2. Gene
  3. TECR - trans-2,3-enoyl-CoA reductase Gene

TECR - trans-2,3-enoyl-CoA reductase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：反式 2,3-烯酰辅酶 A 还原酶

种属: Homo sapiens

同用名: SC2; TER; GPSN2; MRT14

基因 ID: 9524 | 基因类型: protein coding

关于 TECR

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,527,726-14,565,980 (from NCBI)

This gene has 26 transcripts (splice variants), 268 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 95.3), skin (RPKM 93.5) and 25 other tissues.

功能概要

该基因编码位于内质网中的多通道膜蛋白，属于类固醇 5-α 还原酶家族。微粒体长链和超长链脂肪酸的延长由 4 个连续反应组成。该蛋白质催化最后一步，将反式 2,3-烯酰辅酶 A 还原为饱和酰基辅酶 A。已发现该基因的可变剪接转录本变体。[RefSeq 提供，2011 年 4 月]

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

TECR 基因产物(2)

mRNA Protein Name
NM_001321170.1 NP_001308099.1 very-long-chain enoyl-CoA reductase isoform 2
NM_138501.6 NP_612510.1 very-long-chain enoyl-CoA reductase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables very-long-chain enoyl-CoA reductase activity IDA
IDA: 通过直接分析推断
12482854 GOA
enables very-long-chain enoyl-CoA reductase activity IMP
IMP: 通过突变表型推断
24220030 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid elongation IDA
IDA: 通过直接分析推断
12482854 GOA
involved in sphingolipid metabolic process IMP
IMP: 通过突变表型推断
25049234 GOA
involved in very long-chain fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
12482854 GOA
involved in very long-chain fatty acid biosynthetic process IMP
IMP: 通过突变表型推断
24220030 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24220030 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
12482854 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TECR 蛋白结构

Steroid_dh

Steroid_dh: 3-oxo-5-alpha-steroid 4-dehydrogenase (155 - 308)

  • 0
  • 100
  • 200
  • 308 a.a.
蛋白主名 其他名称

very-long-chain enoyl-CoA reductase

epididymis secretory sperm binding protein

TECR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TECR Q9NZ01 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra TECR Q9NZ01 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra TECR Q9NZ01 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 TFAM Homo sapiens Q00059
Y2H Array
32296183
Intra TECR Q9NZ01 TFAM Homo sapiens Q00059
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra TECR Q9NZ01 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra TECR Q9NZ01 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra TECR Q9NZ01 HACD1 Homo sapiens B0YJ81
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 HACD1 Homo sapiens B0YJ81
Y2H Array
32296183
Intra TECR Q9NZ01 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 STOM Homo sapiens P27105
Y2H Array
32296183
Intra TECR Q9NZ01 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra TECR Q9NZ01 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra TECR Q9NZ01 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra TECR Q9NZ01 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra TECR Q9NZ01 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra TECR Q9NZ01 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 CLDN5 Homo sapiens O00501
Y2H Array
32296183
Intra TECR Q9NZ01 CLDN5 Homo sapiens O00501
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra TECR Q9NZ01 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra TECR Q9NZ01 STING1 Homo sapiens Q86WV6
Y2H Array
32296183
Intra TECR Q9NZ01 STING1 Homo sapiens Q86WV6
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra TECR Q9NZ01 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra TECR Q9NZ01 HACD2 Homo sapiens Q6Y1H2
Crosslink
30021884
Intra TECR Q9NZ01 HACD2 Homo sapiens Q6Y1H2
Y2H Prey Pooling
25416956
Intra TECR Q9NZ01 HACD2 Homo sapiens Q6Y1H2
Y2H Array
25416956
Intra TECR Q9NZ01 HACD2 Homo sapiens Q6Y1H2
Validated Y2H
25416956
Intra TECR Q9NZ01 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra TECR Q9NZ01 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra TECR Q9NZ01 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra TECR Q9NZ01 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra TECR Q9NZ01 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra TECR Q9NZ01 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Recessive 14

MRT14

Mental Retardation, Autosomal Recessive 14

Autosomal Recessive Intellectual Developmental Disorder 14

Mental Retardation, Autosomal Recessive, Type 14
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Seborrheic Infantile Dermatitis

Cradle Cap

Infantile Seborrhoeic Dermatitis

Seborrhoea Capitis

Seborrhoeic Dermatitis Of Scalp

Seborrhoeic Eczema Of Scalp

Complement 5 Dysfunction

Generalized Seborrheic Dermatitis Of Infants

Infantile Seborrheic Dermatitis

Pityriasis Capitis

Seborrhea Capitis

Seborrhea Sicca

Dandruff

Complement Component 5 Deficiency

Seborrheic Dermatitis

Seborrheic Dermatitis Of Scalp

Scurfiness Of Scalp

Seborrheic Dermatitis Of Infancy

Infantile Seborrhoeic Eczema

Neonatal Seborrhoeic Dermatitis

Infantile Seborrhoeic Dermatitis Of The Scalp
Cataract 24

CTRCT24

Cataract 24, Anterior Polar

Cataract, Anterior Polar, 2

Ctaa2

Anterior Polar Cataract 2

Early-Onset Anterior Polar Cataract

Early-Onset Anterior Subcapsular Cataract

Anterior Polar Cataract 24

Cataract Anterior Polar

Cataract, Anterior Polar-2

Cataract, Anterior Polar
Tongue Carcinoma

Tongue Cancer

Malignant Neoplasm Of Tongue

Tongue Neoplasms

Tongue Neoplasm
Oral Mucosa Leukoplakia

Leukoplakia, Oral

Leukoplakia Of Buccal Mucosa
Spindle Cell Hemangioma

Sch

Spindle Cell Hemangioendothelioma
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14349 TECR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TECR VGNC VGNC:80732
Macaca mulatta TECR VGNC VGNC:103877
Canis familiaris TECR VGNC VGNC:47234
Rattus norvegicus TECR RGD RGD:620376
Bos taurus TECR VGNC VGNC:35730
Mus musculus TECR MGD MGI:1915408
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