GHITM - growth hormone inducible transmembrane protein Gene

中文名称：生长激素诱导跨膜蛋白

种属: Homo sapiens

同用名: DERP2; MICS1; My021; PTD010; TMBIM5; HSPC282

基因 ID: 27069 | 基因类型: protein coding

关于 GHITM

Cytogenetic location: 10q23.1 Genomic coordinates (GRCh38): 10:84,139,509-84,153,568 (from NCBI)

This gene has 13 transcripts (splice variants), 230 orthologues and 5 paralogues. Ubiquitous expression in heart (RPKM 139.5), kidney (RPKM 133.1) and 25 other tissues.

功能概要

参与线粒体内膜组织和线粒体细胞色素 c 释放的负调节。位于线粒体中。是线粒体内膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Involved in inner mitochondrial membrane organization and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

GHITM 基因产物(1)

mRNA	Protein	Name
NM_014394.3	NP_055209.2	growth hormone-inducible transmembrane protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium:proton antiporter activity	IMP IMP: 通过突变表型推断	36321428	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21903422	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcium export from the mitochondrion	IMP IMP: 通过突变表型推断	35912435	GOA
involved in calcium ion transport	IMP IMP: 通过突变表型推断	36321428	GOA
involved in inner mitochondrial membrane organization	IMP IMP: 通过突变表型推断	18417609	GOA
involved in mitochondrial calcium ion transmembrane transport	IMP IMP: 通过突变表型推断	35912435	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IMP IMP: 通过突变表型推断	18417609	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	18417609	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GHITM 蛋白结构

BaxI_1

Bax1-I

0
100
200
300
345 a.a.

蛋白主名

其他名称

growth hormone-inducible transmembrane protein

dermal papilla-derived protein 2

GHITM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	GHITM	Q9H3K2	TMEM242	Homo sapiens	Q9NWH2	Y2H Array	32296183
Intra	GHITM	Q9H3K2	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	GHITM	Q9H3K2	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	GHITM	Q9H3K2	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	GHITM	Q9H3K2	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	GHITM	Q9H3K2	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	GHITM	Q9H3K2	JSRP1	Homo sapiens	Q96MG2	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	JSRP1	Homo sapiens	Q96MG2	Y2H Array	32296183
Intra	GHITM	Q9H3K2	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	GHITM	Q9H3K2	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	GHITM	Q9H3K2	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Cross	GHITM	Q9H3K2	orf9c_sars2	SARS-CoV-2	P0DTD3	Y2H Array	36217030
Intra	GHITM	Q9H3K2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	GHITM	Q9H3K2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	GHITM	Q9H3K2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Persistent Moderate Asthma

Persistent Mild Asthma

Inflammatory Bowel Disease 20

IBD20

Celery Allergy

Pollen Allergy

Hay Fever

Vegetable Allergy

Shrimp Allergy

Crustacean Allergy

Nasal Cavity Disease

Disorder Of Nasal Cavity

Respiratory Allergy

Airway Allergy

Thunderstorm Triggered Asthma

Thunderstorm Asthma

Thunderstorm Related Asthma

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Apple Allergy

Malus Domestica Fruit Allergy

Wheat Allergy

Wheat Allergic Reaction	Wheat Hypersensitivity
Allergy To Wheat	Allergy Wheat

Chronic Rhinitis

Rhinitis - Chronic	Chronic Rhinitis Nos
Rhinitis	Rhinitis Nos

Latex Allergy

Fruit Allergy

Allergy To Fruit

Legume Allergy

Fabaceae Allergy

Chronic Asthma

Peanut Allergy

Allergy To Peanuts	Peanut Allergic Reaction
Allergies Peanut	Peanut Hypersensitivity

Egg Allergy

Allergy To Eggs	Allergies Egg
Egg Hypersensitivity

Occupational Asthma

Environmental Induced Asthma

Irritant Asthma

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05411	GHITM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	GHITM	VGNC	VGNC:41205
Macaca mulatta	GHITM	VGNC	VGNC:72735
Bos taurus	GHITM	VGNC	VGNC:29348
Rattus norvegicus	GHITM	RGD	RGD:1359301
Mus musculus	GHITM	MGD	MGI:1913342
Felis catus	GHITM	VGNC	VGNC:62543

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