LAPTM4A - lysosomal protein transmembrane 4 alpha Gene

中文名称：溶酶体蛋白跨膜 4 α

种属: Homo sapiens

同用名: MBNT; Mtrp; LAPTM4; HUMORF13

基因 ID: 9741 | 基因类型: protein coding

关于 LAPTM4A

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,032,650-20,051,628 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 245.2), testis (RPKM 209.5) and 25 other tissues.

功能概要

该基因编码的蛋白质具有四个预测的跨膜结构域。该基因的功能尚未确定；然而，对小鼠同系物的研究表明，它在小分子跨内体和溶酶体膜的转运中起作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

LAPTM4A 基因产物(1)

mRNA	Protein	Name
NM_014713.5	NP_055528.1	lysosomal-associated transmembrane protein 4A

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21224396	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	10942595	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	22096579	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	22096579	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LAPTM4A 蛋白结构

Mtp

0
100
200
233 a.a.

蛋白主名

其他名称

lysosomal-associated transmembrane protein 4A

golgi 4-transmembrane-spanning transporter MTP

LAPTM4A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	LAPTM4A	Q15012	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	LAPTM4A	Q15012	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	LAPTM4A	Q15012	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	LAPTM4A	Q15012	TMED8	Homo sapiens	Q6PL24	Y2H Prey Pooling	32296183
Intra	LAPTM4A	Q15012	TMED8	Homo sapiens	Q6PL24	Validated Y2H	32296183
Intra	LAPTM4A	Q15012	TMED8	Homo sapiens	Q6PL24	Y2H Array	32296183
Intra	LAPTM4A	Q15012	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	LAPTM4A	Q15012	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	LAPTM4A	Q15012	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	LAPTM4A	Q15012	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	LAPTM4A	Q15012	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	LAPTM4A	Q15012	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32814053
Intra	LAPTM4A	Q15012	EEF1D	Homo sapiens	P29692-2	Y2H Array	32814053
Intra	LAPTM4A	Q15012	EEF1D	Homo sapiens	P29692-2	Y2H Pooling	32814053
Intra	LAPTM4A	Q15012	UQCRB	Homo sapiens	P14927	Y2H Array	32814053
Intra	LAPTM4A	Q15012	UQCRB	Homo sapiens	P14927	Y2H Pooling	32814053
Intra	LAPTM4A	Q15012	UQCRB	Homo sapiens	P14927	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myofascial Pain Syndrome

Myofascial Pain Syndromes	Myofascial Pain Dysfunction Syndrome
Fibromyalgia

Patellofemoral Pain Syndrome

Plantar Fasciitis

Fasciitis, Plantar

Facial Neuralgia

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Frozen Shoulder

Adhesive Capsulitis Of Shoulder	Bursitis
Adhesions-Capsulitis,Shoulder	Pericapsulitis Of Shoulder
Duplay Bursitis	Adhesive Shoulder Peritendinitis
Subscapular Adhesion	Shoulder Adhesion
Adhesive Enthesopathy Of Shoulder Region	Adhesive Peritendinitis
Adhesive Shoulder Tenosynovitis	Duplay Periarthritis
Adhesive Shoulder Tendinitis

Epicondylitis

Tennis Elbow	Lateral Epicondylitis
Golfer'S Elbow	Medial Epicondylitis
Andrel Epicondylitis	Archer'S Elbow
Hockey Elbow	Shooter'S Elbow

Heel Spur

Calcaneal Spur

Bursitis

Bursitis, Not Otherwise Specified

Inflammation Of Bursa

Urethral Syndrome

Urethral Disease	Urethral Diseases
Urethra Disease	Abnormality Of The Urethra
Urethral Disorders

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Spondylosis

Lumbar Spondylosis With Myelopathy	Lumbosacral Spondylosis Without Myelopathy
Spondylogenic Compression Of Lumbar Spinal Cord	Spondylogenic Compression Of Thoracic Spinal Cord
Spondylosis With Myelopathy	Thoracic Or Lumbar Spondylosis With Myelopathy

Radiculopathy

Pinched Nerve	Nerve Root Disorder
Radiculopathy, Site Unspecified	Radicular Neuropathy
Radicular Syndrome	Radicular Pain
Radiculitis	Radiculitis Nos
Spinal Root Pain	Nerve Root Neuritis
Radiculopathy In Spondylosis

De Quervain Disease

Radial Styloid Tenosynovitis	Tenosynovitis, De Quervain'S
De Quervain'S Disease	Tenosynovitis Of Radial Styloid Process
Stenosans Tenosynovitis

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07521	LAPTM4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	LAPTM4A	VGNC	VGNC:42583
Mus musculus	LAPTM4A	MGD	MGI:108017
Rattus norvegicus	LAPTM4A	RGD	RGD:735179
Macaca mulatta	LAPTM4A	VGNC	VGNC:74272
Bos taurus	LAPTM4A	VGNC	VGNC:30787

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