VAMP4 - vesicle associated membrane protein 4 Gene

中文名称：囊泡相关膜蛋白 4

种属: Homo sapiens

同用名: VAMP-4; VAMP24

基因 ID: 8674 | 基因类型: protein coding

关于 VAMP4

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,700,160-171,742,065 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 10 paralogues. Ubiquitous expression in brain (RPKM 9.9), testis (RPKM 7.1) and 25 other tissues.

功能概要

Synaptobrevins/VAMPs、突触融合蛋白和 25-kD 突触体相关蛋白 SNAP25 是参与突触小泡与突触前膜的对接和/或融合的蛋白复合物的主要成分。该基因编码的蛋白质是囊泡相关膜蛋白 (VAMP) /synaptobrevin 家族的成员。这种蛋白质可能在跨高尔基体网络到内体的运输中发挥作用。[RefSeq 提供，2008 年 7 月]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]

VAMP4 基因产物(2)

mRNA	Protein	Name
NM_001185127.2	NP_001172056.1	vesicle-associated membrane protein 4 isoform 2
NM_003762.5	NP_003753.2	vesicle-associated membrane protein 4 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SNARE complex assembly	IDA IDA: 通过直接分析推断	21151919	GOA
involved in endocytic recycling	IMP IMP: 通过突变表型推断	23677696	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	23677696	GOA
located in cell surface	IDA IDA: 通过直接分析推断	21151919	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VAMP4 蛋白结构

Synaptobrevin

0
100
141 a.a.

蛋白主名

其他名称

vesicle-associated membrane protein 4

VAMP4/TAF3 fusion

VAMP4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	VAMP4	O75379	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	32296183
种属内	VAMP4	O75379	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
种属内	VAMP4	O75379	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
种属内	VAMP4	O75379	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
种属内	VAMP4	O75379	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	26359495
种属内	VAMP4	O75379	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	33961781
种属内	VAMP4	O75379	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
种属内	VAMP4	O75379	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
种属内	VAMP4	O75379	CYB5R3	Homo sapiens	P00387	Validated Y2H	32296183
种属内	VAMP4	O75379	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
种属内	VAMP4	O75379	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	PTGES	Homo sapiens	O14684	Y2H Array	32296183
种属内	VAMP4	O75379	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
种属内	VAMP4	O75379	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
种属内	VAMP4	O75379	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
种属内	VAMP4	O75379	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
种属内	VAMP4	O75379	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
种属内	VAMP4	O75379	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
种属内	VAMP4	O75379	STOM	Homo sapiens	P27105	Validated Y2H	32296183
种属内	VAMP4	O75379	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	STOM	Homo sapiens	P27105	Y2H Array	32296183
种属内	VAMP4	O75379	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
种属内	VAMP4	O75379	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	VAMP4	O75379	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
种属内	VAMP4	O75379	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
种属内	VAMP4	O75379	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
种属内	VAMP4	O75379	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
种属内	VAMP4	O75379	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
种属内	VAMP4	O75379	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
种属内	VAMP4	O75379	EVI2B	Homo sapiens	P34910-2	Validated Y2H	32296183
种属内	VAMP4	O75379	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
种属内	VAMP4	O75379	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
种属内	VAMP4	O75379	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
种属内	VAMP4	O75379	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
种属内	VAMP4	O75379	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
种属内	VAMP4	O75379	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
种属内	VAMP4	O75379	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
种属内	VAMP4	O75379	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
种属内	VAMP4	O75379	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
种属内	VAMP4	O75379	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
种属内	VAMP4	O75379	STX6	Homo sapiens	O43752	Anti Tag CoIP	25419848
种属内	VAMP4	O75379	STX6	Homo sapiens	O43752	Anti Tag CoIP	19557002
种属内	VAMP4	O75379	STX6	Homo sapiens	O43752	Anti Tag CoIP	33961781
种属内	VAMP4	O75379	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	SEC11C	Homo sapiens	Q9BY50	Validated Y2H	32296183
种属内	VAMP4	O75379	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183
种属内	VAMP4	O75379	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
种属内	VAMP4	O75379	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	EBP	Homo sapiens	Q15125	Y2H Array	32296183
种属内	VAMP4	O75379	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
种属内	VAMP4	O75379	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
种属内	VAMP4	O75379	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
种属内	VAMP4	O75379	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
种属内	VAMP4	O75379	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
种属内	VAMP4	O75379	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
种属内	VAMP4	O75379	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
种属内	VAMP4	O75379	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
种属内	VAMP4	O75379	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
种属内	VAMP4	O75379	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
种属内	VAMP4	O75379	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	ANKS6	Homo sapiens	Q68DC2	Y2H Array	32296183
种属内	VAMP4	O75379	ANKS6	Homo sapiens	Q68DC2	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	ANKS6	Homo sapiens	Q68DC2	Validated Y2H	32296183
种属内	VAMP4	O75379	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
种属内	VAMP4	O75379	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
种属内	VAMP4	O75379	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	MGST3	Homo sapiens	O14880	Y2H Array	32296183
种属内	VAMP4	O75379	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
种属内	VAMP4	O75379	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
种属内	VAMP4	O75379	STX4	Homo sapiens	Q12846	Y2H Array	32296183
种属内	VAMP4	O75379	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	STX4	Homo sapiens	Q12846	Anti Tag CoIP	33961781
种属内	VAMP4	O75379	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
种属内	VAMP4	O75379	STX4	Homo sapiens	Q12846	Y2H Array	25416956
种属内	VAMP4	O75379	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
种属内	VAMP4	O75379	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
种属内	VAMP4	O75379	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
种属内	VAMP4	O75379	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	VAMP4	O75379	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
种属内	VAMP4	O75379	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
种属内	VAMP4	O75379	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183
种属内	VAMP4	O75379	SYT2	Homo sapiens	Q8N9I0	Validated Y2H	32296183
种属内	VAMP4	O75379	STX16	Homo sapiens	O14662-5	Y2H Array	32296183
种属内	VAMP4	O75379	STX16	Homo sapiens	O14662-5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Infant Botulism

Infant Intestinal Botulism	Infant Intestinal Toxemia Botulism
Infant Intestinal Toxin-Mediated Botulism	Infantile Botulism
Botulism, Infantile

Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2	Pontocerebellar Hypoplasia Type 2e
Pch2	PCH2E
Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy	Pontocerebellar Hypoplasia 2e
Pcca2	Progressive Cerebello-Cerebral Atrophy Type 2
Doid:0112328	Hypoplasia, Pontocerebellar, Type 2e
Pontocerebellar Hypoplasia, Type 2d	Pontocerebellar Hypoplasia Type 2a

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15596	VAMP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	VAMP4	VGNC	VGNC:107961
Bos taurus	VAMP4	VGNC	VGNC:36758
Rattus norvegicus	VAMP4	RGD	RGD:1309753
Mus musculus	VAMP4	MGD	MGI:1858730
Canis familiaris	VAMP4	VGNC	VGNC:48224
Macaca mulatta	VAMP4	VGNC	VGNC:78752

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