2. Gene
  3. VAMP4 - vesicle associated membrane protein 4 Gene

VAMP4 - vesicle associated membrane protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：囊泡相关膜蛋白 4

种属: Homo sapiens

同用名: VAMP-4; VAMP24

基因 ID: 8674 | 基因类型: protein coding

关于 VAMP4

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,700,160-171,742,065 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 10 paralogues. Ubiquitous expression in brain (RPKM 9.9), testis (RPKM 7.1) and 25 other tissues.

功能概要

Synaptobrevins/VAMPs、突触融合蛋白和 25-kD 突触体相关蛋白 SNAP25 是参与突触小泡与突触前膜的对接和/或融合的蛋白复合物的主要成分。该基因编码的蛋白质是囊泡相关膜蛋白 (VAMP) /synaptobrevin 家族的成员。这种蛋白质可能在跨高尔基体网络到内体的运输中发挥作用。[RefSeq 提供，2008 年 7 月]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]

VAMP4 基因产物(2)

mRNA Protein Name
NM_001185127.2 NP_001172056.1 vesicle-associated membrane protein 4 isoform 2
NM_003762.5 NP_003753.2 vesicle-associated membrane protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SNARE complex assembly IDA
IDA: 通过直接分析推断
21151919 GOA
involved in endocytic recycling IMP
IMP: 通过突变表型推断
23677696 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
23677696 GOA
located in cell surface IDA
IDA: 通过直接分析推断
21151919 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VAMP4 蛋白结构

Synaptobrevin

Synaptobrevin: Synaptobrevin (50 - 136)

  • 0
  • 100
  • 141 a.a.
蛋白主名 其他名称

vesicle-associated membrane protein 4

VAMP4/TAF3 fusion

VAMP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VAMP4 O75379 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
32296183
Intra VAMP4 O75379 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra VAMP4 O75379 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra VAMP4 O75379 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra VAMP4 O75379 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
26359495
Intra VAMP4 O75379 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
33961781
Intra VAMP4 O75379 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra VAMP4 O75379 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra VAMP4 O75379 CYB5R3 Homo sapiens P00387
Validated Y2H
32296183
Intra VAMP4 O75379 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra VAMP4 O75379 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra VAMP4 O75379 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra VAMP4 O75379 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra VAMP4 O75379 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra VAMP4 O75379 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra VAMP4 O75379 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra VAMP4 O75379 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra VAMP4 O75379 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra VAMP4 O75379 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 STOM Homo sapiens P27105
Y2H Array
32296183
Intra VAMP4 O75379 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra VAMP4 O75379 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra VAMP4 O75379 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra VAMP4 O75379 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra VAMP4 O75379 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra VAMP4 O75379 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra VAMP4 O75379 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra VAMP4 O75379 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra VAMP4 O75379 EVI2B Homo sapiens P34910-2
Validated Y2H
32296183
Intra VAMP4 O75379 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra VAMP4 O75379 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra VAMP4 O75379 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra VAMP4 O75379 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra VAMP4 O75379 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra VAMP4 O75379 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra VAMP4 O75379 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra VAMP4 O75379 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra VAMP4 O75379 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra VAMP4 O75379 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra VAMP4 O75379 STX6 Homo sapiens O43752
Anti Tag CoIP
25419848
Intra VAMP4 O75379 STX6 Homo sapiens O43752
Anti Tag CoIP
19557002
Intra VAMP4 O75379 STX6 Homo sapiens O43752
Anti Tag CoIP
33961781
Intra VAMP4 O75379 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 SEC11C Homo sapiens Q9BY50
Validated Y2H
32296183
Intra VAMP4 O75379 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra VAMP4 O75379 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra VAMP4 O75379 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra VAMP4 O75379 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra VAMP4 O75379 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra VAMP4 O75379 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra VAMP4 O75379 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra VAMP4 O75379 TMEM205 Homo sapiens Q6UW68
Validated Y2H
32296183
Intra VAMP4 O75379 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra VAMP4 O75379 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra VAMP4 O75379 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra VAMP4 O75379 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra VAMP4 O75379 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra VAMP4 O75379 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra VAMP4 O75379 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 ANKS6 Homo sapiens Q68DC2
Validated Y2H
32296183
Intra VAMP4 O75379 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra VAMP4 O75379 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra VAMP4 O75379 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra VAMP4 O75379 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra VAMP4 O75379 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra VAMP4 O75379 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra VAMP4 O75379 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 STX4 Homo sapiens Q12846
Anti Tag CoIP
33961781
Intra VAMP4 O75379 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra VAMP4 O75379 STX4 Homo sapiens Q12846
Y2H Array
25416956
Intra VAMP4 O75379 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra VAMP4 O75379 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra VAMP4 O75379 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra VAMP4 O75379 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra VAMP4 O75379 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra VAMP4 O75379 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra VAMP4 O75379 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Intra VAMP4 O75379 SYT2 Homo sapiens Q8N9I0
Validated Y2H
32296183
Intra VAMP4 O75379 STX16 Homo sapiens O14662-5
Y2H Array
32296183
Intra VAMP4 O75379 STX16 Homo sapiens O14662-5
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Foodborne Botulism

Botulism

Botulism Poisoning

Intoxication With Clostridium Botulinum Toxin

Wound Botulism

Food Poisoning Due To Clostridium Botulinum

Infection Due To Clostridium Botulinum

Infant Botulism

Intoxication Botulism

Botulism, Infantile

Clostridium Botulinum Poisoning

Botulism Nos
Infant Botulism

Infant Intestinal Botulism

Infant Intestinal Toxemia Botulism

Infant Intestinal Toxin-Mediated Botulism

Infantile Botulism

Botulism, Infantile
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a
Wound Botulism

Cutaneous Infectious Botulism

Cutaneous Toxin-Mediated Botulism

Inoculation Botulism

Skin Infectious Botulism

Skin Toxin-Mediated Botulism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15596 VAMP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus VAMP4 VGNC VGNC:107961
Bos taurus VAMP4 VGNC VGNC:36758
Rattus norvegicus VAMP4 RGD RGD:1309753
Mus musculus VAMP4 MGD MGI:1858730
Canis familiaris VAMP4 VGNC VGNC:48224
Macaca mulatta VAMP4 VGNC VGNC:78752
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