LRCH4 - leucine rich repeats and calponin homology domain containing 4 Gene

中文名称：含富亮氨酸的重复序列和 calponin 同源域 4

种属: Homo sapiens

同用名: LRN; LRRN1; LRRN4; PP14183

基因 ID: 4034 | 基因类型: protein coding

关于 LRCH4

This gene has 10 transcripts (splice variants), 92 orthologues and 31 paralogues. Broad expression in testis (RPKM 33.5), spleen (RPKM 31.2) and 25 other tissues.

功能概要

该基因编码的蛋白质在其氨基末端含有富含亮氨酸的重复序列 (LRR) ，并且已知该蛋白质参与配体结合。羧基末端可以作为膜锚。已识别的结构元素表明编码的蛋白质类似于受体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

LRCH4 基因产物(2)

mRNA	Protein	Name
NM_001289934.2	NP_001276863.1	leucine-rich repeat and calponin homology domain-containing protein 4 isoform 2
NM_002319.5	NP_002310.2	leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRCH4 蛋白结构

LRR_8

LRR_1

0
200
400
600
683 a.a.

蛋白主名

其他名称

leucine-rich repeat and calponin homology domain-containing protein 4

leucine rich repeat neuronal 4

LRCH4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	LRCH4	O75427	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	LRCH4	O75427	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	LRCH4	O75427	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	LRCH4	O75427	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	LRCH4	O75427	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	LRCH4	O75427	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	LRCH4	O75427	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	LRCH4	O75427	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	LRCH4	O75427	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	ELOVL7	Homo sapiens	A1L3X0	Y2H Array	32296183
Intra	LRCH4	O75427	ELOVL7	Homo sapiens	A1L3X0	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	CYB5R3	Homo sapiens	P00387	Validated Y2H	32296183
Intra	LRCH4	O75427	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	LRCH4	O75427	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	LRCH4	O75427	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	LRCH4	O75427	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	RNASEK	Homo sapiens	Q6P5S7	Validated Y2H	32296183
Intra	LRCH4	O75427	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	LRCH4	O75427	DOCK7	Homo sapiens	Q96N67	Anti Tag CoIP	24255178
Intra	LRCH4	O75427	DOCK8	Homo sapiens	Q8NF50-3	Anti Tag CoIP	32203420
Intra	LRCH4	O75427	SUGT1	Homo sapiens	Q9Y2Z0	Anti Tag CoIP	24255178
Intra	LRCH4	O75427	DOCK6	Homo sapiens	Q96HP0	Anti Tag CoIP	32203420
Intra	LRCH4	O75427	MDFI	Homo sapiens	Q99750	Y2H Pooling	16189514
Intra	LRCH4	O75427	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	LRCH4	O75427	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	LRCH4	O75427	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	LRCH4	O75427	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Brittle Cornea Syndrome 1

Brittle Cornea Syndrome	Fragilitas Oculi With Joint Hyperextensibility
Dysgenesis Mesodermalis Corneae Et Sclerae	BCS1
Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility	Ehlers-Danlos Syndrome, Type Vib, Formerly
Eds6b, Formerly	Type Vib Ehlers-Danlos Syndrome
Eds Vib	Ehlers-Danlos Syndrome Type 6b
Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility	Eds6b Formerly
Ehlers-Danlos Syndrome Type Vib Formerly	Ehlers-Danlos Syndrome Type 6
Cornea, Brittle, Syndrome	Cornea, Brittle, Syndrome, Type 1
Ehlers-Danlos Syndrome 6b

Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy	Ppcd
Maumenee Corneal Dystrophy	Posterior Polymorphous Corneal Dystrophy 1
PPCD1	Corneal Dystrophy, Hereditary Polymorphous Posterior
Corneal Endothelial Dystrophy 1, Autosomal Dominant	Schlichting Dystrophy
Ched1	Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly
Ched1, Formerly	Hereditary Polymorphus Posterior Corneal Dystrophy
Posterior Polymorphous Dystrophy	Hereditary Polymorphous Posterior Corneal Dystrophy
Dystrophy, Corneal, Posterior Polymorphous	Dystrophy, Corneal, Posterior Polymorphous, Type 1
Polymorphous Corneal Dystrophy	Corneal Endothelial Dystrophy 2

Differentiating Neuroblastoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07780	LRCH4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	LRCH4	RGD	RGD:1306145
Bos taurus	LRCH4	VGNC	VGNC:30974
Macaca mulatta	LRCH4	VGNC	VGNC:74441
Canis familiaris	LRCH4	VGNC	VGNC:42759
Mus musculus	LRCH4	MGD	MGI:1917193
Felis catus	LRCH4	VGNC	VGNC:68086

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