1. Gene
  2. MMD - monocyte to macrophage differentiation associated Gene

MMD - monocyte to macrophage differentiation associated Gene

中文名称:单核细胞向巨噬细胞分化相关

种属: Homo sapiens

同用名: MMA; MMD1; PAQR11

基因 ID: 23531 | 基因类型: protein coding

关于 MMD

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:55,392,622-55,421,835 (from NCBI)

This gene has 4 transcripts (splice variants), 217 orthologues and 10 paralogues. Biased expression in fat (RPKM 97.6), brain (RPKM 27.2) and 9 other tissues.

功能概要

这种蛋白质由体外分化的巨噬细胞表达,但不由新鲜分离的单核细胞表达。虽然序列分析确定了七个潜在的跨膜结构域,但该蛋白与 G 蛋白受体几乎没有同源性,并且尚未被肯定地鉴定为受体。建议的替代功能是成熟巨噬细胞中离子通道蛋白的功能。[RefSeq 提供,2008 年 7 月]

This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]

MMD 基因产物(1)

mRNA Protein Name
NM_012329.3 NP_036461.2 monocyte to macrophage differentiation factor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
21968647 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
21968647 GOA
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
21968647 GOA
involved in regulation of protein localization IDA
IDA: 通过直接分析推断
21968647 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
21968647 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MMD 蛋白结构

HlyIII

HlyIII: Haemolysin-III related (24 - 220)

  • 0
  • 100
  • 200
  • 238 a.a.
蛋白主名 其他名称

monocyte to macrophage differentiation factor

macrophage maturation-associated

MMD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MMD Q15546 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra MMD Q15546 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra MMD Q15546 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra MMD Q15546 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra MMD Q15546 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra MMD Q15546 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra MMD Q15546 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra MMD Q15546 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra MMD Q15546 TMEM42 Homo sapiens Q69YG0
Validated Y2H
32296183
Intra MMD Q15546 ATP13A1 Homo sapiens Q9HD20-3
Validated Y2H
32296183
Intra MMD Q15546 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra MMD Q15546 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra MMD Q15546 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra MMD Q15546 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra MMD Q15546 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra MMD Q15546 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra MMD Q15546 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra MMD Q15546 OCIAD1 Homo sapiens Q9NX40
Validated Y2H
32296183
Intra MMD Q15546 EMC6 Homo sapiens Q9BV81
Validated Y2H
32296183
Intra MMD Q15546 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra MMD Q15546 SFXN1 Homo sapiens Q9H9B4
Validated Y2H
32296183
Intra MMD Q15546 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra MMD Q15546 PLEKHO1 Homo sapiens Q53GL0
Validated Y2H
32296183
Intra MMD Q15546 PLEKHO1 Homo sapiens Q53GL0
Y2H Array
32296183
Intra MMD Q15546 PLEKHO1 Homo sapiens Q53GL0
Y2H Prey Pooling
32296183
Intra MMD Q15546 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

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直系同源

种属 基因名 来源 基因 ID
Bos taurus MMD VGNC VGNC:31512
Canis familiaris MMD VGNC VGNC:43270
Felis catus MMD VGNC VGNC:68277
Macaca mulatta MMD VGNC VGNC:74885
Mus musculus MMD MGD MGI:1914718
Rattus norvegicus MMD RGD RGD:1592079
Others MMD NCBI