ACSL5 - acyl-CoA synthetase long chain family member 5 Gene

中文名称：酰基辅酶 A 合成酶长链家族成员 5

种属: Homo sapiens

同用名: ACS2; ACS5; FACL5

关于 ACSL5

功能概要

该基因编码的蛋白质是长链脂肪酸辅酶 A 连接酶家族的一种同工酶。尽管底物特异性、亚细胞定位和组织分布不同，但该家族的所有同工酶都将游离的长链脂肪酸转化为脂肪酰基辅酶 A 酯，从而在脂质生物合成和脂肪酸降解中发挥关键作用。这种同功酶在子宫和脾脏中高度表达，在正常大脑中有微量表达，但在恶性神经胶质瘤中水平显着升高。该基因在介导脂肪酸诱导的神经胶质瘤细胞生长中发挥作用。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A Ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]