2. Metabolic Enzyme/Protease
  3. Thrombin
  4. (1R,3S)-THCCA-Asn

(1R,3S)-THCCA-Asn (4j) 是一种选择性凝血酶 (thrombin) 抑制剂，其 IC50 值在0.07~0.14 μM 的范围内。(1R,3S)-THCCA-Asn 具有抗血栓形成活性。

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(1R,3S)-THCCA-Asn Chemical Structure

(1R,3S)-THCCA-Asn Chemical Structure

CAS No. : 1349084-71-4

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(1R,3S)-THCCA-Asn 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity[1].

体外研究
(In Vitro)

(1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC50 value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%[1].
(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(1R,3S)-THCCA-Asn 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Liver cell (L02), colon mucosa cell (NCM460) and human dermal fibroblasts cell (NHDF)
Concentration: 0.001-1000 μM
Incubation Time: 48 hours
Result: Showed that the IC50 values for cell viability were all higher than 125 μM.
体内研究
(In Vivo)

(1R,3S)-THCCA-Asn (4j) (p.o., 0.001-1 nM/kg) can act against thrombosis of rats in a dose-dependent manner with no toxic side effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD (Sprague Dawley) rats weighing 250-300 g[1]
Dosage: 0.001, 0.01, 1 nM/kg
Administration: p.o.
Result: Resulted in a reduction in thrombus weight of 19.19 mg at the dose of 1 nM/kg compared to the untreated thrombus weight of about 30 mg.
分子量

464.47

Formula

C24H24N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(1R,3S)-THCCA-Asn 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(1R,3S)-THCCA-Asn1349084-71-4Thrombinthrombinanti-platelet aggregationanti-thrombotic activityInhibitorinhibitorinhibit

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