1. Gene
  2. DHRSX - dehydrogenase/reductase X-linked Gene

DHRSX - dehydrogenase/reductase X-linked Gene

中文名称:脱氢酶/还原酶 X 连锁

种属: Homo sapiens

同用名: DHRSY; DHRS5X; DHRS5Y; DHRSXY; SDR7C6; CXorf11; SDR46C1

基因 ID: 207063 | 基因类型: protein coding

关于 DHRSX

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:2,219,506-2,500,976 (from NCBI)

This gene has 7 transcripts (splice variants), 164 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 6.0), liver (RPKM 5.1) and 25 other tissues.

功能概要

预测启用氧化还原酶活性。参与自噬的正向调节。位于胞外区。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable oxidoreductase activity. Involved in positive regulation of Autophagy. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

DHRSX 基因产物(1)

mRNA Protein Name
NM_145177.3 NP_660160.2 dehydrogenase/reductase SDR family member on chromosome X
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
25076851 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
25076851 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DHRSX 蛋白结构

adh_short

adh_short: short chain dehydrogenase (45 - 190)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
蛋白主名 其他名称

dehydrogenase/reductase SDR family member on chromosome X

dehydrogenase/reductase (SDR family) X chromosome

DHRSX 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DHRSX Q8N5I4 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra DHRSX Q8N5I4 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra DHRSX Q8N5I4 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra DHRSX Q8N5I4 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra DHRSX Q8N5I4 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra DHRSX Q8N5I4 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra DHRSX Q8N5I4 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra DHRSX Q8N5I4 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra DHRSX Q8N5I4 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra DHRSX Q8N5I4 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra DHRSX Q8N5I4 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 TMEM143 Homo sapiens Q96AN5
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 TMEM143 Homo sapiens Q96AN5
Validated Y2H
32296183
Intra DHRSX Q8N5I4 TMEM143 Homo sapiens Q96AN5
Y2H Array
32296183
Intra DHRSX Q8N5I4 FADS3 Homo sapiens Q9Y5Q0
Y2H Array
32296183
Intra DHRSX Q8N5I4 FADS3 Homo sapiens Q9Y5Q0
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 FADS3 Homo sapiens Q9Y5Q0
Validated Y2H
32296183
Intra DHRSX Q8N5I4 PIGP Homo sapiens P57054
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 PIGP Homo sapiens P57054
Y2H Array
32296183
Intra DHRSX Q8N5I4 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra DHRSX Q8N5I4 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra DHRSX Q8N5I4 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra DHRSX Q8N5I4 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra DHRSX Q8N5I4 ZBED1 Homo sapiens O96006
Anti Tag CoIP
33961781
Intra DHRSX Q8N5I4 ZBED1 Homo sapiens O96006
Anti Tag CoIP
28514442
Intra DHRSX Q8N5I4 RUSF1 Homo sapiens Q96GQ5
Y2H Prey Pooling
32296183
Intra DHRSX Q8N5I4 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra DHRSX Q8N5I4 RUSF1 Homo sapiens Q96GQ5
Y2H Array
32296183
Intra DHRSX Q8N5I4 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra DHRSX Q8N5I4 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra DHRSX Q8N5I4 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Waisman Syndrome

Early-Onset Parkinsonism-Intellectual Disability Syndrome

Bgmr

Wsn

Laxova-Opitz Syndrome

WSMN

Parkinsonism, Early-Onset, With Mental Retardation

Basal Ganglion Disorder With Mental Retardation

Basal Ganglia Disorder With Intellectual Disability

Laxova Brown Hogan Syndrome

X-Linked Recessive Basal Ganglia Disorder With Intellectual Disability

Alpha-Thalassemia Myelodysplasia Syndrome

ATMDS

Acquired Hemoglobin H Disease

Alpha-Thalassemia Myelodysplasia Syndrome, Somatic

Acquired Hbh Disease

Alpha-Thalassemia-Myelodysplastic Syndrome

Hemoglobin H Disease, Acquired

Acquired Alpha-Thalassemia With Myelodysplastic Syndrome

Hemoglobin H Disease Acquired

Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DHRSX VGNC VGNC:54133
Mus musculus DHRSX MGD MGI:2181510
Rattus norvegicus DHRSX RGD RGD:1305017