)-OH / 否
HY-P2401 Fmoc-Asn(Trt)-Ser(psi(Me,Me)pro)-OH / 否
HY-P3615 [Asn18] Endothelin-1, human Agonist / 否
HY-P4019 Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 / 否
HY-P4893 (Gln22,Asn23)-Amyloid β-Protein (1-40) / 否
HY-P4919 Mca-SEVNLDAEFK(Dnp) / 否
HY-P5331 [Asn23]-beta-Amyloid (1-42), iowa mutation / 否
HY-P5365 [Asn23] β-Amyloid (1-40), Iowa mutation / 否
HY-RS01098 ASNS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W002327S Fmoc-Asn(Trt)-OH-13C4,15N2 / 否
HY-W091365 Boc-Asn(Xan)-OH / 否
HY-118731 TNK-6123 Activator / 否
HY-141152 Azido-PEG4-Ala-Ala-Asn(Trt)-PAB / 否
HY-141153 Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP / 否
HY-151829 Fmoc-L-Asn(EDA-N3)-OH / 否
HY-157338 NHS-Ala-Ala-Asn-active metabolite Inhibitor / 否
HY-P1043 NGR peptide / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ASNS RGD RGD:2162
Mus musculus ASNS MGD MGI:1350929
Macaca mulatta ASNS VGNC VGNC:80798
Felis catus ASNS VGNC VGNC:69354
Canis familiaris ASNS VGNC VGNC:53542
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