2. Gene
  3. PPL - periplakin Gene

PPL - periplakin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：周膜蛋白

种属: Homo sapiens

基因 ID: 5493 | 基因类型: protein coding

关于 PPL

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,882,507-4,937,148 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 300.0) and skin (RPKM 63.7).

功能概要

由该基因编码的蛋白质是桥粒和角质形成细胞表皮角质化包膜的组成部分。该蛋白的 N 端结构域与质膜相互作用，其 C 端与中间丝相互作用。通过其杆域，该蛋白质与 envoplakin 形成复合物。这种蛋白质可以作为角化包膜和桥粒以及中间丝之间的联系。据报道，Akt1/PKB 是一种介导多种细胞生长和存活信号转导过程的蛋白激酶，可与该蛋白相互作用，表明该蛋白可能作为 Akt1 介导的信号转导中的定位信号发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. Akt1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

PPL 基因产物(1)

mRNA Protein Name
NM_002705.5 NP_002696.4 periplakin
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12244133 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
19211270 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPL 蛋白结构

Plectin

Plectin: Plectin repeat (1660 - 1692)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1756 a.a.
蛋白主名 其他名称

periplakin

190 kDa paraneoplastic pemphigus antigen

PPL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PPL O60437 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra PPL O60437 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra PPL O60437 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra PPL O60437 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra PPL O60437 DES Homo sapiens P17661
Validated Y2H
32296183
Intra PPL O60437 DES Homo sapiens P17661
Y2H Array
32296183
Intra PPL O60437 DES Homo sapiens P17661
Y2H Prey Pooling
32296183
Intra PPL O60437 C6orf141 Homo sapiens Q5SZD1
Y2H Array
32296183
Intra PPL O60437 C6orf141 Homo sapiens Q5SZD1
Y2H Prey Pooling
32296183
Intra PPL O60437 C6orf141 Homo sapiens Q5SZD1
Validated Y2H
32296183
Intra PPL O60437 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra PPL O60437 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra PPL O60437 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra PPL O60437 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra PPL O60437 KRT39 Homo sapiens Q6A163
Validated Y2H
32296183
Intra PPL O60437 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra PPL O60437 KCTD21 Homo sapiens Q4G0X4
Validated Y2H
32296183
Intra PPL O60437 KCTD21 Homo sapiens Q4G0X4
Y2H Prey Pooling
32296183
Intra PPL O60437 KCTD21 Homo sapiens Q4G0X4
Y2H Array
32296183
Intra PPL O60437 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra PPL O60437 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra PPL O60437 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra PPL O60437 RAB3IP Homo sapiens Q96QF0-7
Validated Y2H
32296183
Intra PPL O60437 RAB3IP Homo sapiens Q96QF0-7
Y2H Prey Pooling
32296183
Intra PPL O60437 RAB3IP Homo sapiens Q96QF0-7
Y2H Array
32296183
Intra PPL O60437 POF1B Homo sapiens Q8WVV4-1
Y2H Prey Pooling
32296183
Intra PPL O60437 POF1B Homo sapiens Q8WVV4-1
Validated Y2H
32296183
Intra PPL O60437 POF1B Homo sapiens Q8WVV4-1
Y2H Array
32296183
Intra PPL O60437 ZSCAN1 Homo sapiens Q8NBB4-2
Validated Y2H
32296183
Intra PPL O60437 ZSCAN1 Homo sapiens Q8NBB4-2
Y2H Prey Pooling
32296183
Intra PPL O60437 ZSCAN1 Homo sapiens Q8NBB4-2
Y2H Array
32296183
Intra PPL O60437 PLEKHA7 Homo sapiens Q6IQ23-2
Y2H Prey Pooling
32296183
Intra PPL O60437 PLEKHA7 Homo sapiens Q6IQ23-2
Validated Y2H
32296183
Intra PPL O60437 PLEKHA7 Homo sapiens Q6IQ23-2
Y2H Array
32296183
Intra PPL O60437 ZNF213 Homo sapiens O14771
Y2H Array
32296183
Intra PPL O60437 ZNF213 Homo sapiens O14771
Y2H Prey Pooling
32296183
Intra PPL O60437 ZNF474 Homo sapiens Q6S9Z5
Y2H Array
32296183
Intra PPL O60437 ZNF474 Homo sapiens Q6S9Z5
Y2H Prey Pooling
32296183
Intra PPL O60437 ZNF474 Homo sapiens Q6S9Z5
Validated Y2H
32296183
Intra PPL O60437 AHCYL1 Homo sapiens O43865
Y2H Prey Pooling
25416956
Intra PPL O60437 HECTD3 Homo sapiens Q5T447
Y2H Prey Pooling
32296183
Intra PPL O60437 HECTD3 Homo sapiens Q5T447
Y2H Array
32296183
Intra PPL O60437 HECTD3 Homo sapiens Q5T447
Validated Y2H
32296183
Intra PPL O60437 AKT1 Homo sapiens P31749
Y2H
18624398
Intra PPL O60437 VIM Homo sapiens P08670
Validated Y2H
25416956
Intra PPL O60437 VIM Homo sapiens P08670
Y2H Array
25416956
Intra PPL O60437 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra PPL O60437 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra PPL O60437 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra PPL O60437 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra PPL O60437 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra PPL O60437 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra PPL O60437 KNSTRN Homo sapiens Q9Y448
Y2H Array
32296183
Intra PPL O60437 KNSTRN Homo sapiens Q9Y448
Validated Y2H
32296183
Intra PPL O60437 KNSTRN Homo sapiens Q9Y448
Y2H Prey Pooling
32296183
Intra PPL O60437 ALAS1 Homo sapiens P13196
Y2H Array
32296183
Intra PPL O60437 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
25416956
Intra PPL O60437 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
32296183
Intra PPL O60437 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
Intra PPL O60437 ALAS1 Homo sapiens P13196
Validated Y2H
32296183
Intra PPL O60437 ALAS1 Homo sapiens P13196
Y2H Array
25416956
Intra PPL O60437 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
Intra PPL O60437 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
Intra PPL O60437 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
Intra PPL O60437 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra PPL O60437 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra PPL O60437 HTT Homo sapiens P42858
Y2H Array
32814053
Intra PPL O60437 HTT Homo sapiens P42858
Y2H
17500595
Intra PPL O60437 ZSCAN1 Homo sapiens Q8NBB4
Validated Y2H
25416956
Intra PPL O60437 ZSCAN1 Homo sapiens Q8NBB4
Y2H Prey Pooling
25416956
Intra PPL O60437 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra PPL O60437 ANXA9 Homo sapiens O76027
IF
22841549
Intra PPL O60437 ANXA9 Homo sapiens O76027
Anti Tag CoIP
22841549
Intra PPL O60437 MRPL28 Homo sapiens Q13084
Y2H Prey Pooling
32296183
Intra PPL O60437 MRPL28 Homo sapiens Q13084
Validated Y2H
32296183
Intra PPL O60437 MRPL28 Homo sapiens Q13084
Y2H Array
32296183
Intra PPL O60437 ZSCAN16 Homo sapiens Q9H4T2
Validated Y2H
32296183
Intra PPL O60437 ZSCAN16 Homo sapiens Q9H4T2
Y2H Prey Pooling
32296183
Intra PPL O60437 ZSCAN16 Homo sapiens Q9H4T2
Y2H Array
32296183
Intra PPL O60437 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
25416956
Intra PPL O60437 ZNF165 Homo sapiens P49910
Y2H Prey Pooling
32296183
Intra PPL O60437 ZNF165 Homo sapiens P49910
Validated Y2H
32296183
Intra PPL O60437 ZNF165 Homo sapiens P49910
Y2H Array
32296183
Intra PPL O60437 UPRT Homo sapiens Q96BW1
Y2H Prey Pooling
32296183
Intra PPL O60437 UPRT Homo sapiens Q96BW1
Y2H Array
32296183
Intra PPL O60437 UPRT Homo sapiens Q96BW1
Validated Y2H
32296183
Intra PPL O60437 ZNF263 Homo sapiens O14978
Y2H Array
32296183
Intra PPL O60437 ZNF263 Homo sapiens O14978
Y2H Prey Pooling
32296183
Intra PPL O60437 RAB3IP Homo sapiens Q96QF0
Validated Y2H
25416956
Intra PPL O60437 RAB3IP Homo sapiens Q96QF0
Y2H Array
25416956
Intra PPL O60437 RALBP1 Homo sapiens Q15311
Y2H Prey Pooling
25416956
Intra PPL O60437 ACTR5 Homo sapiens Q9H9F9
Validated Y2H
32296183
Intra PPL O60437 ACTR5 Homo sapiens Q9H9F9
Y2H Array
32296183
Intra PPL O60437 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra PPL O60437 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra PPL O60437 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Paraneoplastic Pemphigus
Pemphigus
Pemphigus Foliaceus

Pemphigus Foliaceous

Pf

Superficial Pemphigus
Pemphigus Vulgaris, Familial

Pemphigus Vulgaris

Familial Pemphigus Vulgaris

Pemphigus
Bullous Pemphigoid

Benign Pemphigus

Senile Dermatitis Herpetiformis

Old Age Pemphigus

Parapemphigus

Pemphigoid

Pemphigoid Bullous

Pemphigoid, Bullous
Pemphigoid
Bronchiolitis Obliterans

Bronchiolitis Fibrosa Obliterans

Obliterative Bronchiolitis

Bronchiolitis Exudativa

Bronchiolitis, Exudative
Thymoma

Primary Thymic Epithelial Neoplasm

Primary Thymic Epithelial Tumor

Thymus Neoplasms
Pseudomembranous Conjunctivitis
Iga Pemphigus
Subcorneal Pustular Dermatosis

Subcorneal Pustular Dermatitis

Sneddon-Wilkinson Disease Or Syndrome

Pustulosis Subcornealis

Sneddon-Wilkinson Disease

Skin Diseases, Vesiculobullous

Vesiculobullous Skin Disease
Bullous Skin Disease

Skin Diseases Bullous

Skin Diseases, Bullous
Pemphigoid Gestationis

Herpes Gestationis

Gestational Pemphigoid

Gestational Herpes
Microcephaly And Chorioretinopathy 2
Acute Conjunctivitis
Lichen Disease
Castleman Disease

Angiofollicular Ganglionic Hyperplasia

Angiofollicular Lymph Hyperplasia

Giant Lymph Node Hyperplasia

Castleman'S Disease

Angiofollicular Lymph Node Hyperplasia

Lymphoid Hamartoma

Benign Giant Lymphoma

Angiolymphoid Hyperplasia
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107098 PPL-100 free acid / 否
HY-E70307 Lipase, Porcine Pancreas / 否
HY-RS10959 PPL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPL MGD MGI:1194898
Canis familiaris PPL VGNC VGNC:44861
Rattus norvegicus PPL RGD RGD:1305511
Felis catus PPL VGNC VGNC:68991
Bos taurus PPL VGNC VGNC:33208
Macaca mulatta PPL VGNC VGNC:76240
Others PPL NCBI
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