ABL2 - ABL proto-oncogene 2, non-receptor tyrosine kinase Gene

中文名称：ABL 原癌基因 2，非受体酪氨酸激酶

种属: Homo sapiens

同用名: ARG; ABLL

关于 ABL2

功能概要

该基因编码非受体酪氨酸蛋白激酶 Abelson 家族的成员。该蛋白与 c-abl 致癌基因 1 蛋白高度相似，包括酪氨酸激酶、SH2 和 SH3 结构域，它通过其 C 末端肌动蛋白和微管结合序列在细胞骨架重排中发挥作用。该基因在正常细胞和肿瘤细胞中均有表达，并与白血病中的 ets 变体 6 基因易位有关。已为该基因发现了编码不同蛋白质同种型的多个可变剪接转录物变体。[RefSeq 提供，2009 年 11 月]

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]