1. Gene
  2. SCAMP1 - secretory carrier membrane protein 1 Gene

SCAMP1 - secretory carrier membrane protein 1 Gene

中文名称:分泌性载体膜蛋白 1

种属: Homo sapiens

同用名: SCAMP; SCAMP37

基因 ID: 9522 | 基因类型: protein coding

关于 SCAMP1

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:78,360,617-78,480,739 (from NCBI)

This gene has 7 transcripts (splice variants), 259 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 21.2), thyroid (RPKM 14.8) and 25 other tissues.

功能概要

该基因产物属于 SCAMP 蛋白家族,属于分泌性载体膜蛋白。它们在后高尔基体循环途径中充当细胞表面的载体。不同的家族成员是不同基因高度相关的产物,通常一起表达。这些发现表明,这些蛋白质家族成员可能在囊泡运输过程中的同一位点发挥作用,而不是在不同的途径中发挥作用。已在 1 号染色体上定义了该基因的假基因。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 3 月]

This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

SCAMP1 基因产物(2)

mRNA Protein Name
NM_001290229.2 NP_001277158.1 secretory carrier-associated membrane protein 1 isoform 3
NM_004866.6 NP_004857.4 secretory carrier-associated membrane protein 1 isoform 1

SCAMP1 蛋白结构

SCAMP

SCAMP: SCAMP family (116 - 293)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
蛋白主名 其他名称

secretory carrier-associated membrane protein 1

SCAMP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SCAMP1 O15126 TTPA Homo sapiens P49638
Validated Y2H
32296183
Intra SCAMP1 O15126 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra SCAMP1 O15126 PCYT1A Homo sapiens P49585
Validated Y2H
32296183
Intra SCAMP1 O15126 ARFIP1 Homo sapiens P53367
Validated Y2H
32296183
Intra SCAMP1 O15126 DNAJC13 Homo sapiens O75165
Anti Tag CoIP
33961781
Intra SCAMP1 O15126 DNAJC13 Homo sapiens O75165
Anti Tag CoIP
28514442
Intra SCAMP1 O15126 ARFIP2 Homo sapiens P53365
Validated Y2H
32296183
Intra SCAMP1 O15126 TBRG4 Homo sapiens Q969Z0
Validated Y2H
32296183
Intra SCAMP1 O15126 THAP4 Homo sapiens Q8WY91
Validated Y2H
32296183
Intra SCAMP1 O15126 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra SCAMP1 O15126 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra SCAMP1 O15126 PTPN9 Homo sapiens P43378
Validated Y2H
32296183
Intra SCAMP1 O15126 MTERF3 Homo sapiens Q96E29
Validated Y2H
32296183
Intra SCAMP1 O15126 GAD2 Homo sapiens Q05329
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood Kidney Cell Carcinoma

Pediatric Renal Cell Carcinoma

Childhood Renal Cell Carcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SCAMP1 MGD MGI:1349480
Macaca mulatta SCAMP1 VGNC VGNC:84489
Bos taurus SCAMP1 VGNC VGNC:34315
Canis familiaris SCAMP1 VGNC VGNC:45890
Felis catus SCAMP1 VGNC VGNC:64895
Rattus norvegicus SCAMP1 RGD RGD:3625