2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. Bcl-2-IN-10

Bcl-2-IN-10 是一种有活性的 Bcl-2 抑制剂，可释放多达四个一氧化氮 (NO) 分子。Bcl-2-IN-10 对人类白血病、乳腺癌和肺癌等癌细胞具有细胞毒性。Bcl-2-IN-10 可诱导细胞凋亡 (apopotosis)，阻滞细胞周期在 G2/M 期，可用于癌症相关的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Bcl-2-IN-10 Chemical Structure

Bcl-2-IN-10 Chemical Structure

CAS No. : 2773354-28-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Bcl-2-IN-10 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research[1].

IC50 & Target[1]

Bax

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
11.3 μM
Compound: 1
Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
BT-474 IC50
7.06 μM
Compound: 1
Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
CCRF-CEM IC50
1.26 μM
Compound: 1
Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
Jurkat E6.1 IC50
1.94 μM
Compound: 1
Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
MDA-MB-231 IC50
17.86 μM
Compound: 1
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
体外研究
(In Vitro)

Steroid sulfatase-IN-2 (compound 1, 0-20 μM approximately, 72 h) inhibits different cancer cells with IC50s ranging from 1.26 μM to 17.86 μM[1].
Steroid sulfatase-IN-2 (1 μM, 5 h) releases up to four molecules of nitric oxide[1].
Steroid sulfatase-IN-2 (8 μM, 8-72 h) induces leukemia cell CCRF-CEM apoptosis via MAPKs pathways, arrests cell in the G2/M phase, and increases ratio of Bax/Bcl-2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bcl-2-IN-10 相关抗体:

Apoptosis Analysis[1]

Cell Line: CEM cells
Concentration: 8 μM
Incubation Time: 8, 24, 48 or 72 h
Result: Induced apoptosis in a time-dependent and dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: CEM cells
Concentration: 8 μM
Incubation Time: 8, 24, 48 or 72 h
Result: Arrested cell in the G2/M phase.

Western Blot Analysis[1]

Cell Line: CEM cells
Concentration: 0-8 μM
Incubation Time: 72 h
Result: Increased the levels of JNK and p38, and the levels of phosphorylated JNK and p38.
Decreased Bcl-2 level in a time- and dose-dependent manner, and increased pro-apoptotic Bax level.
分子量

635.50

Formula

C22H25N11O12
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bcl-2-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-102773354-28-0Bcl-2 FamilyApoptosisDDNO derivativesanti-cancerNOapopotosisBax/Bcl-2MAPKInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Bcl-2-IN-10
目录号：
HY-150540
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z