2. Gene
  3. SAR1A - secretion associated Ras related GTPase 1A Gene

SAR1A - secretion associated Ras related GTPase 1A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：分泌相关的 Ras 相关 GTPase 1A

种属: Homo sapiens

同用名: SAR1; Sara; SARA1; masra2

基因 ID: 56681 | 基因类型: protein coding

关于 SAR1A

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,147,289-70,170,514 (from NCBI)

This gene has 8 transcripts (splice variants), 121 orthologues and 30 paralogues. Ubiquitous expression in fat (RPKM 47.2), placenta (RPKM 41.9) and 25 other tissues.

功能概要

预测启用 GTPase 活动。参与 COPII 包被的囊泡货物装载。 COPII 囊泡外套的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTPase activity. Involved in COPII-coated vesicle cargo loading. Part of COPII vesicle coat. [provided by Alliance of Genome Resources, Apr 2022]

SAR1A 基因产物(2)

mRNA Protein Name
NM_001142648.2 NP_001136120.1 GTP-binding protein SAR1a
NM_020150.5 NP_064535.1 GTP-binding protein SAR1a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein activity IDA
IDA: 通过直接分析推断
32358066 GOA
enables amino acid sensor activity IDA
IDA: 通过直接分析推断
34290409 GOA
enables amino acid sensor activity IMP
IMP: 通过突变表型推断
34290409 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19181664 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in COPII vesicle coating IDA
IDA: 通过直接分析推断
32358066 GOA
involved in COPII vesicle coating IMP
IMP: 通过突变表型推断
23433038 GOA
involved in COPII-coated vesicle cargo loading IDA
IDA: 通过直接分析推断
17499046 GOA
involved in COPII-coated vesicle cargo loading IMP
IMP: 通过突变表型推断
23433038 GOA
involved in cellular response to leucine starvation IMP
IMP: 通过突变表型推断
34290409 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: 通过直接分析推断
23433038 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
23433038 GOA
NOT involved in lipoprotein transport IDA
IDA: 通过直接分析推断
32358066 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
34290409 GOA
involved in regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
34290409 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COPII vesicle coat IDA
IDA: 通过直接分析推断
17499046 GOA
is active in endoplasmic reticulum exit site IDA
IDA: 通过直接分析推断
23433038 GOA
is active in endoplasmic reticulum exit site IMP
IMP: 通过突变表型推断
23433038 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
34290409 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SAR1A 蛋白结构

Arf

Arf: ADP-ribosylation factor family (12 - 197)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

GTP-binding protein SAR1a

COPII-associated small GTPase

关联疾病

疾病名称 别名
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia Tarda

SEDT

Sed Tarda, X-Linked

Spondyloepiphyseal Dysplasia, Late

Spondyloepiphyseal Dysplasia Tarda X-Linked

Sed

X Linked Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia

Late Onset Spondyloepiphyseal Dysplasia

Sed Tarda

X-Linked Sed

X-Linked Sedt

Dysplasia, Spondyloepiphyseal, Tarda

Spondyloepiphyseal Dysplasia
Chylomicron Retention Disease

CMRD

Anderson Disease

Lipid Transport Defect Of Intestine

Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

Andd

Anderson Syndrome

Crd

Andersons Disease

Malabsorption Syndrome
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Oculomotor Nerve Paralysis

Iii Nerve Palsy

Iiird Nerve Paralysis

Third Cranial Nerve Paralysis
Intracranial Hypotension
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12442 SAR1A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SAR1A VGNC VGNC:76969
Bos taurus SAR1A VGNC VGNC:34286
Rattus norvegicus SAR1A RGD RGD:1359540
Mus musculus SAR1A MGD MGI:98230
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