CACNG1 - calcium voltage-gated channel auxiliary subunit gamma 1 Gene

中文名称：钙电压门控通道辅助亚基γ1

种属: Homo sapiens

同用名: CACNLG

基因 ID: 786 | 基因类型: protein coding

关于 CACNG1

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:67,044,554-67,056,797 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues and 1 paralogue. Biased expression in esophagus (RPKM 1.9), prostate (RPKM 1.8) and 2 other tissues.

功能概要

电压依赖性钙通道由五个亚基组成。由该基因编码的蛋白质代表这些亚基之一，γ，并且是两种已知的γ亚基蛋白之一。这种特殊的 γ 亚基是骨骼肌 1,4-二氢吡啶敏感钙通道的一部分，是一种在兴奋-收缩偶联中起作用的完整膜蛋白。该基因是 PMP-22/EMP/MP20 家族功能多样的八成员蛋白质亚家族的一部分，位于具有两个家族成员的簇中，这两个家族成员充当跨膜 AMPA 受体调节蛋白 (TARP) 。[RefSeq 提供，2010 年 12 月]

Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA Receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]

CACNG1 基因产物(1)

mRNA	Protein	Name
NM_000727.4	NP_000718.1	voltage-dependent calcium channel gamma-1 subunit

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CACNG1 蛋白结构

Claudin_2

0
100
200
222 a.a.

蛋白主名

其他名称

voltage-dependent calcium channel gamma-1 subunit

L-type calcium channel gamma polypeptide

CACNG1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CACNG1	Q06432	VAPA	Homo sapiens	Q9P0L0	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	CACNG1	Q06432	VAPA	Homo sapiens	Q9P0L0	Y2H Array	32296183
Intra	CACNG1	Q06432	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CACNG1	Q06432	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CACNG1	Q06432	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	CACNG1	Q06432	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	CACNG1	Q06432	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
Intra	CACNG1	Q06432	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	ODF4	Homo sapiens	Q2M2E3	Validated Y2H	32296183
Intra	CACNG1	Q06432	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	CACNG1	Q06432	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	CACNG1	Q06432	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	CACNG1	Q06432	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	CACNG1	Q06432	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	CACNG1	Q06432	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	CACNG1	Q06432	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	CACNG1	Q06432	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	CACNG1	Q06432	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	CACNG1	Q06432	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	CACNG1	Q06432	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	CACNG1	Q06432	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	CACNG1	Q06432	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	CACNG1	Q06432	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	CACNG1	Q06432	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	CACNG1	Q06432	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	CACNG1	Q06432	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	CACNG1	Q06432	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	CACNG1	Q06432	GAD2	Homo sapiens	Q05329	Y2H Prey Pooling	32296183
Intra	CACNG1	Q06432	GAD2	Homo sapiens	Q05329	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Malignant Hyperthermia

Anesthesia Related Hyperthermia	Malignant Hyperpyrexia Due To Anesthesia
Hyperpyrexia, Malignant	Hyperthermia, Malignant
Malignant Hyperpyrexia	Mhs
Malignant Fever

Autosomal Dominant Nonsyndromic Deafness 78

Dfna78

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Cenani-Lenz Syndactyly Syndrome

Syndactyly Type 7	Cenani Syndactylism
Cenani-Lenz Syndactyly	CLSS
Syndactyly Cenani Lenz Type	Cenani-Lenz Syndrome
Syndactyly, Type Vii	Cenani-Lenz Type Syndactyly
Cenani Syndactyly	Syndactyly Type Vii

Hypokalemic Periodic Paralysis, Type 1

Hypokalemic Periodic Paralysis	Hokpp
Hypopp	Westphall Disease
HOKPP1	Familial Hypokalemic Periodic Paralysis
Familial Periodic Paralysis	Westphal Disease
Hypokalemic Periodic Paralysis Type 1	Hypokalemic Familial Periodic Paralysis
Periodic Hypokalemic Paralysis	Periodic Paralysis I
Hypokpp	Primary Hypokalemic Periodic Paralysis
Periodic Paralysis Hypokalemic 1	Paralysis, Hypokalemic, Periodic
Paralysis, Hypokalemic, Periodic, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01809	CACNG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CACNG1	VGNC	VGNC:26686
Rattus norvegicus	CACNG1	RGD	RGD:2249
Canis familiaris	CACNG1	VGNC	VGNC:38647
Mus musculus	CACNG1	MGD	MGI:1206582
Felis catus	CACNG1	VGNC	VGNC:98775
Macaca mulatta	CACNG1	VGNC	VGNC:82117

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CACNG1 - calcium voltage-gated channel auxiliary subunit gamma 1 Gene

关于 CACNG1

功能概要

CACNG1 基因产物(1)

CACNG1 蛋白结构

CACNG1 蛋白互作信息

关联疾病

直系同源

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CACNG1 - calcium voltage-gated channel auxiliary subunit gamma 1 Gene

关于 CACNG1

功能概要

CACNG1 基因产物(1)

CACNG1 蛋白结构

CACNG1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z