ADGRE2 - adhesion G protein-coupled receptor E2 Gene

中文名称：粘附 G 蛋白偶联受体 E2

种属: Homo sapiens

同用名: VBU; CD97; EMR2; CD312

关于 ADGRE2

功能概要

该基因编码 G 蛋白偶联受体 B 类七跨膜 (TM7) 亚家族的成员。这些蛋白质的特征在于具有可变数量的 N 末端表皮生长因子样结构域的扩展细胞外区域，这些结构域通过粘蛋白样间隔区与 TM7 结构域偶联。编码的蛋白质主要在骨髓细胞中表达，在那里它通过与硫酸软骨素链的相互作用促进细胞间粘附。该基因位于 19 号染色体上的一组相关基因中。已观察到该基因编码多种同种型的可变剪接转录物变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]