2. Gene
  3. CYBRD1 - cytochrome b reductase 1 Gene

CYBRD1 - cytochrome b reductase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞色素 b 还原酶 1

种属: Homo sapiens

同用名: DCYTB; FRRS3; CYB561A2

基因 ID: 79901 | 基因类型: protein coding

关于 CYBRD1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:171,522,233-171,558,129 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 155.0), small intestine (RPKM 130.0) and 22 other tissues.

功能概要

该基因是编码铁调节蛋白的细胞色素 b (561) 家族的成员。它在十二指肠刷状缘膜中高表达。它具有铁还原酶活性，被认为在膳食铁吸收中发挥生理作用。[RefSeq 提供，2008 年 7 月]

This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]

CYBRD1 基因产物(3)

mRNA Protein Name
NM_001127383.2 NP_001120855.1 plasma membrane ascorbate-dependent reductase CYBRD1 isoform 2
NM_001256909.2 NP_001243838.1 plasma membrane ascorbate-dependent reductase CYBRD1 isoform 3
NM_024843.4 NP_079119.3 plasma membrane ascorbate-dependent reductase CYBRD1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
30272000 GOA
enables oxidoreductase activity, acting on metal ions IDA
IDA: 通过直接分析推断
14499595 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables transmembrane ascorbate ferrireductase activity IDA
IDA: 通过直接分析推断
17068337 GOA
enables transmembrane monodehydroascorbate reductase activity IDA
IDA: 通过直接分析推断
17068337 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ascorbate homeostasis IDA
IDA: 通过直接分析推断
17068337 GOA
involved in intracellular iron ion homeostasis IDA
IDA: 通过直接分析推断
14499595 GOA
involved in multicellular organismal-level iron ion homeostasis IDA
IDA: 通过直接分析推断
30272000 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
12949720 GOA
located in brush border membrane IDA
IDA: 通过直接分析推断
12949720 GOA
located in membrane IDA
IDA: 通过直接分析推断
30272000 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17068337 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYBRD1 蛋白结构

Cytochrom_B561

Cytochrom_B561: Eukaryotic cytochrome b561 (49 - 185)

  • 0
  • 100
  • 200
  • 286 a.a.
蛋白主名 其他名称

plasma membrane ascorbate-dependent reductase CYBRD1

cytochrome b561 family, member A2

CYBRD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CYBRD1 Q53TN4 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra CYBRD1 Q53TN4 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra CYBRD1 Q53TN4 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra CYBRD1 Q53TN4 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra CYBRD1 Q53TN4 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra CYBRD1 Q53TN4 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra CYBRD1 Q53TN4 PRPF40A Homo sapiens O75400-2
Validated Y2H
32814053
Intra CYBRD1 Q53TN4 PRPF40A Homo sapiens O75400-2
Y2H Array
32814053
Intra CYBRD1 Q53TN4 PRPF40A Homo sapiens O75400-2
Y2H Pooling
32814053
Intra CYBRD1 Q53TN4 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 TMEM65 Homo sapiens Q6PI78
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 CASP6 Homo sapiens P55212
Validated Y2H
32814053
Intra CYBRD1 Q53TN4 CASP6 Homo sapiens P55212
Y2H Array
32814053
Intra CYBRD1 Q53TN4 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
Intra CYBRD1 Q53TN4 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 STX4 Homo sapiens Q12846
Validated Y2H
25910212
Intra CYBRD1 Q53TN4 STX4 Homo sapiens Q12846
Y2H Array
25910212
Intra CYBRD1 Q53TN4 STX4 Homo sapiens Q12846
Y2H
21516116
Intra CYBRD1 Q53TN4 STX4 Homo sapiens Q12846
Y2H Bait-Prey Pool
25910212
Intra CYBRD1 Q53TN4 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra CYBRD1 Q53TN4 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
Iron Metabolism Disease

Iron Deficiency

Iron Disorder

Iron Metabolism Disorders

Disorder Of Iron Metabolism

Iron

Fe Deficiency

Iron Storage Disease

Iron Storage Disorder
Porphyria Cutanea Tarda

Hepatoerythropoietic Porphyria

HEP

Uroporphyrinogen Decarboxylase Deficiency

Pct

Pct, Type Ii

Porphyria, Hepatocutaneous Type

Urod Deficiency

Porphyria, Hepatoerythropoietic

Porphyria Cutanea Tarda, Susceptibility To

Familial Porphyria Cutanea Tarda

Porphyria Cutanea Tarda, Type Ii

Pct, 'Familial' Type

Porphyria, Hepatic

FPCT

Pct Type Ii

Porphyria Cutanea Tarda Type Ii

Porphyria Hepatocutaneous Type

Heterozygous Uroporphyrinogen Decarboxylase Deficiency

Urod - [Uroporphyrinogen Decarboxylase] Deficiency

Pct - [Porphyria Cutanea Tarda]
Porphyria

Hematoporphyria

Porphyrias

Disorder Of Porphyrin And Hem Metabolism

Disorder Of Porphyrin Metabolism

Porphyrinopathy

Porphyrin Disorder

Disorder Of Porphyrin And Heme Metabolism

Disorders Of Porphyrin Metabolism
Hemochromatosis, Type 4

Hemochromatosis Type 4

Hemochromatosis Due To Defect In Ferroportin

HFE4

Hemochromatosis, Autosomal Dominant

Autosomal Dominant Hereditary Hemochromatosis

Ferroportin Disease

Hemochromatosis 4

Hemochromatosis Autosomal Dominant
Iron Overload In Africa

African Iron Overload

Bantu Siderosis

African Hemochromatosis

Hereditary Iron Overload And African Americans

African Nutritional Hemochromatosis

African Siderosis
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder
Anemia, Sideroblastic, 1

Xlsa

X-Linked Sideroblastic Anemia

Hypochromic Anemia

Anh1

Hereditary Iron-Loading Anemia

Anemia, Sideroblastic, X-Linked

Anemia, Hereditary Sideroblastic

Erythroid 5-Aminolevulinate Synthase Deficiency

Hereditary Sideroblastic Anemia

SIDBA1

Anemia, Hypochromic

Sideroblastic Anemia 1

Anemia Hypochromic

X Chromosome-Linked Sideroblastic Anemia

Sideroblastic Anaemia 1

X-Linked Sideroblastic Anaemia

Anemia Hereditary Sideroblastic

Anemia Sex-Linked Hypochromic Sideroblastic

Congenital Sideroblastic Anemia

Sideroblastic Anemia X-Linked

Anemia, Sex-Linked Hypochromic Sideroblastic

Congenital Sideroblastic Anaemia

X-Linked Pyridoxine-Responsive Sideroblastic Anemia

Anemia Congenital Sideroblastic

Anemia, Sideroblastic, Type 1

Sex-Linked Hypochromic Sideroblastic Anaemia

Autosomal Recessive Sideroblastic Anaemia

Familial Sex Linked Hypochromic Anaemia
Hemochromatosis Type 2

Juvenile Hemochromatosis

Juvenile Hereditary Hemochromatosis

Hfe2

Jhh

Hemochromatosis Juvenile

Iron Overload Disease Juvenile

Hemochromatosis, Juvenile

Hemochromatosis, Type 2

Hemochromatosis

Hemochromatosis, Type 1
Iron Deficiency Anemia

Iron-Deficiency Anemia

Fe Deficiency Anaemia

Ida - [Iron Deficiency Anemia]

Fe - [Iron] Deficiency Anemia Nos
Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
Beta-Thalassemia Major

Cooley'S Anemia

Cooley Anemia

Mediterranean Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03427 CYBRD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CYBRD1 VGNC VGNC:80178
Mus musculus CYBRD1 MGD MGI:2654575
Macaca mulatta CYBRD1 VGNC VGNC:104520
Canis familiaris CYBRD1 VGNC VGNC:50286
Rattus norvegicus CYBRD1 RGD RGD:1305740
Bos taurus CYBRD1 VGNC VGNC:49050
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z