2. Gene
  3. AQP3 - aquaporin 3 (Gill blood group) Gene

AQP3 - aquaporin 3 (Gill blood group) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：水通道蛋白 3 (吉尔血型)

种属: Homo sapiens

同用名: GIL; AQP-3

基因 ID: 360 | 基因类型: protein coding

关于 AQP3

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,441,160-33,447,593 (from NCBI)

This gene has 7 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in esophagus (RPKM 430.5), skin (RPKM 178.1) and 9 other tissues.

功能概要

该基因编码水通道蛋白水通道蛋白 3。水通道蛋白是与主要内在蛋白相关的小型完整膜蛋白家族，也称为水通道蛋白 0。水通道蛋白 3 位于肾脏集合管细胞的基底侧膜。除了其水通道功能外，水通道蛋白 3 还被发现有助于非离子小溶质 (如尿素和甘油) 的转运，但程度较小。有人提出，水通道在功能上可以是异质的，并且具有水和溶质渗透机制。该基因的可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2015 年 12 月]

This gene encodes the water channel protein Aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as Aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, Aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

AQP3 基因产物(2)

mRNA Protein Name
NM_001318144.2 NP_001305073.1 aquaporin-3 isoform 2
NM_004925.5 NP_004916.1 aquaporin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycerol channel activity IDA
IDA: 通过直接分析推断
17943189 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables water channel activity EXP
EXP: 通过实验结果推断
9369468 GOA
enables water channel activity IDA
IDA: 通过直接分析推断
30420639 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to hypoxia IDA
IDA: 通过直接分析推断
24462679 GOA
involved in glycerol transmembrane transport IDA
IDA: 通过直接分析推断
30420639 GOA
involved in odontogenesis IEP
IEP: 通过表达模式推断
12522663 GOA
involved in positive regulation of immune system process IDA
IDA: 通过直接分析推断
17943189 GOA
involved in response to retinoic acid IDA
IDA: 通过直接分析推断
17943189 GOA
involved in water transport IDA
IDA: 通过直接分析推断
30420639 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
18718702 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18718702 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
14521551 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AQP3 蛋白结构

MIP

MIP: Major intrinsic protein (20 - 261)

  • 0
  • 100
  • 200
  • 292 a.a.
蛋白主名 其他名称

aquaporin-3

aquaglyceroporin-3

AQP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AQP3 Q92482 VASN Homo sapiens Q6EMK4
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 VASN Homo sapiens Q6EMK4
Y2H Array
32296183
种属内
AQP3 Q92482 SGPL1 Homo sapiens O95470
Y2H Array
32296183
种属内
AQP3 Q92482 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 HIBADH Homo sapiens P31937
Y2H Array
32296183
种属内
AQP3 Q92482 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
种属内
AQP3 Q92482 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
种属内
AQP3 Q92482 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
种属内
AQP3 Q92482 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
AQP3 Q92482 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
种属内
AQP3 Q92482 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
种属内
AQP3 Q92482 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
种属内
AQP3 Q92482 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
种属内
AQP3 Q92482 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
AQP3 Q92482 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
种属内
AQP3 Q92482 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
种属内
AQP3 Q92482 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
种属内
AQP3 Q92482 AQP3 Homo sapiens Q92482
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属内
AQP3 Q92482 CD79A Homo sapiens P11912
Y2H Array
32296183
种属内
AQP3 Q92482 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
种属内
AQP3 Q92482 AQP3 Homo sapiens Q92482
Y2H Array
32296183
种属内
AQP3 Q92482 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
种属内
AQP3 Q92482 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
种属内
AQP3 Q92482 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
种属内
AQP3 Q92482 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
种属内
AQP3 Q92482 STX1A Homo sapiens Q16623
Y2H Array
32296183
种属内
AQP3 Q92482 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

AQP3 抗体

目录号 产品名 应用 反应物种
HY-P81400 Aquaporin 3 Antibody (YA1145) IHC-P Human

关联疾病

疾病名称 别名
Acrokeratoderma, Hereditary Papulotranslucent

Hereditary Papulotranslucent Acrokeratoderma
Oligohydramnios

Oligohydramnios - Delivered

Antepartum Oligohydramnios

Delivered Oligohydramnios

Oligohydramnios, Antepartum Condition Or Complication

Deficient Liquor

Oligohydramnios, Unspecified Trimester

Reduced Liquor Volume
Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus

Diabetes Insipidus, Nephrogenic

Diabetes Insipidus Nephrogenic

Congenital Nephrogenic Diabetes Insipidus

Adh Resistant Diabetes Insipidus

Diabetes Insipidus Nephrogenic X-Linked

Diabetes Insipidus Nephrogenic Type 1

Adh-Resistant Diabetes Insipidus

Diabetes Insipidus Renalis

Ndi

Renal Diabetes Insipidus

Familial Nephrogenic Diabetes

Antidiuretic-Hormone-Resistant Diabetes Insipidus

Adiuretin-Resistant Diabetes Insipidus

Ndi - [Nephrogenic Diabetes Insipidus]

Diabetes Tenuifluus

Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

Hereditary Nephrogenic Diabetes Insipidus

Familial Nephrogenic Diabetes Insipidus

Primary Nephrogenic Diabetes Insipidus
Diabetes Insipidus
Polyhydramnios
Constipation
Hydrarthrosis
Pompholyx

Dyshidrosis

Vesicular Eczema Of Hands And/Or Feet

Cheiropompholyx

Dyshydrotic Eczema

Eczema, Dyshidrotic

Vesicular Hand Eczema
X-Linked Nephrogenic Diabetes Insipidus

Nephrogenic Diabetes Insipidus Type 1

Doid:0081060
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Gestational Diabetes Insipidus

Transient Diabetes Insipidus Of Pregnancy

Diabetes Insipidus Gestational

Gestagenic Diabetes Insipidus

Doid:0081057
Adrenal Gland Pheochromocytoma

Pheochromocytoma
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0557 Bisacodyl Inhibitor 99.59% 是
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126073 DFP00173 99.59% 否
HY-126074 Z433927330 98.11% 否
HY-142980 Dioleoylphosphatidylglycerol / 否
HY-157979 AQP3-IN-1 Inhibitor / 否
HY-RS00875 AQP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AQP3 VGNC VGNC:51701
Mus musculus AQP3 MGD MGI:1333777
Macaca mulatta AQP3 VGNC VGNC:103241
Rattus norvegicus AQP3 RGD RGD:68428
Felis catus AQP3 VGNC VGNC:102901
Bos taurus AQP3 VGNC VGNC:56935
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