2. Gene
  3. TMEM65 - transmembrane protein 65 Gene

TMEM65 - transmembrane protein 65 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜蛋白 65

种属: Homo sapiens

基因 ID: 157378 | 基因类型: protein coding

关于 TMEM65

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,306,189-124,372,701 (from NCBI)

This gene has 7 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in duodenum (RPKM 11.1), brain (RPKM 8.4) and 25 other tissues.

功能概要

预计参与心室发育和心脏传导调节。位于闰盘内；线粒体内膜；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in cardiac ventricle development and regulation of cardiac conduction. Located in intercalated disc; mitochondrial inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM65 基因产物(1)

mRNA Protein Name
NM_194291.3 NP_919267.2 transmembrane protein 65
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in intercalated disc IDA
IDA: 通过直接分析推断
26403541 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
24765583 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
26403541 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMEM65 蛋白结构

TMEM65

TMEM65: Transmembrane protein 65 (120 - 227)

  • 0
  • 100
  • 200
  • 240 a.a.
蛋白主名 其他名称

transmembrane protein 65

TMEM65 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TMEM65 Q6PI78 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra TMEM65 Q6PI78 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra TMEM65 Q6PI78 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra TMEM65 Q6PI78 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra TMEM65 Q6PI78 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra TMEM65 Q6PI78 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra TMEM65 Q6PI78 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra TMEM65 Q6PI78 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra TMEM65 Q6PI78 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra TMEM65 Q6PI78 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra TMEM65 Q6PI78 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra TMEM65 Q6PI78 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra TMEM65 Q6PI78 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra TMEM65 Q6PI78 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra TMEM65 Q6PI78 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra TMEM65 Q6PI78 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra TMEM65 Q6PI78 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra TMEM65 Q6PI78 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 IGSF9 Homo sapiens Q9P2J2-2
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 IGSF9 Homo sapiens Q9P2J2-2
Validated Y2H
32296183
Intra TMEM65 Q6PI78 IGSF9 Homo sapiens Q9P2J2-2
Y2H Array
32296183
Intra TMEM65 Q6PI78 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra TMEM65 Q6PI78 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 IL3RA Homo sapiens P26951
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 IL3RA Homo sapiens P26951
Y2H Array
32296183
Intra TMEM65 Q6PI78 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra TMEM65 Q6PI78 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra TMEM65 Q6PI78 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra TMEM65 Q6PI78 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra TMEM65 Q6PI78 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra TMEM65 Q6PI78 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra TMEM65 Q6PI78 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra TMEM65 Q6PI78 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra TMEM65 Q6PI78 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra TMEM65 Q6PI78 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 PVR Homo sapiens P15151
Y2H Array
32296183
Intra TMEM65 Q6PI78 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 TMEM101 Homo sapiens Q96IK0
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 TMEM101 Homo sapiens Q96IK0
Validated Y2H
32296183
Intra TMEM65 Q6PI78 TMEM101 Homo sapiens Q96IK0
Y2H Array
32296183
Intra TMEM65 Q6PI78 JPH1 Homo sapiens Q9HDC5
Validated Y2H
32296183
Intra TMEM65 Q6PI78 JPH1 Homo sapiens Q9HDC5
Y2H Array
32296183
Intra TMEM65 Q6PI78 JPH1 Homo sapiens Q9HDC5
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra TMEM65 Q6PI78 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra TMEM65 Q6PI78 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra TMEM65 Q6PI78 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra TMEM65 Q6PI78 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra TMEM65 Q6PI78 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra TMEM65 Q6PI78 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra TMEM65 Q6PI78 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra TMEM65 Q6PI78 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra TMEM65 Q6PI78 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra TMEM65 Q6PI78 MSMO1 Homo sapiens Q15800
Y2H Prey Pooling
32296183
Intra TMEM65 Q6PI78 MSMO1 Homo sapiens Q15800
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mitochondrial Complex Iv Deficiency, Nuclear Type 5

Leigh Syndrome, French Canadian Type

Mitochondrial Complex V Deficiency Nuclear Type 4

Cytochrome C Oxidase Deficiency, French Canadian Type

Lsfc

Cox Deficiency, French Canadian Type

MC5DN4

MC4DN5

Cox Deficiency, Saguenay-Lac-Saint-Jean Type

Leigh Syndrome, Saguenay-Lac-Saint-Jean Type

Mitochondrial Complex V Deficiency, Nuclear Type 4

French Canadian Leigh Disease

Leigh Syndrome, French-Canadian Type

Leigh Syndrome , French Canadian Type

Mitochondrial Complex V Deficiency, Atp5a1 Type

French Canadian Type Cox Deficiency

French Canadian Type Cytochrome C Oxidase Deficiency

French Canadian Type Leigh Syndrome

Saguenay Lac Saint Jean Type Cox Deficiency

Saguenay Lac Saint Jean Type Leigh Syndrome

Cox Deficiency, Saguenay Lac Saint Jean Type

Leigh Syndrome, Saguenay Lac Saint Jean Type

Mitochondrial Complex V Deficiency, Nuclear Type 4

Mitochondrial Complex V Deficiency Atp5a1 Type

Mitochondrial Complex V Deficiency Type 4

Mitochondrial Complex V Deficiency, Nuclear, Type 4
Progressive Familial Heart Block

Hereditary Bundle Branch Defect

Hereditary Bundle Branch System Defect

Familial Lenegre Disease

Familial Lev Disease

Familial Lev-Lenegre Disease

Familial Pccd

Familial Progressive Heart Block

Pfhb

Bundle Branch Block

Hbbd

Lenegre Lev Disease

Lev Syndrome

Lev'S Disease

Lev-Lenègre Disease

Pccd

Progressive Cardiac Conduction Defect

Bundle-Branch Block
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14736 TMEM65 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TMEM65 VGNC VGNC:47598
Bos taurus TMEM65 VGNC VGNC:36106
Macaca mulatta TMEM65 VGNC VGNC:104502
Rattus norvegicus TMEM65 RGD RGD:1563224
Mus musculus TMEM65 MGD MGI:1922118
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