2. TGF-beta/Smad
  3. TGF-β Receptor
  4. NUCC-555

NUCC-555 是一种 Activin 拮抗剂。NUCC-555 与 Activin A 结合口袋中的 Trp25、Trp28、Phe55、Tyr93、Lys103 和 Asn107 相互作用。NUCC-555 可阻断 Activin A 介导的肝星状细胞 (HSC) 激活。NUCC-555 可促进肝脏再生并阻止慢性肝病模型中的纤维化进展。NUCC-555 可抑制 Activin A 介导的卵巢细胞增殖。NUCC-555 可降低卵巢切除小鼠的促卵泡激素 (FSH) 水平。

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NUCC-555 Chemical Structure

NUCC-555 Chemical Structure

CAS No. : 1060469-90-0

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规格 是否有货
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NUCC-555 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice[1][2].

分子量

443.50

Formula

C25H25N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NUCC-555 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NUCC-5551060469-90-0NUCC555NUCC 555TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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目录号：
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