2. Gene
  3. MAL2 - mal, T cell differentiation protein 2 Gene

MAL2 - mal, T cell differentiation protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：mal，T 细胞分化蛋白 2

种属: Homo sapiens

基因 ID: 114569 | 基因类型: protein coding

关于 MAL2

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,208,363-119,245,673 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues and 14 paralogues. Broad expression in esophagus (RPKM 140.3), thyroid (RPKM 100.0) and 16 other tissues.

功能概要

该基因编码属于 MAL 蛋白脂质家族的多跨膜蛋白。该蛋白质是脂筏的组成部分，在极化细胞中，它主要定位于顶膜下方的内体结构。它是转胞吞作用所必需的，转胞吞作用是一种细胞内转运途径，用于将膜结合蛋白和外源性货物从基底外侧输送到顶端表面。[RefSeq 提供，2008 年 7 月]

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]

MAL2 基因产物(1)

mRNA Protein Name
NM_052886.3 NP_443118.1 protein MAL2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12963375 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane raft IDA
IDA: 通过直接分析推断
23264465 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAL2 蛋白结构

MARVEL

MARVEL: Membrane-associating domain (32 - 168)

  • 0
  • 100
  • 176 a.a.
蛋白主名 其他名称

protein MAL2

MAL proteolipid protein 2

MAL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MAL2 Q969L2 SH3GL1 Homo sapiens Q6FGM0
Validated Y2H
25416956
Intra MAL2 Q969L2 SH3GL1 Homo sapiens Q6FGM0
Y2H Array
25416956
Intra MAL2 Q969L2 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra MAL2 Q969L2 PBX3 Homo sapiens Q5JS98
Y2H Array
25416956
Intra MAL2 Q969L2 PBX3 Homo sapiens Q5JS98
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 VARS2 Homo sapiens Q5ST30-3
Validated Y2H
25416956
Intra MAL2 Q969L2 TUBB Homo sapiens Q5SU16
Validated Y2H
25416956
Intra MAL2 Q969L2 TUBB Homo sapiens Q5SU16
Y2H Array
25416956
Intra MAL2 Q969L2 PTPN9 Homo sapiens Q6IQ43
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 FAM3A Homo sapiens Q9BU27
Validated Y2H
25416956
Intra MAL2 Q969L2 POLL Homo sapiens Q9UGP5-2
Validated Y2H
32296183
Intra MAL2 Q969L2 TARS2 Homo sapiens Q9BW92
Validated Y2H
32296183
Intra MAL2 Q969L2 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra MAL2 Q969L2 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra MAL2 Q969L2 NFAM1 Homo sapiens Q8NET5
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 NFAM1 Homo sapiens Q8NET5
Y2H Array
32296183
Intra MAL2 Q969L2 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra MAL2 Q969L2 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra MAL2 Q969L2 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra MAL2 Q969L2 PITPNC1 Homo sapiens Q9UKF7-2
Validated Y2H
32296183
Intra MAL2 Q969L2 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra MAL2 Q969L2 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra MAL2 Q969L2 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra MAL2 Q969L2 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra MAL2 Q969L2 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra MAL2 Q969L2 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra MAL2 Q969L2 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 SUCLA2 Homo sapiens Q9P2R7
Validated Y2H
32296183
Intra MAL2 Q969L2 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32296183
Intra MAL2 Q969L2 CD68 Homo sapiens P34810
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 CD68 Homo sapiens P34810
Y2H Array
32296183
Intra MAL2 Q969L2 ARFIP2 Homo sapiens P53365
Validated Y2H
25416956
Intra MAL2 Q969L2 ARFIP2 Homo sapiens P53365
Y2H Array
25416956
Intra MAL2 Q969L2 ARFIP2 Homo sapiens P53365
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra MAL2 Q969L2 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra MAL2 Q969L2 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra MAL2 Q969L2 TBRG4 Homo sapiens Q969Z0
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Intra MAL2 Q969L2 MIEF1 Homo sapiens Q9NQG6
Validated Y2H
32296183
Intra MAL2 Q969L2 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra MAL2 Q969L2 PTPN9 Homo sapiens P43378
Y2H Array
31515488
Intra MAL2 Q969L2 GAD1 Homo sapiens Q99259
Validated Y2H
32296183
Intra MAL2 Q969L2 RAB37 Homo sapiens Q96AX2
Validated Y2H
25416956
Intra MAL2 Q969L2 RAB37 Homo sapiens Q96AX2
Y2H Array
25416956
Intra MAL2 Q969L2 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra MAL2 Q969L2 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra MAL2 Q969L2 MTERF3 Homo sapiens Q96E29
Validated Y2H
32296183
Intra MAL2 Q969L2 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra MAL2 Q969L2 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra MAL2 Q969L2 GAD2 Homo sapiens Q05329
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 GAD2 Homo sapiens Q05329
Y2H Array
25416956
Intra MAL2 Q969L2 HSFX1 Homo sapiens Q9UBD0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Parasagittal Meningioma
Cerebral Convexity Meningioma

Cerebral Hemispheric Convexity Meningioma
Foster-Kennedy Syndrome

Disorder Of The Optic Nerve

Optic Nerve Diseases

Disease Of Optic Cranial Nerve

Disease Of Optic Nerve

Disease Of Second Cranial Nerve

Disorder Of Optic Cranial Nerve

Disorder Of Second Cranial Nerve

Disorders Of 2nd Nerve
Anterior Cranial Fossa Meningioma

Meningioma Of The Anterior Fossa
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116683 116-9e Inhibitor 98.55% 否
HY-RS07992 MAL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MAL2 VGNC VGNC:84015
Mus musculus MAL2 MGD MGI:2146021
Canis familiaris MAL2 VGNC VGNC:54900
Felis catus MAL2 VGNC VGNC:99808
Bos taurus MAL2 VGNC VGNC:54901
Rattus norvegicus MAL2 RGD RGD:735066
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