2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2-IN-11

Bcl-2-IN-11 (compound 6) 是一种有效的选择性 Bcl-2 活性抑制剂，IC50 为 0.9 nM 。 Bcl-2-IN-11 对 Bcl-xl 是微弱的抑制作用 (IC50 > 1000 nM)。 Bcl-2-IN-11 可用于 Bcl-2 家族蛋白异常过量表达导致的多种癌症的研究：特别是急性淋巴性白血病的恶性血液病等。Bcl-2-IN-11 还可避免由 Bcl-xl 抑制引起的毒副作用，如血小板降低。

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Bcl-2-IN-11 Chemical Structure

Bcl-2-IN-11 Chemical Structure

CAS No. : 2760536-88-5

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Bcl-2-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].

IC50 & Target

Bcl-2

0.9 nM (IC50)

Bcl-xL

>1000 nM (IC50)

体外研究
(In Vitro)

Bcl-2-IN-11 (compound 6) 可抑制 RS4;11 急性淋巴细胞增殖，IC50 为 2.37 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bcl-2-IN-11 相关抗体:
分子量

902.43

Formula

C45H49ClFN7O8S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bcl-2-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-112760536-88-5Bcl-2 FamilyRS4;11acute lymphoid leukemiaInhibitorinhibitorinhibit

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