2. Gene
  3. BET1 - Bet1 golgi vesicular membrane trafficking protein Gene

BET1 - Bet1 golgi vesicular membrane trafficking protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Bet1 高尔基体囊泡膜转运蛋白

种属: Homo sapiens

同用名: HBET1

基因 ID: 10282 | 基因类型: protein coding

关于 BET1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,962,762-94,004,355 (from NCBI)

This gene has 8 transcripts (splice variants) and 76 orthologues. Ubiquitous expression in placenta (RPKM 6.4), adrenal (RPKM 5.3) and 25 other tissues.

功能概要

该基因编码参与从内质网 (ER) 到高尔基复合体的囊泡运输的高尔基体相关膜蛋白。编码的蛋白质作为可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体发挥作用，可能参与 ER 衍生囊泡与顺式高尔基体膜的对接。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

BET1 基因产物(2)

mRNA Protein Name
NM_001317739.2 NP_001304668.1 BET1 homolog isoform 2
NM_005868.6 NP_005859.1 BET1 homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
34779586 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cis-Golgi network IDA
IDA: 通过直接分析推断
34779586 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
34779586 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BET1 蛋白结构

SNARE

SNARE: SNARE domain (31 - 90)

  • 0
  • 100
  • 118 a.a.
蛋白主名 其他名称

BET1 homolog

Bet1p homolog

BET1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BET1 O15155 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra BET1 O15155 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra BET1 O15155 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra BET1 O15155 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra BET1 O15155 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra BET1 O15155 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra BET1 O15155 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
Intra BET1 O15155 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra BET1 O15155 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra BET1 O15155 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra BET1 O15155 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra BET1 O15155 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra BET1 O15155 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra BET1 O15155 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra BET1 O15155 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra BET1 O15155 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra BET1 O15155 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra BET1 O15155 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra BET1 O15155 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra BET1 O15155 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra BET1 O15155 TMEM35A Homo sapiens Q53FP2
Validated Y2H
32296183
Intra BET1 O15155 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra BET1 O15155 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra BET1 O15155 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra BET1 O15155 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra BET1 O15155 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra BET1 O15155 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra BET1 O15155 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra BET1 O15155 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra BET1 O15155 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra BET1 O15155 STX2 Homo sapiens P32856-2
Validated Y2H
32296183
Intra BET1 O15155 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra BET1 O15155 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra BET1 O15155 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
Intra BET1 O15155 CD74 Homo sapiens P04233-2
Validated Y2H
32296183
Intra BET1 O15155 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra BET1 O15155 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra BET1 O15155 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
Intra BET1 O15155 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
Intra BET1 O15155 ASZ1 Homo sapiens Q8WWH4
Validated Y2H
32296183
Intra BET1 O15155 ASGR2 Homo sapiens P07307-3
Validated Y2H
32296183
Intra BET1 O15155 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra BET1 O15155 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra BET1 O15155 SLC26A6 Homo sapiens Q9BXS9-3
Y2H Prey Pooling
32296183
Intra BET1 O15155 SLC26A6 Homo sapiens Q9BXS9-3
Validated Y2H
32296183
Intra BET1 O15155 SLC26A6 Homo sapiens Q9BXS9-3
Y2H Array
32296183
Intra BET1 O15155 TMCO5A Homo sapiens Q8N6Q1
Y2H Prey Pooling
32296183
Intra BET1 O15155 TMCO5A Homo sapiens Q8N6Q1
Validated Y2H
32296183
Intra BET1 O15155 TMCO5A Homo sapiens Q8N6Q1
Y2H Array
32296183
Intra BET1 O15155 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra BET1 O15155 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra BET1 O15155 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra BET1 O15155 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra BET1 O15155 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra BET1 O15155 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra BET1 O15155 LYPD5 Homo sapiens Q6UWN5
Y2H Array
32296183
Intra BET1 O15155 LYPD5 Homo sapiens Q6UWN5
Validated Y2H
32296183
Intra BET1 O15155 LYPD5 Homo sapiens Q6UWN5
Y2H Prey Pooling
32296183
Intra BET1 O15155 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra BET1 O15155 CRB3 Homo sapiens Q9BUF7-2
Validated Y2H
32296183
Intra BET1 O15155 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra BET1 O15155 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra BET1 O15155 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra BET1 O15155 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra BET1 O15155 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra BET1 O15155 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra BET1 O15155 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra BET1 O15155 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra BET1 O15155 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra BET1 O15155 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra BET1 O15155 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra BET1 O15155 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra BET1 O15155 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra BET1 O15155 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra BET1 O15155 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra BET1 O15155 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra BET1 O15155 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra BET1 O15155 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra BET1 O15155 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra BET1 O15155 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra BET1 O15155 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra BET1 O15155 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra BET1 O15155 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra BET1 O15155 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra BET1 O15155 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra BET1 O15155 CLEC10A Homo sapiens Q8IUN9
Validated Y2H
32296183
Intra BET1 O15155 CLEC10A Homo sapiens Q8IUN9
Y2H Prey Pooling
32296183
Intra BET1 O15155 CLEC10A Homo sapiens Q8IUN9
Y2H Array
32296183
Intra BET1 O15155 ADORA2A Homo sapiens P29274
Y2H Prey Pooling
32296183
Intra BET1 O15155 ADORA2A Homo sapiens P29274
Validated Y2H
32296183
Intra BET1 O15155 ADORA2A Homo sapiens P29274
Y2H Array
32296183
Intra BET1 O15155 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra BET1 O15155 GOSR2 Homo sapiens O14653
Pull Down
29568061
Intra BET1 O15155 GOSR2 Homo sapiens O14653
Y2H Prey Pooling
32296183
Intra BET1 O15155 GOSR2 Homo sapiens O14653
Anti Tag CoIP
33961781
Intra BET1 O15155 GOSR2 Homo sapiens O14653
BioID
29568061
Intra BET1 O15155 GOSR2 Homo sapiens O14653
Y2H Array
32296183
Intra BET1 O15155 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra BET1 O15155 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra BET1 O15155 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra BET1 O15155 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra BET1 O15155 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra BET1 O15155 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra BET1 O15155 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra BET1 O15155 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra BET1 O15155 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra BET1 O15155 ANKS6 Homo sapiens Q68DC2
Validated Y2H
32296183
Intra BET1 O15155 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra BET1 O15155 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra BET1 O15155 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra BET1 O15155 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra BET1 O15155 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra BET1 O15155 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra BET1 O15155 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra BET1 O15155 USHBP1 Homo sapiens Q8N6Y0
Pull Down
16189514
Intra BET1 O15155 USHBP1 Homo sapiens Q8N6Y0
Y2H Pooling
16189514
Intra BET1 O15155 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra BET1 O15155 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra BET1 O15155 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra BET1 O15155 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra BET1 O15155 STX4 Homo sapiens Q12846
Validated Y2H
25416956
Intra BET1 O15155 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra BET1 O15155 STX4 Homo sapiens Q12846
Y2H Prey Pooling
25416956
Intra BET1 O15155 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra BET1 O15155 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra BET1 O15155 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra BET1 O15155 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra BET1 O15155 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra BET1 O15155 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra BET1 O15155 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra BET1 O15155 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra BET1 O15155 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra BET1 O15155 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra BET1 O15155 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra BET1 O15155 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra BET1 O15155 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra BET1 O15155 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra BET1 O15155 CYB561 Homo sapiens P49447
Validated Y2H
32296183
Intra BET1 O15155 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra BET1 O15155 STX1B Homo sapiens P61266
Y2H Prey Pooling
32296183
Intra BET1 O15155 STX1B Homo sapiens P61266
Validated Y2H
32296183
Intra BET1 O15155 STX1B Homo sapiens P61266
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Citrullinemia, Type Ii, Neonatal-Onset

NICCD

Citrin Deficiency

Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency

Citrullinemia, Type Ii, Neonatal-Onset, With Or Without Failure To Thrive And Dyslipidemia

Cholestasis, Neonatal Intrahepatic, Caused By Citrin Deficiency

Neonatal-Onset Type Ii Citrullinemia

Neonatal Intrahepatic Cholestasis Caused By Citrin Deficiency

Neonatal-Onset Citrullinemia Type 2

Neonatal-Onset Citrullinemia Type Ii

Neonatal-Onset Type 2 Citrullinemia

Adult-Onset Citrullinemia Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135250B Thalidomide-4-O-C6-NH2 hydrochloride Inducer 98.53% 否
HY-142265 NVS-BET-1 Inhibitor / 否
HY-135250A Thalidomide-4-O-C6-NH2 TFA Inducer / 否
HY-136794 SB-284851-BT Inhibitor / 否
HY-157749 Thalidomide-piperazine-(S)-CH2-pyrrolidine-C2-O-CH2-COO-C(CH3)3 Inducer / 否
HY-RS01478 BET1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01479 BET1L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus BET1 VGNC VGNC:26475
Rattus norvegicus BET1 RGD RGD:2203
Mus musculus BET1 MGD MGI:1343104
Macaca mulatta BET1 VGNC VGNC:80799
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