MMS19 - MMS19 homolog, cytosolic iron-sulfur assembly component Gene

中文名称：MMS19 同系物，胞质铁硫组装成分

种属: Homo sapiens

同用名: CIAO4; MET18; MMS19L; hMMS19

基因 ID: 64210 | 基因类型: protein coding

关于 MMS19

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,458,324-97,498,794 (from NCBI)

This gene has 19 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 18.2), skin (RPKM 14.7) and 25 other tissues.

功能概要

启用雌激素受体结合活性和转录共激活因子活性。涉及多个过程，包括铁硫簇组装；含核碱基复合代谢过程的正向调控；和通过铁硫簇转移的蛋白质成熟。位于胞质溶胶中；核质；和主轴。 CIA 复合体和 MMXD 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables Estrogen Receptor binding activity and transcription coactivator activity. Involved in several processes, including iron-sulfur cluster assembly; positive regulation of nucleobase-containing compound metabolic process; and protein maturation by iron-sulfur cluster transfer. Located in cytosol; nucleoplasm; and spindle. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]

MMS19 基因产物(9)

mRNA	Protein	Name
NM_001289403.2	NP_001276332.1	MMS19 nucleotide excision repair protein homolog isoform 2
NM_001289404.2	NP_001276333.1	MMS19 nucleotide excision repair protein homolog isoform 3
NM_001289405.2	NP_001276334.1	MMS19 nucleotide excision repair protein homolog isoform 1
NM_001330128.2	NP_001317057.1	MMS19 nucleotide excision repair protein homolog isoform 5
NM_001351356.2	NP_001338285.1	MMS19 nucleotide excision repair protein homolog isoform 6
NM_001351357.2	NP_001338286.1	MMS19 nucleotide excision repair protein homolog isoform 7
NM_001351358.2	NP_001338287.1	MMS19 nucleotide excision repair protein homolog isoform 8
NM_001351359.2	NP_001338288.1	MMS19 nucleotide excision repair protein homolog isoform 8
NM_022362.5	NP_071757.4	MMS19 nucleotide excision repair protein homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	11279242	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11279242	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	11279242	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein maturation by iron-sulfur cluster transfer	IDA IDA: 通过直接分析推断	29225034	GOA
involved in protein maturation by iron-sulfur cluster transfer	IMP IMP: 通过突变表型推断	22678361	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MMXD complex	IDA IDA: 通过直接分析推断	20797633	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	20797633	GOA
part of cytosolic [4Fe-4S] assembly targeting complex	IDA IDA: 通过直接分析推断	22678361	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20797633	GOA
located in spindle	IDA IDA: 通过直接分析推断	20797633	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MMS19 蛋白结构

MMS19_N

MMS19_C

0
200
400
600
800
1030 a.a.

蛋白主名

其他名称

MMS19 nucleotide excision repair protein homolog

MET18 homolog

MMS19 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MMS19	Q96T76	CIAO3	Homo sapiens	Q9H6Q4	Anti Tag CoIP	23585563
Intra	MMS19	Q96T76	RTEL1	Homo sapiens	Q9NZ71	Anti Tag CoIP	28178521
Intra	MMS19	Q96T76	BRIP1	Homo sapiens	Q9BX63	Anti Tag CoIP	23585563
Intra	MMS19	Q96T76	ERCC2	Homo sapiens	P18074	Anti Tag CoIP	23585563
Intra	MMS19	Q96T76	ERCC2	Homo sapiens	P18074	Anti Tag CoIP	28178521
Intra	MMS19	Q96T76	CIAO1	Homo sapiens	O76071	Anti Tag CoIP	28514442
Intra	MMS19	Q96T76	CIAO1	Homo sapiens	O76071	Anti Tag CoIP	33961781
Intra	MMS19	Q96T76	CIAO1	Homo sapiens	O76071	Anti Tag CoIP	28178521
Intra	MMS19	Q96T76	CIAO1	Homo sapiens	O76071	Y2H	21516116
Intra	MMS19	Q96T76	CIAO1	Homo sapiens	O76071	Anti Tag CoIP	23585563
Intra	MMS19	Q96T76	CIAO2B	Homo sapiens	Q9Y3D0	Anti Tag CoIP	33961781
Intra	MMS19	Q96T76	CIAO2B	Homo sapiens	Q9Y3D0	Anti Tag CoIP	28178521
Intra	MMS19	Q96T76	CIAO2B	Homo sapiens	Q9Y3D0	Anti Tag CoIP	23585563
Intra	MMS19	Q96T76	CIAO2B	Homo sapiens	Q9Y3D0	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6

Mitochondrial Dna Deletion Syndrome With Progressive Myopathy	PEOA6
Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 6	Dna2-Related Mitochondrial Dna Deletion Syndrome
Mitochondrial Dna Deletion Syndrome With Limb-Girdle Weakness	Mtdna Deletion Syndrome With Limb-Girdle Weakness
Mtdna Deletion Syndrome With Progressive Myopathy	Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 6
Progressive External Ophthalmoplegia, Autosomal Dominant 6	Autosomal Dominant Progressive External Ophthalmoplegia 6
Progressive External Ophthalmoplegia Autosomal Dominant 6	Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 6

Xeroderma Pigmentosum, Complementation Group D

Xeroderma Pigmentosum, Group D	Xpdc
Xeroderma Pigmentosum Iv	XPD
Xeroderma Pigmentosum Group D	Xeroderma Pigmentosum Viii
Xp Group D	Xp Group H
Xp4	Xp8
Xph	Xp, Group D
Xp4 Xeroderma Pigmentosum Viii, Formerly	Xp8, Formerly
Xp, Group H, Formerly	Xph, Formerly
Xeroderma Pigmentosum Complementation Group D	XP-D
Xp-D/Cs

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08562	MMS19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MMS19	MGD	MGI:1919449
Rattus norvegicus	MMS19	RGD	RGD:727890
Canis familiaris	MMS19	VGNC	VGNC:43293
Bos taurus	MMS19	VGNC	VGNC:31534
Felis catus	MMS19	VGNC	VGNC:63541

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MMS19 - MMS19 homolog, cytosolic iron-sulfur assembly component Gene

关于 MMS19

功能概要

MMS19 基因产物(9)

MMS19 蛋白结构

MMS19 蛋白互作信息

关联疾病

直系同源

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MMS19 - MMS19 homolog, cytosolic iron-sulfur assembly component Gene

关于 MMS19

功能概要

MMS19 基因产物(9)

MMS19 蛋白结构

MMS19 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

X

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