2. Gene
  3. VAMP2 - vesicle associated membrane protein 2 Gene

VAMP2 - vesicle associated membrane protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：囊泡相关膜蛋白 2

种属: Homo sapiens

同用名: SYB2; VAMP-2; NEDHAHM

基因 ID: 6844 | 基因类型: protein coding

关于 VAMP2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,159,147-8,162,948 (from NCBI)

This gene has 4 transcripts (splice variants), 153 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues.

功能概要

该基因编码的蛋白质是囊泡相关膜蛋白 (VAMP) /synaptobrevin 家族的成员。 Synaptobrevins/VAMPs、突触融合蛋白和 25-kD 突触体相关蛋白 SNAP25 是参与突触小泡与突触前膜的对接和/或融合的蛋白复合物的主要成分。该基因被认为参与了对接和融合之间的神经递质释放。该蛋白质与突触融合蛋白、突触体相关蛋白、25 kD 和突触结合蛋白形成稳定的复合物。它还与突触素形成独特的复合物。它可能是家族性婴儿肌无力 (FIMG) 的候选基因，因为它位于地图位置，并且因为它编码的突触小泡蛋白类型与 FIMG 的发病机制有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

VAMP2 基因产物(2)

mRNA Protein Name
NM_001330125.1 NP_001317054.1 vesicle-associated membrane protein 2 isoform 2
NM_014232.3 NP_055047.2 vesicle-associated membrane protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9920726 GOA
enables syntaxin binding IPI
IPI: 通过物理相互作用推断
12855681 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in eosinophil degranulation IMP
IMP: 通过突变表型推断
16677249 GOA
NOT involved in mucus secretion IMP
IMP: 通过突变表型推断
22144578 GOA
NOT involved in natural killer cell degranulation IMP
IMP: 通过突变表型推断
18042464 GOA
NOT involved in neutrophil degranulation IMP
IMP: 通过突变表型推断
16677249 GOA
NOT involved in regulation of histamine secretion by mast cell IMP
IMP: 通过突变表型推断
18253931 GOA
involved in vesicle fusion IMP
IMP: 通过突变表型推断
30929742 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SNARE complex IDA
IDA: 通过直接分析推断
12130530 GOA
located in clathrin-coated vesicle IDA
IDA: 通过直接分析推断
19478182 GOA
located in membrane IDA
IDA: 通过直接分析推断
16677249 GOA
NOT located in secretory granule membrane IDA
IDA: 通过直接分析推断
16677249 GOA
located in vesicle IDA
IDA: 通过直接分析推断
17313651 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VAMP2 蛋白结构

Synaptobrevin

Synaptobrevin: Synaptobrevin (28 - 114)

  • 0
  • 100
  • 116 a.a.
蛋白主名 其他名称

vesicle-associated membrane protein 2

synaptobrevin 2

VAMP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VAMP2 P63027 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
Intra VAMP2 P63027 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra VAMP2 P63027 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra VAMP2 P63027 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra VAMP2 P63027 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 VMA21 Homo sapiens Q3ZAQ7
Validated Y2H
32296183
Intra VAMP2 P63027 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra VAMP2 P63027 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra VAMP2 P63027 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra VAMP2 P63027 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 HIBADH Homo sapiens P31937
Y2H Array
32296183
Intra VAMP2 P63027 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra VAMP2 P63027 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 PRKD3 Homo sapiens O94806
Pull Down
17196367
Intra VAMP2 P63027 PRKD3 Homo sapiens O94806
Anti Tag CoIP
17196367
Intra VAMP2 P63027 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra VAMP2 P63027 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra VAMP2 P63027 MARCHF8 Homo sapiens Q5T0T0
Validated Y2H
32296183
Intra VAMP2 P63027 MARCHF8 Homo sapiens Q5T0T0
Y2H Array
32296183
Intra VAMP2 P63027 MARCHF8 Homo sapiens Q5T0T0
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra VAMP2 P63027 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra VAMP2 P63027 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra VAMP2 P63027 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra VAMP2 P63027 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra VAMP2 P63027 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra VAMP2 P63027 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra VAMP2 P63027 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra VAMP2 P63027 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 VCP Homo sapiens P55072
Y2H Array
32814053
Intra VAMP2 P63027 VCP Homo sapiens P55072
Y2H Pooling
32814053
Intra VAMP2 P63027 VCP Homo sapiens P55072
Validated Y2H
32814053
Intra VAMP2 P63027 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra VAMP2 P63027 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra VAMP2 P63027 TMEM101 Homo sapiens Q96IK0
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 TMEM101 Homo sapiens Q96IK0
Validated Y2H
32296183
Intra VAMP2 P63027 TMEM101 Homo sapiens Q96IK0
Y2H Array
32296183
Intra VAMP2 P63027 SNAP29 Homo sapiens O95721
Y2H Prey Pooling
25416956
Intra VAMP2 P63027 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra VAMP2 P63027 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra VAMP2 P63027 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra VAMP2 P63027 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra VAMP2 P63027 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra VAMP2 P63027 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra VAMP2 P63027 STX1A Homo sapiens Q16623
Anti Bait CoIP
20798282
Intra VAMP2 P63027 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra VAMP2 P63027 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra VAMP2 P63027 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra VAMP2 P63027 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra VAMP2 P63027 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra VAMP2 P63027 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra VAMP2 P63027 STX1B Homo sapiens P61266
Y2H Prey Pooling
32296183
Intra VAMP2 P63027 STX1B Homo sapiens P61266
Y2H Array
32296183
Intra VAMP2 P63027 SNCA Homo sapiens P37840
Anti Bait CoIP
20798282
Intra VAMP2 P63027 SNCA Homo sapiens P37840
Pull Down
20798282
Intra VAMP2 P63027 SNCA Homo sapiens P37840
Density Sedimentation
20798282
Cross VAMP2 P63027 F Clostridium botulinum A7GBG3
Protease Assay
22172278
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Hypotonia And Autistic Features With Or Without Hyperkinetic Movements

NEDHAHM

Neurodevelopmental Disorder, Hypotonia And Autistic Features With/Without Hyperkinetic Movements
Tetanus

Lockjaw

Clostridial Tetanus

Infection Due To Clostridium Tetani

Lock-Jaw
Foodborne Botulism

Botulism

Botulism Poisoning

Intoxication With Clostridium Botulinum Toxin

Wound Botulism

Food Poisoning Due To Clostridium Botulinum

Infection Due To Clostridium Botulinum

Infant Botulism

Intoxication Botulism

Botulism, Infantile

Clostridium Botulinum Poisoning

Botulism Nos
Infant Botulism

Infant Intestinal Botulism

Infant Intestinal Toxemia Botulism

Infant Intestinal Toxin-Mediated Botulism

Infantile Botulism

Botulism, Infantile
Partial Optic Atrophy
Wound Botulism

Cutaneous Infectious Botulism

Cutaneous Toxin-Mediated Botulism

Inoculation Botulism

Skin Infectious Botulism

Skin Toxin-Mediated Botulism
Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia
Primary Bacterial Infectious Disease
Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15594 VAMP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus VAMP2 MGD MGI:1313277
Rattus norvegicus VAMP2 RGD RGD:3949
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