2. Gene
  3. ARFIP1 - ADP ribosylation factor interacting protein 1 Gene

ARFIP1 - ADP ribosylation factor interacting protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ADP 核糖基化因子相互作用蛋白 1

种属: Homo sapiens

同用名: HSU52521

基因 ID: 27236 | 基因类型: protein coding

关于 ARFIP1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:152,779,954-152,912,357 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 8.9), colon (RPKM 8.5) and 25 other tissues.

功能概要

启用磷脂酰肌醇 4-磷酸结合活性。参与逆行运输的负调节，内体到高尔基体。在细胞内蛋白质运输和蛋白质分泌调节的上游或内部起作用。位于高尔基体膜；胞质溶胶；和跨高尔基网络膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARFIP1 基因产物(6)

mRNA Protein Name
NM_001025593.3 NP_001020764.1 arfaptin-1 isoform 2
NM_001025595.3 NP_001020766.1 arfaptin-1 isoform 1
NM_001287431.2 NP_001274360.1 arfaptin-1 isoform 1
NM_001287432.2 NP_001274361.1 arfaptin-1 isoform 1
NM_001287433.2 NP_001274362.1 arfaptin-1 isoform 2
NM_014447.4 NP_055262.1 arfaptin-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-4-phosphate binding IDA
IDA: 通过直接分析推断
23695357 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22981988 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within intracellular protein transport IDA
IDA: 通过直接分析推断
12606037 GOA
involved in negative regulation of retrograde transport, endosome to Golgi IMP
IMP: 通过突变表型推断
25789876 GOA
acts upstream of or within regulation of protein secretion IDA
IDA: 通过直接分析推断
12606037 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
9038142 GOA
located in cytosol IDA
IDA: 通过直接分析推断
9038142 GOA
located in trans-Golgi network membrane IDA
IDA: 通过直接分析推断
23695357 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARFIP1 蛋白结构

Arfaptin

Arfaptin: Arfaptin-like domain (123 - 348)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

arfaptin-1

ARFIP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARFIP1 P53367 TNFRSF10D Homo sapiens Q9UBN6
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 TNFRSF10D Homo sapiens Q9UBN6
Validated Y2H
32296183
Intra ARFIP1 P53367 TNFRSF10D Homo sapiens Q9UBN6
Y2H Array
32296183
Intra ARFIP1 P53367 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 MAGEA6 Homo sapiens P43360
Validated Y2H
32296183
Intra ARFIP1 P53367 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra ARFIP1 P53367 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra ARFIP1 P53367 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra ARFIP1 P53367 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra ARFIP1 P53367 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
Intra ARFIP1 P53367 ARL1 Homo sapiens P40616
Pull Down
22981988
Intra ARFIP1 P53367 ARL1 Homo sapiens P40616
Anti Tag CoIP
35271311
Intra ARFIP1 P53367 ARL1 Homo sapiens P40616
Anti Tag CoIP
22981988
Intra ARFIP1 P53367 SYNGR3 Homo sapiens O43761
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 SYNGR3 Homo sapiens O43761
Y2H Array
32296183
Intra ARFIP1 P53367 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra ARFIP1 P53367 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra ARFIP1 P53367 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 PRKD1 Homo sapiens Q15139
Protein Kinase Assay
22981988
Intra ARFIP1 P53367 SMIM5 Homo sapiens Q71RC9
Y2H Array
32296183
Intra ARFIP1 P53367 SMIM5 Homo sapiens Q71RC9
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 SMIM5 Homo sapiens Q71RC9
Validated Y2H
32296183
Intra ARFIP1 P53367 SMPD2 Homo sapiens O60906
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 SMPD2 Homo sapiens O60906
Y2H Array
32296183
Intra ARFIP1 P53367 DESI2 Homo sapiens Q9BSY9
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 DESI2 Homo sapiens Q9BSY9
Validated Y2H
32296183
Intra ARFIP1 P53367 DESI2 Homo sapiens Q9BSY9
Y2H Array
32296183
Intra ARFIP1 P53367 AFF1 Homo sapiens P51825-3
Y2H Array
32296183
Intra ARFIP1 P53367 AFF1 Homo sapiens P51825-3
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 SFT2D1 Homo sapiens Q8WV19
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 SFT2D1 Homo sapiens Q8WV19
Validated Y2H
32296183
Intra ARFIP1 P53367 SFT2D1 Homo sapiens Q8WV19
Y2H Array
32296183
Intra ARFIP1 P53367 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra ARFIP1 P53367 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra ARFIP1 P53367 ARF1 Homo sapiens P84077
Pull Down
22981988
Intra ARFIP1 P53367 ARF1 Homo sapiens P84077
Anti Tag CoIP
22981988
Intra ARFIP1 P53367 ARFIP2 Homo sapiens P53365
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 ARFIP2 Homo sapiens P53365
Y2H Array
32296183
Intra ARFIP1 P53367 ARFIP2 Homo sapiens P53365
Anti Tag CoIP
35271311
Intra ARFIP1 P53367 BSND Homo sapiens Q8WZ55
Validated Y2H
32296183
Intra ARFIP1 P53367 BSND Homo sapiens Q8WZ55
Y2H Array
32296183
Intra ARFIP1 P53367 BSND Homo sapiens Q8WZ55
Y2H Prey Pooling
32296183
Intra ARFIP1 P53367 SCAMP1 Homo sapiens O15126
Y2H Array
32296183
Intra ARFIP1 P53367 SCAMP1 Homo sapiens O15126
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00905 ARFIP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ARFIP1 VGNC VGNC:38038
Mus musculus ARFIP1 MGD MGI:1277120
Macaca mulatta ARFIP1 VGNC VGNC:69878
Felis catus ARFIP1 VGNC VGNC:59871
Bos taurus ARFIP1 VGNC VGNC:26067
Rattus norvegicus ARFIP1 RGD RGD:708401
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