1. Gene
  2. TRAM1 - translocation associated membrane protein 1 Gene

TRAM1 - translocation associated membrane protein 1 Gene

中文名称:易位相关膜蛋白 1

种属: Homo sapiens

同用名: TRAM; PNAS8; TRAMP

基因 ID: 23471 | 基因类型: protein coding

关于 TRAM1

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,573,218-70,608,416 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues.

功能概要

该基因编码一种多通道膜蛋白,它是哺乳动物内质网的一部分。编码的蛋白质影响糖基化,并通过调节在易位暂停期间胞质溶胶可见的新生多肽链的哪些结构域来促进分泌蛋白跨内质网膜的易位。[RefSeq 提供,2009 年 10 月]

This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

TRAM1 基因产物(3)

mRNA Protein Name
NM_001317804.2 NP_001304733.1 translocating chain-associated membrane protein 1 isoform 2
NM_001317805.2 NP_001304734.1 translocating chain-associated membrane protein 1 isoform 3
NM_014294.6 NP_055109.1 translocating chain-associated membrane protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18555783 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cotranslational protein targeting to membrane IDA
IDA: 通过直接分析推断
8616892 GOA
involved in protein insertion into ER membrane IDA
IDA: 通过直接分析推断
8616892 GOA
involved in response to unfolded protein IMP
IMP: 通过突变表型推断
20430023 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
18555783 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
8616892 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRAM1 蛋白结构

TRAM1

TRAM1: TRAM1-like protein (48 - 116)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (118 - 316)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

translocating chain-associated membrane protein 1

translocating chain-associating membrane protein

TRAM1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRAM1 Q15629 BCAP31 Homo sapiens P51572
Ub Reconstruction
18555783
Intra TRAM1 Q15629 BCAP31 Homo sapiens P51572
Anti Bait CoIP
18555783
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meckel Syndrome, Type 2

MKS2

Meckel Syndrome 2

Meckel-Gruber Syndrome, Type 2

Meckel Syndrome Type 2

Oropouche Fever

Oropouche Virus Disease

Oropouche Mosquito-Borne Viral Fever

Ceroid Lipofuscinosis, Neuronal, 8, Northern Epilepsy Variant

Northern Epilepsy

Neuronal Ceroid Lipofuscinosis 8 Northern Epilepsy Variant

Epmr

Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type

Northern Epilepsy Syndrome

Epilepsy, Progressive, With Mental Retardation

Northern Epilepsy Variant, Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

Progressive Epilepsy With Mental Retardation, Northern Epilepsy

Cln8 Disease, Northern Epilepsy Variant

Ncl, Northern Epilepsy Variant

Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

CLN8NE

Ceroid Lipofuscinosis, Neuronal, 8

Orofaciodigital Syndrome Vi

OFD6

Varadi-Papp Syndrome

Varadi Syndrome

Joubert Syndrome With Orofaciodigital Defect

Orofaciodigital Syndrome Type 6

Orofaciodigital Syndrome 6

Oral-Facial-Digital Syndrome, Type Vi

Ofds Vi

Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation

Polydactyly Cleft Lip Palate Psychomotor Retardation

Oral-Facial-Digital Syndrome Type 6

Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome

Polydactyly - Cleft Lip/Palate - Psychomotor Retardation

Váradi Syndrome

Váradi-Papp Syndrome

Joubert Syndrome With Oral-Facial-Digital Syndrome

Oral-Facial-Digital Syndrome 6

Joubert-Orofaciodigital Syndrome

Orofaciodigital Syndrome, Type Vi

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TRAM1 VGNC VGNC:81678
Canis familiaris TRAM1 VGNC VGNC:54123
Macaca mulatta TRAM1 VGNC VGNC:84131
Bos taurus TRAM1 VGNC VGNC:53882
Mus musculus TRAM1 MGD MGI:1919515
Rattus norvegicus TRAM1 RGD RGD:1359100