2. Gene
  3. AGPAT4 - 1-acylglycerol-3-phosphate O-acyltransferase 4 Gene

AGPAT4 - 1-acylglycerol-3-phosphate O-acyltransferase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：1-酰基甘油-3-磷酸 O-酰基转移酶 4

种属: Homo sapiens

同用名: LPAAT4; LPLAT4; 1-AGPAT4; dJ473J16.2; LPAAT-delta

基因 ID: 56895 | 基因类型: protein coding

关于 AGPAT4

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:161,129,967-161,274,061 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 4 paralogues. Broad expression in brain (RPKM 9.7), placenta (RPKM 3.7) and 18 other tissues.

功能概要

该基因编码 1-acylglycerol-3-phosphate O-acyltransferase 家族的成员。这种完整的膜蛋白将溶血磷脂酸转化为磷脂酸，这是磷脂从头生物合成的第二步。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]

AGPAT4 基因产物(1)

mRNA Protein Name
NM_020133.3 NP_064518.1 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGPAT4 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (87 - 230)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
蛋白主名 其他名称

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1-AGP acyltransferase 4

AGPAT4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AGPAT4 Q9NRZ5 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FCGR2A Homo sapiens P12318-2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 FCGR2A Homo sapiens P12318-2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP12B Homo sapiens A6NM10-2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 AQP12B Homo sapiens A6NM10-2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FCRL3 Homo sapiens Q96P31-6
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FCRL3 Homo sapiens Q96P31-6
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra AGPAT4 Q9NRZ5 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra AGPAT4 Q9NRZ5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra AGPAT4 Q9NRZ5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fetal Akinesia Deformation Sequence 4

FADS4

Fetal Akinesia Deformation Sequence Syndrome 4

Akinesia, Fetal, Deformation Sequence, Type 4
Complete Generalized Lipodystrophy
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00459 AGPAT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus AGPAT4 VGNC VGNC:59687
Canis familiaris AGPAT4 VGNC VGNC:37713
Bos taurus AGPAT4 VGNC VGNC:25737
Macaca mulatta AGPAT4 VGNC VGNC:69654
Mus musculus AGPAT4 MGD MGI:1915512
Rattus norvegicus AGPAT4 RGD RGD:619916
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