2. Gene
  3. NAT8 - N-acetyltransferase 8 (putative) Gene

NAT8 - N-acetyltransferase 8 (putative) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-乙酰转移酶 8 (推定的)

种属: Homo sapiens

同用名: GLA; CML1; CCNAT; Hcml1; ATase2; TSC501; TSC510

基因 ID: 9027 | 基因类型: protein coding

关于 NAT8

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,640,723-73,642,422 (from NCBI)

This gene has 1 transcript (splice variant), 344 orthologues and 3 paralogues. Restricted expression toward kidney (RPKM 344.5).

功能概要

该基因使用差异显示方法分离以检测组织特异性基因，在肾脏和肝脏中特异性表达。编码的蛋白质显示出与 N-乙酰转移酶的氨基酸序列相似性。非洲爪蟾中的一种类似蛋白质会影响细胞粘附和原肠胚形成运动，并且可能位于分泌途径中。在具有该基因的簇中发现了高度相似的旁系同源物。[RefSeq 提供，2008 年 9 月]

This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]

NAT8 基因产物(1)

mRNA Protein Name
NM_003960.4 NP_003951.3 N-acetyltransferase 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-S-conjugate N-acetyltransferase activity IDA
IDA: 通过直接分析推断
20392701 GOA
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
IDA: 通过直接分析推断
19011241 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19011241 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-lysine N6-acetylation IDA
IDA: 通过直接分析推断
19011241 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
19011241 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
20392701 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
24556617 GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: 通过直接分析推断
19011241 GOA
located in membrane IDA
IDA: 通过直接分析推断
20392701 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAT8 蛋白结构

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (112 - 194)

  • 0
  • 100
  • 200
  • 227 a.a.
蛋白主名 其他名称

N-acetyltransferase 8

N-acetyltransferase 8 (GCN5-related, putative)

NAT8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NAT8 Q9UHE5 REEP2 Homo sapiens Q9BRK0
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 REEP2 Homo sapiens Q9BRK0
Y2H Array
32296183
Intra NAT8 Q9UHE5 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra NAT8 Q9UHE5 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra NAT8 Q9UHE5 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra NAT8 Q9UHE5 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 TMEM143 Homo sapiens Q96AN5
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMEM143 Homo sapiens Q96AN5
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra NAT8 Q9UHE5 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra NAT8 Q9UHE5 TSPAN31 Homo sapiens Q12999
Y2H Array
32296183
Intra NAT8 Q9UHE5 TSPAN31 Homo sapiens Q12999
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra NAT8 Q9UHE5 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra NAT8 Q9UHE5 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra NAT8 Q9UHE5 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra NAT8 Q9UHE5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra NAT8 Q9UHE5 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra NAT8 Q9UHE5 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra NAT8 Q9UHE5 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra NAT8 Q9UHE5 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra NAT8 Q9UHE5 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 JPH1 Homo sapiens Q9HDC5
Y2H Array
32296183
Intra NAT8 Q9UHE5 JPH1 Homo sapiens Q9HDC5
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra NAT8 Q9UHE5 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra NAT8 Q9UHE5 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra NAT8 Q9UHE5 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 YIPF4 Homo sapiens Q9BSR8
Y2H Array
32296183
Intra NAT8 Q9UHE5 YIPF4 Homo sapiens Q9BSR8
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Iminoglycinuria

Iminoglycinuria, Digenic

IG
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09043 NAT8 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09044 NAT8L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NAT8 MGD MGI:1915646
Rattus norvegicus NAT8 RGD RGD:621609
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