CALN1 - calneuron 1 Gene

中文名称：钙神经元 1

种属: Homo sapiens

同用名: CABP8

基因 ID: 83698 | 基因类型: protein coding

关于 CALN1

Cytogenetic location: 7q11.22 Genomic coordinates (GRCh38): 7:71,779,491-72,504,279 (from NCBI)

This gene has 6 transcripts (splice variants), 277 orthologues and 20 paralogues. Biased expression in brain (RPKM 8.4), adrenal (RPKM 3.0) and 1 other tissue.

功能概要

该基因编码的蛋白质与钙调蛋白家族的钙结合蛋白高度相似。编码的蛋白质包含两个 EF 手域和潜在的钙结合位点。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with high similarity to the calcium-binding proteins of the Calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CALN1 基因产物(3)

mRNA	Protein	Name
NM_001017440.3	NP_001017440.1	calcium-binding protein 8 isoform 2
NM_001363460.1	NP_001350389.1	calcium-binding protein 8 isoform 2
NM_031468.4	NP_113656.2	calcium-binding protein 8 isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in trans-Golgi network membrane	IDA IDA: 通过直接分析推断	19338761	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CALN1 蛋白结构

EF-hand_7

0
100
200
219 a.a.

蛋白主名

其他名称

calcium-binding protein 8

calcium-binding protein CABP8

CALN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
种属内	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
种属内	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
种属内	CALN1	Q9BXU9	SLPI	Homo sapiens	P03973	Y2H Prey Pooling	32296183
种属内	CALN1	Q9BXU9	SLPI	Homo sapiens	P03973	Y2H Array	32296183
种属内	CALN1	Q9BXU9	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
种属内	CALN1	Q9BXU9	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
种属内	CALN1	Q9BXU9	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

D-Glyceric Aciduria

D-Glyceric Acidemia	D-Glycericacidemia
Glycerate Kinase Deficiency	D-Glycerate Kinase Deficiency
Non Ketotic Hyperglycinemia Syndrome	Deficiency Of Glycerate Kinase
Hyperglycinemia, Non-Ketotic	D-GA

Deafness, Autosomal Recessive 39

DFNB39	Autosomal Recessive Nonsyndromic Deafness 39
Autosomal Recessive Deafness 39	Deafness, Autosomal Recessive, 39
Congenital Neurosensory Deafness Autosomal Recessive 39	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39	Deafness, Autosomal Recessive, Type 39

Drug Psychosis

Drug-Induced Psychosis	Drug-Induced Psychotic Disorder
Psychoses, Substance-Induced	Psychoses, Drug

Drug-Induced Mental Disorder

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01846	CALN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CALN1	VGNC	VGNC:82078
Mus musculus	CALN1	MGD	MGI:2155987
Rattus norvegicus	CALN1	RGD	RGD:1305843
Canis familiaris	CALN1	VGNC	VGNC:38674
Bos taurus	CALN1	VGNC	VGNC:26714

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