2. Gene
  3. AGPAT3 - 1-acylglycerol-3-phosphate O-acyltransferase 3 Gene

AGPAT3 - 1-acylglycerol-3-phosphate O-acyltransferase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：1-酰基甘油-3-磷酸 O-酰基转移酶 3

种属: Homo sapiens

同用名: LPAAT3; LPLAT3; 1-AGPAT 3; LPAAT-GAMMA1

基因 ID: 56894 | 基因类型: protein coding

关于 AGPAT3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:43,865,223-43,987,592 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 12.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种酰基转移酶，可将溶血磷脂酸转化为磷脂酸，这是从头磷脂生物合成途径的第二步。编码的蛋白质可以是整合膜蛋白。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is an Acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

AGPAT3 基因产物(5)

mRNA Protein Name
NM_001037553.2 NP_001032642.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369878.1 NP_001356807.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369880.1 NP_001356809.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369881.1 NP_001356810.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 2
NM_020132.5 NP_064517.1 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: 通过直接分析推断
21173190 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
21173190 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
21173190 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGPAT3 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (83 - 230)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
蛋白主名 其他名称

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1-AGP acyltransferase 3

AGPAT3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra AGPAT3 Q9NRZ7 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra AGPAT3 Q9NRZ7 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra AGPAT3 Q9NRZ7 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra AGPAT3 Q9NRZ7 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra AGPAT3 Q9NRZ7 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Complete Generalized Lipodystrophy
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00458 AGPAT3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AGPAT3 RGD RGD:1305787
Canis familiaris AGPAT3 VGNC VGNC:37712
Felis catus AGPAT3 VGNC VGNC:59686
Macaca mulatta AGPAT3 VGNC VGNC:84744
Mus musculus AGPAT3 MGD MGI:1336186
Bos taurus AGPAT3 VGNC VGNC:25736
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