2. Gene
  3. SLC16A7 - solute carrier family 16 member 7 Gene

SLC16A7 - solute carrier family 16 member 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 16 成员 7

种属: Homo sapiens

同用名: MCT2

基因 ID: 9194 | 基因类型: protein coding

关于 SLC16A7

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:59,596,029-59,789,841 (from NCBI)

This gene has 16 transcripts (splice variants), 254 orthologues and 13 paralogues. Broad expression in fat (RPKM 11.7), heart (RPKM 9.2) and 22 other tissues.

功能概要

该基因是单羧酸转运蛋白家族的成员。该家族的成员运输代谢物，例如乳酸、丙酮酸和酮体。该基因编码的蛋白质催化单羧酸盐的质子连接转运，对丙酮酸具有最高的亲和力。据报道，与对照标本相比，这种蛋白质在前列腺癌和结直肠癌标本中的表达更高。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 7 月]

This gene is a member of the Monocarboxylate Transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal Cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

SLC16A7 基因产物(14)

mRNA Protein Name
XM_017020226.3 XP_016875715.1 monocarboxylate transporter 2 isoform X3
XM_047429885.1 XP_047285841.1 monocarboxylate transporter 2 isoform X3
XM_024449276.2 XP_024305044.1 monocarboxylate transporter 2 isoform X2
NR_073056.2
XM_011538989.3 XP_011537291.1 monocarboxylate transporter 2 isoform X1
XM_011538992.3 XP_011537294.1 monocarboxylate transporter 2 isoform X1
NM_001270622.2 NP_001257551.1 monocarboxylate transporter 2
XM_011538990.4 XP_011537292.1 monocarboxylate transporter 2 isoform X1
NM_001270623.2 NP_001257552.1 monocarboxylate transporter 2
NR_073055.2
XM_011538991.3 XP_011537293.1 monocarboxylate transporter 2 isoform X1
NM_004731.5 NP_004722.2 monocarboxylate transporter 2
XM_011538995.3 XP_011537297.1 monocarboxylate transporter 2 isoform X3
XM_005269231.4 XP_005269288.1 monocarboxylate transporter 2 isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
32415067 GOA
enables lactate transmembrane transporter activity IDA
IDA: 通过直接分析推断
9786900 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables pyruvate transmembrane transporter activity IDA
IDA: 通过直接分析推断
9786900 GOA
enables symporter activity IDA
IDA: 通过直接分析推断
32415067 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lactate transmembrane transport IMP
IMP: 通过突变表型推断
9786900 GOA
involved in pyruvate transmembrane transport IDA
IDA: 通过直接分析推断
9786900 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
15505343 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC16A7 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (27 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
蛋白主名 其他名称

monocarboxylate transporter 2

solute carrier family 16 (monocarboxylate transporter), member 7

solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

关联疾病

疾病名称 别名
Pharynx Squamous Cell Carcinoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13029 SLC16A7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13030 Slc16a7 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13031 Slc16a7 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SLC16A7 VGNC VGNC:46245
Felis catus SLC16A7 VGNC VGNC:65214
Bos taurus SLC16A7 VGNC VGNC:34693
Mus musculus SLC16A7 MGD MGI:1330284
Macaca mulatta SLC16A7 VGNC VGNC:77400
Rattus norvegicus SLC16A7 RGD RGD:3691
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