GUCA2A - guanylate cyclase activator 2A Gene

中文名称：鸟苷酸环化酶激活因子 2A

种属: Homo sapiens

同用名: GUCA2; STARA; GCAP-I

基因 ID: 2980 | 基因类型: protein coding

关于 GUCA2A

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,162,690-42,164,745 (from NCBI)

This gene has 1 transcript (splice variant), 143 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 352.1), colon (RPKM 198.7) and 1 other tissue.

功能概要

预测启用鸟苷酸环化酶激活剂活性。预计参与鸟苷酸环化酶活性和信号转导的正向调节。预测位于细胞外区域。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Guanylate Cyclase Activator activity. Predicted to be involved in positive regulation of Guanylate Cyclase activity and signal transduction. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

GUCA2A 基因产物(1)

mRNA	Protein	Name
NM_033553.3	NP_291031.2	guanylin precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GUCA2A 蛋白结构

Guanylin

0
100
115 a.a.

蛋白主名

其他名称

guanylin

guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable)

GUCA2A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GUCA2A	Q02747	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
种属内	GUCA2A	Q02747	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
种属内	GUCA2A	Q02747	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
种属内	GUCA2A	Q02747	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
种属内	GUCA2A	Q02747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
种属内	GUCA2A	Q02747	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
种属内	GUCA2A	Q02747	SLC34A2	Homo sapiens	O95436-2	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	SLC34A2	Homo sapiens	O95436-2	Y2H Array	32296183
种属内	GUCA2A	Q02747	GJA8	Homo sapiens	P48165	Y2H Array	32296183
种属内	GUCA2A	Q02747	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	TRAM1	Homo sapiens	Q15629	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	TRAM1	Homo sapiens	Q15629	Validated Y2H	32296183
种属内	GUCA2A	Q02747	TRAM1	Homo sapiens	Q15629	Y2H Array	32296183
种属内	GUCA2A	Q02747	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
种属内	GUCA2A	Q02747	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
种属内	GUCA2A	Q02747	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
种属内	GUCA2A	Q02747	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	SGTA	Homo sapiens	O43765	Y2H Array	32296183
种属内	GUCA2A	Q02747	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
种属内	GUCA2A	Q02747	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
种属内	GUCA2A	Q02747	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
种属内	GUCA2A	Q02747	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	GUCA2A	Q02747	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
种属内	GUCA2A	Q02747	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Large Intestine Adenoma

Adenoma Of Large Intestine

Secretory Diarrhea

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Anismus

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Osmotic Diarrhea

Acromesomelic Dysplasia

Acromesomelic Dwarfism	Dysplasia, Acromesomelic
Acromesomelic Dysplasia Hunter-Thompson Type

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Leber Congenital Amaurosis 1

LCA1	Amaurosis Congenita Of Leber I
Lca	Retinal Blindness, Congenital
Crb	Leber Congenital Amaurosis Type I
Leber Congenital Amaurosis, Type 1	Amaurosis Congenita Of Leber, Type 1

Constipation

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05916	GUCA2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GUCA2A	VGNC	VGNC:29716
Mus musculus	GUCA2A	MGD	MGI:102738
Macaca mulatta	GUCA2A	VGNC	VGNC:73325
Canis familiaris	GUCA2A	VGNC	VGNC:41564
Felis catus	GUCA2A	VGNC	VGNC:67512
Rattus norvegicus	GUCA2A	RGD	RGD:2766

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