SPACA1 - sperm acrosome associated 1 Gene

中文名称：精子顶体相关 1

种属: Homo sapiens

同用名: SAMP32

关于 SPACA1

功能概要

抗精子抗体与不明原因不孕症病例的相关性暗示了这些抗体在阻断受精方面的作用。改进免疫性不孕症的诊断和治疗，以及用于靶向避孕的蛋白质鉴定，都取决于相关精子抗原的鉴定和表征。该基因表达的蛋白质被不育男性的抗精子抗体识别。此外，针对重组蛋白产生的抗体会阻断体外受精。这种蛋白质定位于精子细胞和成熟精子的顶体膜，据认为它分别在顶体形态发生和精卵结合和融合中发挥作用。[RefSeq 提供，2008 年 7 月]

The correlation of anti-sperm Antibodies with cases of unexplained infertility implicates a role for these Antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm Antibodies from infertile males. Furthermore, Antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]