SLC7A8 - solute carrier family 7 member 8 Gene

中文名称：溶质载体家族 7 成员 8

种属: Homo sapiens

同用名: LAT2; LPI-PC1

基因 ID: 23428 | 基因类型: protein coding

关于 SLC7A8

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,125,295-23,183,660 (from NCBI)

This gene has 13 transcripts (splice variants), 258 orthologues and 12 paralogues. Broad expression in kidney (RPKM 77.2), prostate (RPKM 18.0) and 18 other tissues.

功能概要

启用多种功能，包括中性氨基酸跨膜转运蛋白活性；甲状腺激素跨膜转运体活性；和毒素跨膜转运蛋白活性。参与 L-丙氨酸跨质膜输入； L-亮氨酸跨质膜导入；和甲状腺激素的运输。位于质膜。基底外侧质膜和微绒毛膜的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including neutral amino acid transmembrane transporter activity; thyroid hormone transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in L-alanine import across plasma membrane; L-leucine import across plasma membrane; and thyroid hormone transport. Located in plasma membrane. Part of basolateral plasma membrane and microvillus membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A8 基因产物(4)

mRNA	Protein	Name
NM_001267036.1	NP_001253965.1	large neutral amino acids transporter small subunit 2 isoform c
NM_001267037.2	NP_001253966.1	large neutral amino acids transporter small subunit 2 isoform d
NM_012244.4	NP_036376.2	large neutral amino acids transporter small subunit 2 isoform a
NM_182728.3	NP_877392.1	large neutral amino acids transporter small subunit 2 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables L-alanine transmembrane transporter activity	IGI IGI: 通过遗传相互作用推断	10391915	GOA
enables L-leucine transmembrane transporter activity	IDA IDA: 通过直接分析推断	19075510	GOA
enables L-leucine transmembrane transporter activity	IGI IGI: 通过遗传相互作用推断	10391915	GOA
enables amino acid transmembrane transporter activity	EXP EXP: 通过实验结果推断	10391915	GOA
enables amino acid transmembrane transporter activity	IDA IDA: 通过直接分析推断	10391915	GOA
enables antiporter activity	IDA IDA: 通过直接分析推断	11847106	GOA
enables neutral L-amino acid transmembrane transporter activity	IDA IDA: 通过直接分析推断	11847106	GOA
enables neutral L-amino acid transmembrane transporter activity	IMP IMP: 通过突变表型推断	26050671	GOA
enables organic cation transmembrane transporter activity	IDA IDA: 通过直接分析推断	12117417	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12716892	GOA
enables protein heterodimerization activity	IDA IDA: 通过直接分析推断	33298890	GOA
enables thyroid hormone transmembrane transporter activity	IDA IDA: 通过直接分析推断	26305885	GOA
enables toxin transmembrane transporter activity	IDA IDA: 通过直接分析推断	12117417	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in L-alanine import across plasma membrane	IGI IGI: 通过遗传相互作用推断	10391915	GOA
involved in L-leucine import across plasma membrane	IDA IDA: 通过直接分析推断	19075510	GOA
involved in L-leucine import across plasma membrane	IGI IGI: 通过遗传相互作用推断	10391915	GOA
involved in L-leucine import across plasma membrane	IMP IMP: 通过突变表型推断	26050671	GOA
involved in amino acid import across plasma membrane	IDA IDA: 通过直接分析推断	26305885	GOA
involved in amino acid transport	IDA IDA: 通过直接分析推断	10391915	GOA
involved in neutral amino acid transport	IDA IDA: 通过直接分析推断	11847106	GOA
involved in thyroid hormone transport	IDA IDA: 通过直接分析推断	26305885	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in basal plasma membrane	IDA IDA: 通过直接分析推断	26050671	GOA
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	15918515	GOA
located in microvillus membrane	IDA IDA: 通过直接分析推断	26050671	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10391915	GOA
located in plasma membrane	IGI IGI: 通过遗传相互作用推断	10391915	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC7A8 蛋白结构

AA_permease_2

0
100
200
300
400
500
535 a.a.

蛋白主名

其他名称

large neutral amino acids transporter small subunit 2

L-type amino acid transporter 2

SLC7A8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLC7A8	Q9UHI5	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	SLC7A8	Q9UHI5	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	SLC7A8	Q9UHI5	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	SLC7A8	Q9UHI5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC7A8	Q9UHI5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC7A8	Q9UHI5	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	SLC7A8	Q9UHI5	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	SLC7A8	Q9UHI5	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	SLC7A8	Q9UHI5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	SLC7A8	Q9UHI5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	SLC7A8	Q9UHI5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	SLC7A8	Q9UHI5	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	SLC7A8	Q9UHI5	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	SLC7A8	Q9UHI5	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	SLC7A8	Q9UHI5	HSPA5	Homo sapiens	P11021	Y2H Pooling	32814053
Intra	SLC7A8	Q9UHI5	HSPA5	Homo sapiens	P11021	Validated Y2H	32814053
Intra	SLC7A8	Q9UHI5	HSPA5	Homo sapiens	P11021	Y2H Array	32814053
Intra	SLC7A8	Q9UHI5	HSPA2	Homo sapiens	P54652	Y2H Pooling	32814053
Intra	SLC7A8	Q9UHI5	HSPA2	Homo sapiens	P54652	Validated Y2H	32814053
Intra	SLC7A8	Q9UHI5	HSPA2	Homo sapiens	P54652	Y2H Array	32814053
Intra	SLC7A8	Q9UHI5	YIPF6	Homo sapiens	Q96EC8	Y2H Prey Pooling	32296183
Intra	SLC7A8	Q9UHI5	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	SLC7A8	Q9UHI5	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	SLC7A8	Q9UHI5	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183
Intra	SLC7A8	Q9UHI5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SLC7A8	Q9UHI5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lysinuric Protein Intolerance

LPI	Dibasic Amino Aciduria Ii
Hyperdibasic Aminoaciduria	Dibasic Aminoaciduria 2
Dibasicamino Aciduria Ii	Congenital Lysinuria
Lpi - Lysinuric Protein Intolerance

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

Allan-Herndon-Dudley Syndrome

AHDS	Allan-Herndon Syndrome
Monocarboxylate Transporter 8 Deficiency	MCT8 DEFICIENCY
Mental Retardation, X-Linked, With Hypotonia	Triiodothyronine Resistance
T3 Resistance	Mental Retardation And Muscular Atrophy
Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency	Intellectual Disability And Muscular Atrophy
Monocarboxylate Transporter-8 Deficiency	T3 Resisitence
Triiodothyronine Resistence	X-Linked Intellectual Disability With Hypotonia
Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency	Monocarboxylate Transporter 8 Deficiency
X-Linked Intellectual Disability-Hypotonia Syndrome

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13335	SLC7A8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SLC7A8	RGD	RGD:619904
Mus musculus	SLC7A8	MGD	MGI:1355323
Macaca mulatta	SLC7A8	VGNC	VGNC:77632
Canis familiaris	SLC7A8	VGNC	VGNC:46478
Felis catus	SLC7A8	VGNC	VGNC:80842
Bos taurus	SLC7A8	VGNC	VGNC:34933

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC7A8 - solute carrier family 7 member 8 Gene

关于 SLC7A8

功能概要

SLC7A8 基因产物(4)

SLC7A8 蛋白结构

SLC7A8 蛋白互作信息

关联疾病

直系同源

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SLC7A8 - solute carrier family 7 member 8 Gene

关于 SLC7A8

功能概要

SLC7A8 基因产物(4)

SLC7A8 蛋白结构

SLC7A8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z