2. Gene
  3. LETMD1 - LETM1 domain containing 1 Gene

LETMD1 - LETM1 domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 LETM1 域 1

种属: Homo sapiens

同用名: HCCR; HCCR1; HCCR2; HCCR-1; HCCR-2; HCRR-2; SLC55A3; 1110019O13Rik

基因 ID: 25875 | 基因类型: protein coding

关于 LETMD1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:51,048,220-51,068,958 (from NCBI)

This gene has 38 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 15.5), fat (RPKM 12.3) and 25 other tissues.

功能概要

该基因编码线粒体外膜蛋白。它在肿瘤发生中具有潜在作用，这可能是由 p53 肿瘤抑制基因的负调节引起的。已经注意到该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]

LETMD1 基因产物(25)

mRNA Protein Name
NM_001243689.2 NP_001230618.1 LETM1 domain-containing protein 1 isoform b
NM_001300765.2 NP_001287694.1 LETM1 domain-containing protein 1 isoform c
NM_001351312.2 NP_001338241.1 LETM1 domain-containing protein 1 isoform d
NM_001351313.2 NP_001338242.1 LETM1 domain-containing protein 1 isoform e
NM_001351315.2 NP_001338244.1 LETM1 domain-containing protein 1 isoform f
NM_001351316.2 NP_001338245.1 LETM1 domain-containing protein 1 isoform g
NM_001351317.2 NP_001338246.1 LETM1 domain-containing protein 1 isoform h
NM_001351319.2 NP_001338248.1 LETM1 domain-containing protein 1 isoform d
NM_001351320.2 NP_001338249.1 LETM1 domain-containing protein 1 isoform k
NM_001351321.2 NP_001338250.1 LETM1 domain-containing protein 1 isoform l
NM_001351322.2 NP_001338251.1 LETM1 domain-containing protein 1 isoform m
NM_001351323.2 NP_001338252.1 LETM1 domain-containing protein 1 isoform m
NM_001351324.2 NP_001338253.1 LETM1 domain-containing protein 1 isoform m
NM_001351325.2 NP_001338254.1 LETM1 domain-containing protein 1 isoform n
NM_001351326.2 NP_001338255.1 LETM1 domain-containing protein 1 isoform o
NM_001351327.2 NP_001338256.1 LETM1 domain-containing protein 1 isoform o
NM_001351328.2 NP_001338257.1 LETM1 domain-containing protein 1 isoform p
NM_001351330.2 NP_001338259.1 LETM1 domain-containing protein 1 isoform t
NM_001351332.2 NP_001338261.1 LETM1 domain-containing protein 1 isoform u
NM_001351333.2 NP_001338262.1 LETM1 domain-containing protein 1 isoform q
NM_001351334.2 NP_001338263.1 LETM1 domain-containing protein 1 isoform e
NM_001351335.2 NP_001338264.1 LETM1 domain-containing protein 1 isoform e
NM_001351336.2 NP_001338265.1 LETM1 domain-containing protein 1 isoform e
NM_001351337.2 NP_001338266.1 LETM1 domain-containing protein 1 isoform s
NM_015416.5 NP_056231.3 LETM1 domain-containing protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16762630 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of inflammatory response IMP
IMP: 通过突变表型推断
31980577 GOA
involved in regulation of phagocytosis IMP
IMP: 通过突变表型推断
31980577 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LETMD1 蛋白结构

LETM1

LETM1: LETM1-like protein (79 - 346)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
蛋白主名 其他名称

LETM1 domain-containing protein 1

cervical cancer 1 proto-oncogene protein p40

LETMD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LETMD1 Q6P1Q0 APOC1 Homo sapiens P02654
Y2H Array
32296183
种属内
LETMD1 Q6P1Q0 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
种属内
LETMD1 Q6P1Q0 REEP5 Homo sapiens Q00765
Y2H
16762630
种属内
LETMD1 Q6P1Q0 REEP5 Homo sapiens Q00765
Pull Down
16762630
种属内
LETMD1 Q6P1Q0 REEP5 Homo sapiens Q00765
Anti Tag CoIP
16762630
种属内
LETMD1 Q6P1Q0 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
种属内
LETMD1 Q6P1Q0 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
种属内
LETMD1 Q6P1Q0 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
种属内
LETMD1 Q6P1Q0 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
种属内
LETMD1 Q6P1Q0 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
种属内
LETMD1 Q6P1Q0 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
种属内
LETMD1 Q6P1Q0 APOC4 Homo sapiens P55056
Y2H Array
32296183
种属内
LETMD1 Q6P1Q0 BRI3BP Homo sapiens Q8WY22
Anti Tag CoIP
17943721
种属内
LETMD1 Q6P1Q0 BRI3BP Homo sapiens Q8WY22
Anti Bait CoIP
17943721
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07599 LETMD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LETMD1 VGNC VGNC:74109
Felis catus LETMD1 VGNC VGNC:63216
Canis familiaris LETMD1 VGNC VGNC:42643
Rattus norvegicus LETMD1 RGD RGD:1596738
Mus musculus LETMD1 MGD MGI:1915864
Bos taurus LETMD1 VGNC VGNC:30847
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