2. Gene
  3. HACD2 - 3-hydroxyacyl-CoA dehydratase 2 Gene

HACD2 - 3-hydroxyacyl-CoA dehydratase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：3-羟基酰基辅酶 A 脱水酶 2

种属: Homo sapiens

同用名: PTPLB

基因 ID: 201562 | 基因类型: protein coding

关于 HACD2

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,491,554-123,585,053 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 34.0), prostate (RPKM 10.4) and 24 other tissues.

功能概要

该基因编码的蛋白质可以催化长链脂肪酸转化为超长链脂肪酸的第三步 (脱水) 。编码的蛋白质定位于内质网膜。[RefSeq 提供，2016 年 7 月]

The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]

HACD2 基因产物(5)

mRNA Protein Name
NM_001329783.2 NP_001316712.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform a
NM_001329784.2 NP_001316713.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform c
NM_001329786.2 NP_001316715.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform d
NM_001329787.2 NP_001316716.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform d
NM_198402.5 NP_940684.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-hydroxyacyl-CoA dehydratase activity EXP
EXP: 通过实验结果推断
18554506 GOA
enables enzyme binding IDA
IDA: 通过直接分析推断
18554506 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15024066 GOA
NOT enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
15024066 GOA
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity IDA
IDA: 通过直接分析推断
18554506 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid elongation IDA
IDA: 通过直接分析推断
18554506 GOA
involved in sphingolipid biosynthetic process IGI
IGI: 通过遗传相互作用推断
18554506 GOA
involved in very long-chain fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
18554506 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15024066 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HACD2 蛋白结构

PTPLA

PTPLA: Protein tyrosine phosphatase-like protein, PTPLA (85 - 246)

  • 0
  • 100
  • 200
  • 254 a.a.
蛋白主名 其他名称

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b

HACD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HACD2 Q6Y1H2 IL10RA Homo sapiens Q13651
Y2H Array
32296183
Intra HACD2 Q6Y1H2 IL10RA Homo sapiens Q13651
Y2H Prey Pooling
32296183
Intra HACD2 Q6Y1H2 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra HACD2 Q6Y1H2 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra HACD2 Q6Y1H2 TECR Homo sapiens Q9NZ01
Validated Y2H
32296183
Intra HACD2 Q6Y1H2 TECR Homo sapiens Q9NZ01
Y2H Array
32296183
Intra HACD2 Q6Y1H2 TECR Homo sapiens Q9NZ01
Y2H Prey Pooling
32296183
Intra HACD2 Q6Y1H2 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra HACD2 Q6Y1H2 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra HACD2 Q6Y1H2 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra HACD2 Q6Y1H2 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra HACD2 Q6Y1H2 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra HACD2 Q6Y1H2 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra HACD2 Q6Y1H2 BCAP31 Homo sapiens P51572
Anti Tag CoIP
15024066
Intra HACD2 Q6Y1H2 BCAP31 Homo sapiens P51572
IF
15024066
Intra HACD2 Q6Y1H2 BCAP31 Homo sapiens P51572
Ub Reconstruction
15024066
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Unilateral Focal Polymicrogyria
Spinocerebellar Ataxia 34

Erythrokeratodermia With Ataxia

Spinocerebellar Ataxia Type 34

SCA34

Erythrokeratodermia - Ataxia

Giroux Barbeau Syndrome

Spinocerebellar Ataxia And Erythrokeratodermia

Erythrokeratodermia Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05985 HACD2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus HACD2 VGNC VGNC:102753
Rattus norvegicus HACD2 RGD RGD:1306337
Mus musculus HACD2 MGD MGI:1918007
Bos taurus HACD2 VGNC VGNC:50252
Macaca mulatta HACD2 VGNC VGNC:73382
Canis familiaris HACD2 VGNC VGNC:53075
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