1. Gene
  2. PTGES - prostaglandin E synthase Gene

PTGES - prostaglandin E synthase Gene

中文名称:前列腺素 E 合酶

种属: Homo sapiens

同用名: PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1

基因 ID: 9536 | 基因类型: protein coding

关于 PTGES

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,738,349-129,753,042 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 1 paralogue. Biased expression in placenta (RPKM 28.7), urinary bladder (RPKM 13.8) and 12 other tissues.

功能概要

该基因编码的蛋白质是谷胱甘肽依赖性前列腺素 E 合酶。该基因的表达已被证明是由促炎细胞因子白细胞介素 1 β (IL1B) 诱导的。其表达也可被抑癌蛋白 TP53 诱导,并可能参与 TP53 诱导的细胞凋亡。小鼠基因敲除研究表明,该基因可能有助于胶原蛋白诱导的关节炎的发病机制,并在炎症反应期间介导急性疼痛。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced Apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

PTGES 基因产物(1)

mRNA Protein Name
NM_004878.5 NP_004869.1 prostaglandin E synthase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutathione binding IDA
IDA: 通过直接分析推断
18682561 GOA
enables glutathione peroxidase activity IDA
IDA: 通过直接分析推断
12244105 GOA
enables glutathione transferase activity IDA
IDA: 通过直接分析推断
12672824 GOA
enables prostaglandin-E synthase activity IDA
IDA: 通过直接分析推断
18682561 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in prostaglandin biosynthetic process IDA
IDA: 通过直接分析推断
18682561 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
18682561 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTGES 蛋白结构

MAPEG

MAPEG: MAPEG family (17 - 146)

  • 0
  • 100
  • 152 a.a.
蛋白主名 其他名称

prostaglandin E synthase

MGST1-like 1

PTGES 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTGES O14684 VAPB Homo sapiens O95292
Validated Y2H
32296183
种属内
PTGES O14684 GIMAP1 Homo sapiens Q8WWP7
Validated Y2H
32296183
种属内
PTGES O14684 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
种属内
PTGES O14684 EHHADH Homo sapiens Q08426
Y2H Array
32296183
种属内
PTGES O14684 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
种属内
PTGES O14684 YIF1A Homo sapiens O95070
Validated Y2H
32296183
种属内
PTGES O14684 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
种属内
PTGES O14684 PLP2 Homo sapiens Q04941
Validated Y2H
32296183
种属内
PTGES O14684 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
种属内
PTGES O14684 TMEM65 Homo sapiens Q6PI78
Validated Y2H
32296183
种属内
PTGES O14684 VAMP3 Homo sapiens Q15836
Validated Y2H
32296183
种属内
PTGES O14684 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
种属内
PTGES O14684 VAMP4 Homo sapiens O75379
Validated Y2H
32296183
种属内
PTGES O14684 BET1 Homo sapiens O15155
Validated Y2H
32296183
种属内
PTGES O14684 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
种属内
PTGES O14684 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
种属内
PTGES O14684 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

PTGES 抗体

目录号 产品名 应用 反应物种
HY-P81996 Prostaglandin E Synthase Antibody (YA1741) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Gastric Ulcer

Stomach Ulcer

Acute Gastric Ulcer With Haemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

Acute Gastric Ulcer With Hemorrhage, With Obstruction

Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

Acute Gastric Ulcer With Perforation

Acute Gastric Ulcer With Perforation And Obstruction

Acute Gastric Ulcer With Perforation, With Obstruction

Acute Gastric Ulcer Without Hemorrhage And Without Perforation

Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

Bleeding Acute Gastric Ulcer

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

Gastric Ulcers

Cushings Ulcer

Cushing'S Ulcer Of Stomach

Peptic Ulcer Of Stomach

Mucosal Defect Of The Stomach

Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux

Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Endometrial Disease

Endometrial Disorder

Endometrial Diseases

Diamond-Blackfan Anemia 1

Aase Syndrome

DBA1

Erythrogenesis Imperfecta

Aase-Smith Syndrome Ii

Dba

Blackfan-Diamond Syndrome

Bds

Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

Anemia, Congenital Erythroid Hypoplastic

Red Cell Aplasia, Pure, Hereditary

Aregenerative Anemia, Chronic Congenital

Rps19-Related Diamond-Blackfan Anemia

Chronic Congenital Aregenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Pure Hereditary Red Cell Aplasia

Anemia, Diamond-Blackfan, Type 1

Anemia, Diamond-Blackfan

Aase Smith Syndrome 2

Familial Hypoplastic Anaemia With Malformations

Constitutional Pure Red Cell Aplasia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PTGES MGD MGI:1927593
Canis familiaris PTGES VGNC VGNC:45145
Rattus norvegicus PTGES RGD RGD:62076
Macaca mulatta PTGES VGNC VGNC:76471
Felis catus PTGES VGNC VGNC:69142
Bos taurus PTGES VGNC VGNC:33505