SNAP23 - synaptosome associated protein 23 Gene

中文名称：突触体相关蛋白 23

种属: Homo sapiens

同用名: SNAP-23; SNAP23A; SNAP23B; HsT17016

基因 ID: 8773 | 基因类型: protein coding

关于 SNAP23

Cytogenetic location: 15q15.1-q15.2 Genomic coordinates (GRCh38): 15:42,491,129-42,533,058 (from NCBI)

This gene has 23 transcripts (splice variants), 228 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 25.6), appendix (RPKM 23.5) and 25 other tissues.

功能概要

囊泡运输的特异性在一定程度上受到称为突触小蛋白/VAMP 的囊泡相关膜蛋白与称为突触融合蛋白的靶区室膜蛋白相互作用的调节。这些蛋白质与 SNAP25 (25 kDa 的突触体相关蛋白) 一起形成一个复合物，作为一般膜融合机制的结合位点。 Synaptobrevin/VAMP 和 syntaxin 被认为参与大多数 (如果不是所有) 细胞的囊泡转运，而 SNAP25 几乎只存在于大脑中，这表明存在普遍表达的 SNAP25 同系物以促进其他细胞中的转运囊泡/靶膜融合纸巾。该基因编码的蛋白质在结构和功能上与 SNAP25 相似，并与多种突触融合蛋白和突触小蛋白/VAMP 紧密结合。它是一般膜融合机制的高亲和力受体的重要组成部分，是运输囊泡对接和融合的重要调节剂。已经为该基因描述了编码不同蛋白质同种型的两种替代转录物变体。[RefSeq 提供，2008 年 7 月]

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

SNAP23 基因产物(2)

mRNA	Protein	Name
NM_003825.4	NP_003816.2	synaptosomal-associated protein 23 isoform SNAP23A
NM_130798.3	NP_570710.1	synaptosomal-associated protein 23 isoform SNAP23B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12773094	GOA
enables syntaxin binding	IPI IPI: 通过物理相互作用推断	16677249	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in histamine secretion by mast cell	IMP IMP: 通过突变表型推断	18253931	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SNARE complex	IDA IDA: 通过直接分析推断	18253931	GOA
located in adherens junction	IDA IDA: 通过直接分析推断	25468996	GOA
located in azurophil granule	IDA IDA: 通过直接分析推断	18588921	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18457912	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	26733245	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18253931	GOA
located in specific granule	IDA IDA: 通过直接分析推断	18588921	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNAP23 蛋白结构

SNAP-25

SNARE

0
100
211 a.a.

蛋白主名

其他名称

synaptosomal-associated protein 23

synaptosomal-associated protein, 23kD

SNAP23 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SNAP23	O00161	NAPB	Homo sapiens	Q9H115	Y2H Prey Pooling	25416956
Intra	SNAP23	O00161	NAPB	Homo sapiens	Q9H115	Y2H Array	25416956
Intra	SNAP23	O00161	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	SNAP23	O00161	STX11	Homo sapiens	O75558	Y2H	21900206
Intra	SNAP23	O00161	STX11	Homo sapiens	O75558	Validated Y2H	32296183
Intra	SNAP23	O00161	SCGN	Homo sapiens	O76038	Y2H Pooling	16189514
Intra	SNAP23	O00161	NAPA	Homo sapiens	P54920	Y2H Pooling	16189514

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Tetanus

Lockjaw	Clostridial Tetanus
Infection Due To Clostridium Tetani	Lock-Jaw

Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome

Cednik Syndrome	CEDNIK
Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome	Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro
Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome	Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma	Neurocutaneous Syndromes

Familial Hemophagocytic Lymphohistiocytosis 5

Fhl5	Hlh5
Hplh5	Lymphohistiocytosis, Hemophagocytic, Familial, Type 5

Lesion Of Sciatic Nerve

Nerve Lesion Sciatic

Sciatic Neuropathy

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13473	SNAP23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SNAP23	VGNC	VGNC:65515
Rattus norvegicus	SNAP23	RGD	RGD:620221
Macaca mulatta	SNAP23	VGNC	VGNC:77662
Mus musculus	SNAP23	MGD	MGI:109356
Canis familiaris	SNAP23	VGNC	VGNC:46587
Bos taurus	SNAP23	VGNC	VGNC:35050
Others	SNAP23	NCBI

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