TUBA1B - tubulin alpha 1b Gene

中文名称：微管蛋白α1b

种属: Homo sapiens

同用名: K-ALPHA-1

基因 ID: 10376 | 基因类型: protein coding

关于 TUBA1B

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,127,782-49,131,395 (from NCBI)

This gene has 8 transcripts (splice variants), 68 orthologues and 23 paralogues. Ubiquitous expression in brain (RPKM 600.4), bone marrow (RPKM 551.8) and 24 other tissues.

功能概要

启用双链 RNA 结合活性和泛素蛋白连接酶结合活性。预计参与微管细胞骨架组织和有丝分裂细胞周期。预测作用于细胞对白细胞介素 4 的反应上游或内部。位于微管中。 [由基因组资源联盟提供，2022 年 4 月]

Enables double-stranded RNA binding activity and ubiquitin protein Ligase binding activity. Predicted to be involved in microtubule Cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]

TUBA1B 基因产物(1)

mRNA	Protein	Name
NM_006082.3	NP_006073.2	tubulin alpha-1B chain

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTP binding	IDA IDA: 通过直接分析推断	34996871	GOA
enables GTPase activity	IDA IDA: 通过直接分析推断	34996871	GOA
enables double-stranded RNA binding	IDA IDA: 通过直接分析推断	21266579	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11698390	GOA
enables structural constituent of cytoskeleton	IDA IDA: 通过直接分析推断	34996871	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	21753002	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in microtubule cytoskeleton organization	IDA IDA: 通过直接分析推断	34996871	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in microtubule	IDA IDA: 通过直接分析推断	21525035	GOA
is active in microtubule cytoskeleton	IDA IDA: 通过直接分析推断	34996871	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TUBA1B 蛋白结构

Tubulin

Tubulin_C

0
100
200
300
400
451 a.a.

蛋白主名

其他名称

tubulin alpha-1B chain

alpha tubulin

关联疾病

疾病名称

别名

Hypoparathyroidism-Retardation-Dysmorphism Syndrome

Sanjad-Sakati Syndrome	Hrd Syndrome
HRDS	Hypoparathyroidism-Intellectual Disability-Dysmorphism Syndrome
Hypoparathyroidism-Short Stature-Intellectual Disability-Seizures Syndrome	Richardson-Kirk Syndrome
Sss	Hypoparathyroidism With Short Stature, Mental Retardation, And Seizures
Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation, And Developmental Delay	Hypoparathyroidism With Short Stature, Mental Retardation And Seizures
Hypoparathyroidism With Short Stature, Intellectual Disability And Seizures	Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation And Developmental Delay

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15246	TUBA1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TUBA1B	RGD	RGD:1565476
Mus musculus	TUBA1B	MGD	MGI:107804

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TUBA1B - tubulin alpha 1b Gene

关于 TUBA1B

功能概要

TUBA1B 基因产物(1)

TUBA1B 蛋白结构

关联疾病

直系同源

热门区域

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TUBA1B - tubulin alpha 1b Gene

关于 TUBA1B

功能概要

TUBA1B 基因产物(1)

TUBA1B 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z