1. Gene
  2. ELOVL7 - ELOVL fatty acid elongase 7 Gene

ELOVL7 - ELOVL fatty acid elongase 7 Gene

中文名称:ELOVL 脂肪酸延长酶 7

种属: Homo sapiens

基因 ID: 79993 | 基因类型: protein coding

关于 ELOVL7

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:60,751,791-60,844,269 (from NCBI)

This gene has 7 transcripts (splice variants), 230 orthologues and 6 paralogues. Broad expression in prostate (RPKM 8.7), skin (RPKM 7.9) and 18 other tissues.

功能概要

启用脂肪酸延长酶活性。参与脂肪酸延伸,多不饱和脂肪酸;脂肪酸延伸,饱和脂肪酸;和极长链脂肪酸的生物合成过程。位于内质网。 [由基因组资源联盟提供,2022 年 4 月]

Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ELOVL7 基因产物(4)

mRNA Protein Name
NM_001104558.2 NP_001098028.1 elongation of very long chain fatty acids protein 7 isoform 1
NM_001297617.2 NP_001284546.1 elongation of very long chain fatty acids protein 7 isoform 2
NM_001297618.2 NP_001284547.1 elongation of very long chain fatty acids protein 7 isoform 3
NM_024930.3 NP_079206.2 elongation of very long chain fatty acids protein 7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fatty acid elongase activity EXP
EXP: 通过实验结果推断
19826053 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20937905 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid elongation, polyunsaturated fatty acid IDA
IDA: 通过直接分析推断
20937905 GOA
involved in fatty acid elongation, saturated fatty acid IDA
IDA: 通过直接分析推断
19826053 GOA
involved in very long-chain fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
19826053 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
20937905 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ELOVL7 蛋白结构

ELO

ELO: GNS1/SUR4 family (30 - 265)

  • 0
  • 100
  • 200
  • 281 a.a.
蛋白主名 其他名称

elongation of very long chain fatty acids protein 7

3-keto acyl-CoA synthase ELOVL7

ELOVL7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ELOVL7 A1L3X0 RTP2 Homo sapiens Q5QGT7 32296183
种属内
ELOVL7 A1L3X0 SYNJ2BP Homo sapiens P57105 32296183
种属内
ELOVL7 A1L3X0 ADGRE2 Homo sapiens Q9UHX3 32296183
种属内
ELOVL7 A1L3X0 VAMP1 Homo sapiens P23763-3 32296183
种属内
ELOVL7 A1L3X0 SLC41A1 Homo sapiens Q8IVJ1 32296183
种属内
ELOVL7 A1L3X0 SERF1A Homo sapiens O75920 32296183
种属内
ELOVL7 A1L3X0 TMEM14C Homo sapiens Q9P0S9 32296183
种属内
ELOVL7 A1L3X0 UBE2J2 Homo sapiens Q8N2K1 32296183
种属内
ELOVL7 A1L3X0 EMP3 Homo sapiens P54852 32296183
种属内
ELOVL7 A1L3X0 DTNBP1 Homo sapiens Q96EV8 25416956
种属内
ELOVL7 A1L3X0 LRCH4 Homo sapiens O75427 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 38

Spinocerebellar Ataxia Type 38

SCA38

Ataxia, Spinocerebellar, Type 38

Spinocerebellar Ataxia 34

Erythrokeratodermia With Ataxia

Spinocerebellar Ataxia Type 34

SCA34

Erythrokeratodermia - Ataxia

Giroux Barbeau Syndrome

Spinocerebellar Ataxia And Erythrokeratodermia

Erythrokeratodermia Ataxia

Spastic Quadriplegia

Spastic Quadriplegic Cerebral Palsy

Quadriplegic Infantile Cerebral Palsy

Tetraplegic Infantile Cerebral Palsy

Cerebral Palsy Spastic Quadriplegic

Quadriplegic Cerebral Palsy

Spastic Quadriplegia Cerebral Palsy

Spastic Tetraplegia Cerebral Palsy

Cerebral Palsy, Quadriplegic, Infantile

Cerebral Palsy With Spastic Tetraplegia

Congenital Spastic Quadriplegia

Spastic Tetraplegic Cerebral Palsy

Congenital Quadriplegia Nos

Tetraplegic Cerebral Palsy

Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis

Erythrokeratodermia Variabilis Et Progressiva

Greither Disease

Ekv

Ekvp

PSEK

Erythrokeratodermia Variabilis With Erythema Gyratum Repens

Keratosis Palmoplantaris Transgrediens Et Progrediens

Transgrediens Et Progrediens Palmoplantar Keratoderma

EKVP1

Erythrokeratodermia, Progressive Symmetric

Erythrokeratodermia Figurata, Congenital Familial, In Plaques

Keratoderma Palmoplantaris Transgrediens

Keratosis Extremitatum Hereditaria Progrediens

Erythrokeratodermia Variabilis, Mendes Da Costa Type

Progressive Symmetric Erythrokeratodermia

Erythrokeratodermia Figurata Variabilis

Greither'S Disease

Ekv-P

Erythrokeratodermia Variabilis Of Mendes Da Costa

Progressive Symmetrical Erythrokeratoderma Of Gottron

Progressive Diffuse Ppk

Progressive Diffuse Palmoplantar Keratoderma

Transgrediens Et Progrediens Ppk

Darier-Gottron Disease

Erythrokeratodermia Progressiva Symmetrica

Progressive Symmetric Erythrokeratodermia, Gottron Type

Congenital Familial Erythrokeratodermia Figurata In Plaques

Erythrokeratodermia Progressive Symmetric

Erythrokeratodermia Variabilis Mendes Da Costa Type

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ELOVL7 VGNC VGNC:72117
Felis catus ELOVL7 VGNC VGNC:61825
Mus musculus ELOVL7 MGD MGI:1921809
Rattus norvegicus ELOVL7 RGD RGD:1310560
Canis familiaris ELOVL7 VGNC VGNC:40325
Bos taurus ELOVL7 VGNC VGNC:28453