SYNJ2BP - synaptojanin 2 binding protein Gene

中文名称：突触结合蛋白 2 结合蛋白

种属: Homo sapiens

同用名: ARIP2; OMP25

基因 ID: 55333 | 基因类型: protein coding

关于 SYNJ2BP

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,366,499-70,417,090 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 23.3), duodenum (RPKM 20.4) and 24 other tissues.

功能概要

预测启用 II 型激活素受体结合活性。参与多个过程，包括内皮细胞迁移的负调节；萌芽血管生成的负调节；和信号转导的调节。位于线粒体中。是线粒体外膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable type II activin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of sprouting angiogenesis; and regulation of signal transduction. Located in mitochondrion. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYNJ2BP 基因产物(1)

mRNA	Protein	Name
NM_018373.3	NP_060843.2	synaptojanin-2-binding protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24025447	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	24025447	GOA
involved in negative regulation of angiogenesis	IMP IMP: 通过突变表型推断	24025447	GOA
involved in negative regulation of endothelial cell migration	IMP IMP: 通过突变表型推断	24025447	GOA
involved in negative regulation of endothelial cell proliferation	IMP IMP: 通过突变表型推断	24025447	GOA
involved in negative regulation of sprouting angiogenesis	IMP IMP: 通过突变表型推断	24025447	GOA
involved in regulation of Notch signaling pathway	IMP IMP: 通过突变表型推断	24025447	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	32973005	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	18845145	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SYNJ2BP 蛋白结构

PDZ

0
100
145 a.a.

蛋白主名

其他名称

synaptojanin-2-binding protein

activin receptor interacting protein 5

SYNJ2BP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SYNJ2BP	P57105	THEM5	Homo sapiens	Q8N1Q8	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	THEM5	Homo sapiens	Q8N1Q8	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	THEM5	Homo sapiens	Q8N1Q8	Y2H Array	32296183
种属内	SYNJ2BP	P57105	ELOVL7	Homo sapiens	A1L3X0	Y2H Array	32296183
种属内	SYNJ2BP	P57105	ELOVL7	Homo sapiens	A1L3X0	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	TMEM242	Homo sapiens	Q9NWH2	Y2H Array	32296183
种属内	SYNJ2BP	P57105	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	MEDAG	Homo sapiens	Q5VYS4	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	MEDAG	Homo sapiens	Q5VYS4	Y2H Array	32296183
种属内	SYNJ2BP	P57105	MEDAG	Homo sapiens	Q5VYS4	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	ELOVL5	Homo sapiens	Q9NYP7	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	ELOVL5	Homo sapiens	Q9NYP7	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	ELOVL5	Homo sapiens	Q9NYP7	Y2H Array	32296183
种属内	SYNJ2BP	P57105	DLL4	Homo sapiens	Q9NR61	Anti Bait CoIP	24025447
种属内	SYNJ2BP	P57105	DLL4	Homo sapiens	Q9NR61	Lumier	24025447
种属内	SYNJ2BP	P57105	DLL4	Homo sapiens	Q9NR61	Confocal	24025447
种属内	SYNJ2BP	P57105	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
种属内	SYNJ2BP	P57105	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	SYNJ2BP	P57105	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
种属内	SYNJ2BP	P57105	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
种属内	SYNJ2BP	P57105	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
种属内	SYNJ2BP	P57105	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
种属内	SYNJ2BP	P57105	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
种属内	SYNJ2BP	P57105	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	EBP	Homo sapiens	Q15125	Y2H Array	32296183
种属内	SYNJ2BP	P57105	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
种属内	SYNJ2BP	P57105	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
种属内	SYNJ2BP	P57105	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
种属内	SYNJ2BP	P57105	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
种属内	SYNJ2BP	P57105	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
种属内	SYNJ2BP	P57105	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	CD79A	Homo sapiens	P11912	Y2H Array	32296183
种属内	SYNJ2BP	P57105	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
种属内	SYNJ2BP	P57105	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
种属内	SYNJ2BP	P57105	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
种属内	SYNJ2BP	P57105	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
种属内	SYNJ2BP	P57105	CYB561	Homo sapiens	P49447	Y2H Array	32296183
种属内	SYNJ2BP	P57105	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Brucellosis

Mediterranean Fever	Malta Fever
Undulant Fever	Gibraltar Fever
Bang'S Disease	Maltese Fever
Cyprus Fever	Rock Fever
Brucellosis Infection	Brucella Infection

Colorectal Cancer, Hereditary Nonpolyposis, Type 7

HNPCC7	Hereditary Nonpolyposis Colorectal Cancer Type 7
Hereditary Non-Polyposis Colorectal Cancer 7	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7

Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities

IDDSSBA

Trench Fever

His-Werner Disease	Quintan Fever
Shin Bone Fever	Wolhynian Fever
Tibialgic Fever	Bartonellosis Due To Bartonella Quintana Infection
Febris Quintata	Five Day Fever
Fever Due To Rickettsia Quintana	Febris Quintana
Fever Due To Bartonella Quintana	Fever Due To Rochalimaea Quintana
Meuse Fever

Bacillary Angiomatosis

Angiomatosis, Bacillary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14095	SYNJ2BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SYNJ2BP	RGD	RGD:69400
Mus musculus	SYNJ2BP	MGD	MGI:1344347

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