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  3. SMPD2 - sphingomyelin phosphodiesterase 2 Gene

SMPD2 - sphingomyelin phosphodiesterase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鞘磷脂磷酸二酯酶 2

种属: Homo sapiens

同用名: ISC1; NSMASE; NSMASE1

基因 ID: 6610 | 基因类型: protein coding

关于 SMPD2

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,440,724-109,443,919 (from NCBI)

This gene has 3 transcripts (splice variants) and 203 orthologues. Broad expression in testis (RPKM 17.9), skin (RPKM 6.8) and 24 other tissues.

功能概要

该基因编码一种蛋白质，最初根据细菌鞘磷脂酶和酵母蛋白之间的序列相似性将其鉴定为鞘磷脂酶。随后的研究表明，其生物学功能不太可能是作为一种鞘磷脂酶，而是作为一种溶血磷脂酶。[RefSeq 提供，2009 年 10 月]

This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between Bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]

SMPD2 基因产物(1)

mRNA Protein Name
NM_003080.3 NP_003071.2 sphingomyelin phosphodiesterase 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphoric diester hydrolase activity IDA
IDA: 通过直接分析推断
10608884 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
enables sphingomyelin phosphodiesterase activity IDA
IDA: 通过直接分析推断
10608884 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in sphingomyelin catabolic process IDA
IDA: 通过直接分析推断
10608884 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMPD2 蛋白结构

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (14 - 272)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
蛋白主名 其他名称

sphingomyelin phosphodiesterase 2

N-SMase

SMPD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SMPD2 O60906 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra SMPD2 O60906 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra SMPD2 O60906 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra SMPD2 O60906 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra SMPD2 O60906 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra SMPD2 O60906 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra SMPD2 O60906 PITPNC1 Homo sapiens Q9UKF7-2
Validated Y2H
32296183
Intra SMPD2 O60906 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra SMPD2 O60906 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra SMPD2 O60906 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra SMPD2 O60906 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra SMPD2 O60906 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra SMPD2 O60906 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra SMPD2 O60906 ARFIP1 Homo sapiens P53367
Validated Y2H
32296183
Intra SMPD2 O60906 MTHFR Homo sapiens P42898
Anti Tag CoIP
33961781
Intra SMPD2 O60906 MTHFR Homo sapiens P42898
Anti Tag CoIP
28514442
Intra SMPD2 O60906 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra SMPD2 O60906 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra SMPD2 O60906 SLC10A1 Homo sapiens Q14973
Validated Y2H
32296183
Intra SMPD2 O60906 STAR Homo sapiens P49675
Validated Y2H
32296183
Intra SMPD2 O60906 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra SMPD2 O60906 COQ8A Homo sapiens Q8NI60
Validated Y2H
32296183
Intra SMPD2 O60906 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra SMPD2 O60906 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra SMPD2 O60906 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra SMPD2 O60906 GAD2 Homo sapiens Q05329
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Niemann-Pick Disease, Type A

Niemann-Pick Disease Type A

Sphingomyelin Lipidosis

Sphingomyelinase Deficiency

Niemann-Pick Disease, Intermediate, Protracted Neurovisceral

Acid Sphingomyelinase Deficiency, Neurovisceral Type

Asmd, Neurovisceral Type

Infantile Neurovisceral Acid Sphingomyelinase Deficiency

Infantile Neurovisceral Asmd

Npd-A

Niemann-Pick Disease A

NPDA

Classical Niemann-Pick Disease

Niemann-Pick Disease Acute Neuronopathic Form

Niemann-Pick Disease Acute Neurovisceral Form

Niemann-Pick Disease Classical Infantile Form

Niemann-Pick Disease Intermediate Protracted Neurovisceral

Niemann-Pick Disease Neuronopathic Type

Niemann-Pick Disease Type I

Npa

Niemann-Pick Diseases
Farber Lipogranulomatosis

Farber Disease

Acid Ceramidase Deficiency

Ceramidase Deficiency

Ac Deficiency

N-Laurylsphingosine Deacylase Deficiency

Farber'S Disease

FRBRL

Farber'S Lipogranulomatosis

Acylsphingosine Deacylase Deficiency

Farber-Uzman Syndrome

Acy
Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis

Niemann-Pick Diseases

Lipoid Histiocytosis

Sphingomyelin Lipidosis

Sphingomyelinase Deficiency Disease

Lipid Histiocytosis

Neuronal Cholesterol Lipidosis

Neuronal Lipidosis

Npd

Sphingomyelinase Deficiency

Niemann-Pick Disease, Type A
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13448 SMPD2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SMPD2 VGNC VGNC:65502
Mus musculus SMPD2 MGD MGI:1278330
Bos taurus SMPD2 VGNC VGNC:35030
Rattus norvegicus SMPD2 RGD RGD:619753
Macaca mulatta SMPD2 VGNC VGNC:104429
Canis familiaris SMPD2 VGNC VGNC:46570
Others SMPD2 NCBI
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