2. Apoptosis
  3. Bcl-2 Family
  4. Mcl1-IN-12

Mcl1-IN-12 (Compound F) 是一种选择性的 Mcl-1 抑制剂，对 Bcl-2 的作用较弱，Ki 值分别为 0.29 和 3.1 μM。

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Mcl1-IN-12 Chemical Structure

Mcl1-IN-12 Chemical Structure

CAS No. : 2042211-12-9

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Mcl1-IN-12 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively. Anti-tumor activity[1].

IC50 & Target

Ki: 0.29 (Mcl-1), 3.1 μM (Bcl-2)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
2.92 μM
Compound: F
Growth inhibition of human HL60 cells after 72 hrs by MTT assay
Growth inhibition of human HL60 cells after 72 hrs by MTT assay
[PMID: 27712939]
MCF7 IC50
0.26 μM
Compound: F
Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
[PMID: 27712939]
NCI-H23 IC50
8.38 μM
Compound: F
Growth inhibition of human NCI-H23 cells after 72 hrs by MTT assay
Growth inhibition of human NCI-H23 cells after 72 hrs by MTT assay
[PMID: 27712939]
SK-OV-3 IC50
7.83 μM
Compound: F
Growth inhibition of human SKOV3 cells after 72 hrs by MTT assay
Growth inhibition of human SKOV3 cells after 72 hrs by MTT assay
[PMID: 27712939]
U-266 IC50
6.95 μM
Compound: F
Growth inhibition of human U266 cells after 72 hrs by MTT assay
Growth inhibition of human U266 cells after 72 hrs by MTT assay
[PMID: 27712939]
分子量

803.00

Formula

C45H46N4O6S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mcl1-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mcl1-IN-122042211-12-9Bcl-2 FamilyInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-100763
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