2. Gene
  3. STX16 - syntaxin 16 Gene

STX16 - syntaxin 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：突触 16

种属: Homo sapiens

同用名: SYN16; SYN-16

基因 ID: 8675 | 基因类型: protein coding

关于 STX16

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,651,283-58,679,526 (from NCBI)

This gene has 20 transcripts (splice variants), 202 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 25.9), lymph node (RPKM 25.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是突触融合蛋白或 t-SNARE (目标 SNAP 受体) 家族的成员。这些蛋白质存在于细胞膜上，并作为 V-SNARES (囊泡-SNAP 受体) 的靶标，允许特定的突触囊泡对接和融合。该基因所在的 20 号染色体区域的微缺失与 Ib 型假性甲状旁腺功能减退症有关。已发现该基因的多个转录变体。该基因与邻近的下游氨基肽酶样 1 (NPEPL1) 基因之间也存在通读转录。[RefSeq 提供，2011 年 3 月]

This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

STX16 基因产物(5)

mRNA Protein Name
NM_001001433.3 NP_001001433.1 syntaxin-16 isoform a
NM_001134772.3 NP_001128244.1 syntaxin-16 isoform c
NM_001134773.3 NP_001128245.1 syntaxin-16 isoform d
NM_001204868.2 NP_001191797.1 syntaxin-16 isoform e
NM_003763.6 NP_003754.2 syntaxin-16 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SNAP receptor activity IDA
IDA: 通过直接分析推断
15215310 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18195106 GOA
enables syntaxin binding IPI
IPI: 通过物理相互作用推断
16154903 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endocytic recycling IMP
IMP: 通过突变表型推断
23677696 GOA
involved in retrograde transport, endosome to Golgi IDA
IDA: 通过直接分析推断
15215310 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: 通过突变表型推断
17389686 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
9464276 GOA
located in Golgi cisterna IDA
IDA: 通过直接分析推断
17389686 GOA
part of SNARE complex IDA
IDA: 通过直接分析推断
19620288 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9587053 GOA
located in cytosol IDA
IDA: 通过直接分析推断
9587053 GOA
colocalizes with endoplasmic reticulum IDA
IDA: 通过直接分析推断
9587053 GOA
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
9587053 GOA
located in membrane IDA
IDA: 通过直接分析推断
9587053 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16154903 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
16154903 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STX16 蛋白结构

Syntaxin

Syntaxin: Syntaxin (76 - 172)

SNARE

SNARE: SNARE domain (235 - 297)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
蛋白主名 其他名称

syntaxin-16

STX16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STX16 O14662 VAMP5 Homo sapiens O95183
Validated Y2H
25416956
种属内
STX16 O14662 VAMP5 Homo sapiens O95183
Y2H Prey Pooling
25416956
种属内
STX16 O14662 VPS45 Homo sapiens Q9NRW7
Anti Tag CoIP
35271311
种属内
STX16 O14662 MEOX2 Homo sapiens P50222
Y2H Array
25416956
种属内
STX16 O14662 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

STX16 抗体

目录号 产品名 应用 反应物种
HY-P82374 Syntaxin 16 Antibody (YA2119) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Pseudohypoparathyroidism, Type Ib

Pseudohypoparathyroidism Type 1b

PHP1B

Pseudohypoparathyroidism Ib

Pseudohypoparathyroidism Type Ib

Php Ib

Pseudohypoparathyroidism 1b
Pseudohypoparathyroidism

Familial Pseudohypoparathyroidism

Parathyroid Hormone Resistant Hypoparathyroidism

Php - [Pseudohypoparathyroidism]

Constitutional Chronic Hypocalcaemia
Pseudohypoparathyroidism, Type Ia

Albright'S Hereditary Osteodystrophy

Albright Hereditary Osteodystrophy

Pseudohypoparathyroidism Type 1a

PHP1A

Albright Hereditary Osteodystrophy With Multiple Hormone Resistance

Pseudohypoparathyroidism Ia

AHO

Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy

Pseudo-Pseudohypoparathyroidism

Pseudohypoparathyroidism Type I A

Php Ia

Pseudopseudohypoparathyroidism

Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance

Pphp

Pseudopseudo-Hypoparathyroidism

Aho-Php Syndrome Ia

Albright Hereditary Osteodystrophy-Php Syndrome Ia

Pseudohypoparathyroidism 1a

Pseudohypoparathyroidism
Pseudopseudohypoparathyroidism

PPHP

Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance

Normocalcemic Pseudohypoparathyroidism

Aho-Pphp Syndrome

Albright Hereditary Osteodystrophy-Pphp Syndrome

Pseudohypoparathyroidism
Hypothyroidism, Congenital, Nongoitrous, 1

Tsh Resistance

CHNG1

Hypothyroidism Due To Tsh Receptor Mutations

Thyrotropin Resistance

Thyroid-Stimulating Hormone

Rtsh

Hypothyroidism Due To Unresponsiveness To Thyrotropin

Congenital Nongoitrous Hypothyroidism 1

Thyroid-Stimulating Hormone, Resistance To

Hypothyroidism, Nonautoimmune

Hypothyroidism, Congenital, Due To Tsh Resistance

Hypothyroidism, Congenital, Non-Goitrous, 1

Congenital Hypothyroidism Due To Tsh Resistance

Non-Autoimmune Hypothyroidism

Thyroid-Stimulating Hormone Resistance

Hypothyroidism, Congenital, Nongoitrous, Type 1

Hypothyroidism, Congenital, Nongoitrous, 3

Thyroid Hormone Resistance Syndrome
Hyperphosphatemia
Severe Congenital Neutropenia 5

Congenital Neutropenia-Myelofibrosis-Nephromegaly Syndrome

Congenital Neutropenia-Bone Marrow Fibrosis-Nephromegaly Syndrome

Vps45 Deficiency

Scn5
Eiken Syndrome

Eiken Skeletal Dysplasia

Bone Modeling Defect Of Hands And Feet

EKNS
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a
Amyotrophic Lateral Sclerosis, Juvenile, With Dementia

Juvenile Amyotrophic Lateral Sclerosis With Dementia

Als-Dementia Complex
Acrodysostosis

Acrodysplasia

Arkless-Graham Syndrome

Maroteaux-Malamut Syndrome

Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome

Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Osseous Heteroplasia, Progressive

Progressive Osseous Heteroplasia

POH

Osteoma Cutis

Familial Ectopic Ossification

Ectopic Ossification Familial Type

Ectopic Ossification

Heterotopic Ossification

Ectopic Ossification, Familial

Cutaneous Ossification

Myositis Ossificans Progressiva

Osteodermia

Osteosis Cutis

Ossification Heterotopic

Heteroplasia, Osseous, Progressive

Fibrodysplasia Ossificans Progressiva
Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder
Phosphorus Metabolism Disease

Phosphorus Metabolism Disorders

Disorder Of Phosphorus Metabolism

Phosphorus Disorder

Phosphorus Metabolism Disorder
Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis

Hge

Human Ehrlichial Infection, Human Granulocytic Type

Human Anaplasmosis Due To Anaplasma Phagocytophilum
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Brachydactyly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13977 STX16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus STX16 RGD RGD:1309423
Bos taurus STX16 VGNC VGNC:110067
Mus musculus STX16 MGD MGI:1923396
Felis catus STX16 VGNC VGNC:110159
Canis familiaris STX16 VGNC VGNC:110099
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